An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

Khair-ul-Bariyah, Syeda

doi:10.15228/2013.v03.i01.p02

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…A similar survey has been carried out in South Sumatra, Indonesia. The other survey has been also conducted in other country in Asia such as in Pakistan [13], and Iran [14].…”

Section: Introductionmentioning

confidence: 99%

Some of South Sumatran Plants Containing Alkaloids

Eliza¹,

Basir²

2022

IJFAC

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A phytochemical survey for alkaloid-containing plants has been conducted in South Sumatra including traditional medicinal plants. During the survey 180 satisfactory herbarium sample were obtained and all of them were tested for alkaloids. The results showed that 33 species gave a positive test for alkaloids, and high alkaloid contents were shown by: Alstonia scholaris, Alstonia angustiloba, Ervatamia coronariaa, Voacanga foetida Bl. K. Schum, Litseaacceden toides K & V, Litsea angualata, Litsea tomentosa, Fibraurea chloroleuca Miers (root), and Uncaria cordata (Lour.) Merr. The aboved survey was also continued to be an intensively phytochemical work focusing on alkaloid of Fibraurea chloroleuca Miers root. A quaternary isoquinoline alkaloid as a yellowish crystal, m.p. 214-215 oC; MS (FAB) m/z 352 has been successfully isolated and tested for antibacterial activity. This isolated alkaloid significantly inhibited Bacilus substilis, Shigela dysentriae, Staphylococus aireus, and Pseudomonas sp growth at 1 mg/mL. As a result, all of these alkaloid-containing plants are potential to explore their alkaloids and utilitarian for traditional medicines.

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“…A similar survey has been carried out in South Sumatra, Indonesia. The other survey has been also conducted in other country in Asia such as in Pakistan [13], and Iran [14].…”

Section: Introductionmentioning

confidence: 99%

Some of South Sumatran Plants Containing Alkaloids

Eliza¹,

Basir²

2022

IJFAC

View full text Add to dashboard Cite

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Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles

Ramdas¹,

Botha²,

Krishna³

et al. 2017

Saudi Journal of Biological Sciences

136

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The role of silver nanoparticles (AgNps) is an attractive proposition for advancing modern diabetes therapies and applied science. Stable AgNps with a size range of 3-25 nm were synthesized using aqueous leaf extracts from ,, and in combination. The concentration of the extracts facilitated the reduction of silver nitrate that led to the rapid formation of AgNps at room temperature, indicating a higher reaction rate as opposed to harsh chemical methods, and high conversion energy usually involved in the synthesis. The size, shape and elemental analysis were carried out using UV-Visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), dynamic light scattering (DLS), and zeta potential whilst, Fourier transform infrared (FTIR) supported by gas chromatography mass spectroscopy (GC-MS) was used to identify the type of capping agents. Inhibition of α-amylase and α-glucosidase enzymes retards the rate of carbohydrate digestion, thereby provides an alternative and a less evasive strategy of reducing postprandial hyperglycaemia in diabetic patients. The AgNps derived from and, respectively displayed an inhibitory effect at 89.31 ± 5.32%, and 79.74 ± 9.51%, respectively, against α-glucosidase enzyme model, indicating an enhanced biocatalytic potential compared to their respective crude extracts and the control. Furthermore, the emerging rate of infections in diabetic patients validates the need for the discovery of dual diabetes therapies. As a result, the bioderived AgNps displayed antimicrobial activity against bacterial species, ,, , and species.

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Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review

Rawat

Jhawat

Dutt³

2023

CDT

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Diabetes mellitus is a long-lasting disease that is very common in the age group above 20 years and is characterized by hyperglycemia with other complications like Diabetic Nephropathy (DN). The management of DN focuses on mainly four regions: reduction of cardiovascular risks, control of blood glycemic levels, control of the blood pressure (BP) profile, and the use of therenin–angiotensin system (RAS). Although BP management and RAS-acting agents can postpone the onset of DN, they cannot prevent it. In the modern era, nanotechnological interventions have spread rapidly in the field of medicine. Patient defiance is considered important in diabetes management when long-term or continuous management is required. Nano pharmaceuticals have been shown to increase compliance of diabetic patients by providing multiple ways of drug delivery, controlling release profile, increasing biological steadiness, targeting efficacy, and decreasing toxic profile. Nanoscale formulations of botanical antidiabetic molecules improve clinical efficacy and treatment compliance by overcoming associated biopharmaceutical and pharmacokinetic barriers. Therefore, the development of nanopharmaceuticals can be considered to be a possible answer to attain the finest scientific effect of the plant-based anti-diabetic molecule. Nevertheless, further studies are needed to create clinical research-based and therapeutically effective nanoforms of antidiabetic plant-based molecules to combat the most dreaded disease of diabetes and its known present complications.

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An Extensive Survey of the Phytochemistry and Therapeutic Potency of Ocimum sanctum (Queen of Herbs)

Cited by 4 publications

References 24 publications

Some of South Sumatran Plants Containing Alkaloids

Some of South Sumatran Plants Containing Alkaloids

Enhancing antidiabetic and antimicrobial performance of Ocimum basilicum, and Ocimum sanctum (L.) using silver nanoparticles

Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review

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