Immunomodulatory Activity of Aqueous Leaf Extract of Ocimum sanctum

Venkatachalam, V. V.; Rajinikanth, B.

doi:10.1007/978-81-322-1035-1_37

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Immunomodulatory effect of aqueous extract of O. sanctum in rat was investigated by its administration orally at 100 and 200 mg/kg/day for 45 days. Increasing antibody production in dose-dependent manner was observed along with increased RBC, WBC and haemoglobin production, thus, proving immunomodulatory and haematological activity of the herb 24 . Amelioration of endosulfan induced immunotoxicity by O. sanctum was studied in male wistar rats by mixing in ground nut oil in the concentrations of 6, 3 and 1.5 mg/kg body weight.…”

Section: Immunomodulatory Potentialmentioning

confidence: 75%

An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

Khair-ul-Bariyah¹

2013

Pak. J. Chem

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Ocimum sanctum, known as Queen of Herbs, is an important member of the family Lamiaceae due to its use in herbal medication centuries back, especially, in India and other parts of the sub-continent. It is still a subject of immense importance in modern medical research and it is due to the chemical constituents present in it like flavonoids, terpenoids, alkaloids, saponins, vitamins, minerals, proteins, carbohydrates and many others. It has shown a wide range of therapeutic potencies like antimicrobial, anticataleptic, antitoxic, immunomodulatory, analgesic, antidiabetic and cardioprotective activities. The aim of the present review is to present an extensive survey on the phytochemistry and pharmacological applications of the herb.

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Section: Immunomodulatory Potentialmentioning

confidence: 75%

An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

Khair-ul-Bariyah¹

2013

Pak. J. Chem

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“…The herbs Giloy, Tulsi and Kalmegh are renowned for their various health benefits in Ayurveda. [ 18 19 20 ] These herbs have exhibited antiviral,[ 26 27 28 ] anti-inflammatory,[ 29 30 31 ] immunomodulatory,[ 32 33 34 ] antiallergic,[ 35 36 37 ] antipyretic,[ 38 39 40 ] and antioxidant[ 41 42 43 ] potential in scientific studies. Chyawanprash is a traditionally renowned ayurvedic health supplement that has been studied extensively in scientific and clinical studies for its immunostimulatory,[ 44 45 ] antioxidant and anti-inflammatory potentials.…”

Section: Discussionmentioning

confidence: 99%

Prospective, Randomized, Open-Label, Blinded End Point, Two-Arm, Comparative Clinical Study to Evaluate the Efficacy and Safety of a Fixed Ayurvedic Regimen (FAR) as Add-on to Conventional Treatment in the Management of Mild and Moderate COVID-19 Patients

Gupta

Vedula

Srivastava

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Background: The traditional healthcare systems are being avidly looked into in the quest for effective remedies to tackle the menace of COVID-19 pandemic. Objective: This was a prospective randomized, controlled open-label, blinded end point (PROBE) study to evaluate the efficacy and safety of a fixed ayurvedic regimen (FAR) as an add-on to conventional treatment/standard of care (SOC) in the management of mild-to-moderate COVID-19 infection. Methodology: A total of 68 patients were recruited who consumed either FAR + SOC (n = 35) or SOC only (n = 33) for 28 days. Primary outcomes assessed were mean time required for clinical recovery and proportion of patients showing clinical recovery between the groups. Secondary outcomes assessed included mean time required for testing SARS-CoV-2 negative, change in clinical status on World Health Organization (WHO) ordinal scale, number of days of hospitalization, change in disease progression and requirement of oxygen/intensive care unit admission/ventilator support/rescue medication, health status on WHO quality of life (QOL) BREF and safety on the basis of occurrence of adverse event/serious adverse event (AE/SAE) and changes in laboratory parameters. Results: Patients consuming FAR as an add-on SOC showed faster clinical recovery from the day of onset of symptoms by 51.34% (P < 0.05) as compared to SOC group. A higher proportion of patients taking FAR recovered within the first 2 weeks compared to those taking only SOC. It was observed that 5 times more patients recovered within 7 days in FAR group when compared to SOC (P < 0.05) group. An earlier clinical recovery was observed in clinical symptoms such as sore throat, cough, loss of taste and myalgia (P < 0.05). Improvement in postclinical symptoms such as appetite, digestion, stress and anxiety was also obs served to be better with the use of FAR. Requirement of rescue medications such as antipyretics, analgesics and antibiotics was also found to be reduced in the FAR group (P < 0.05). FAR showed a significant improvement in all the assessed domains of QOL. None of the AEs/SAE reported in the study were assessed to be related to the study drugs. Further, FAR did not produce any significant change in the laboratory safety parameters and was assessed to be safe. Conclusion: FAR could be an effective and safe add-on ayurvedic regimen to standard of care in the management of mild and moderate COVID-19 patients. CTRI number: CTRI/2020/09/027914.

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Immunomodulatory Activity of Aqueous Leaf Extract of Ocimum sanctum

Cited by 2 publications

References 5 publications

An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

Prospective, Randomized, Open-Label, Blinded End Point, Two-Arm, Comparative Clinical Study to Evaluate the Efficacy and Safety of a Fixed Ayurvedic Regimen (FAR) as Add-on to Conventional Treatment in the Management of Mild and Moderate COVID-19 Patients

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