The role of herbal preparations in ameliorating neurodegenerative disorders has been increasing due to their significant contribution towards health, wellness and therapy. The aim of the present study was to evaluate effect of ethanolic extract of Moringa concanensis nimmo (EEMC), ethanolic extract of Sesbania grandiflora (EESG) and their combination (MCSG-CE) prepared using 1:1 ratio of their ethanolic extracts for their neuroprotective effect against 6-Hydroxy dopamine (6-OHDA) induced parkinsonism in rats. Wistar albino rats were allocated into 8 groups (n = 6) and treated as follows: Gp-I: Vehicle control- 1% v/v Tween 80; Gp-II: Positive control- 6-OHDA (8μg/2μl/rat); Gp- III: 6-OHDA+levodopa (6mg/kg, p.o); Gp-IV: 6-OHDA+EEMC-I (100 mg/kg, p.o.); Gp-V: 6-OHDA+EEMC-II (200 mg/kg, p.o.) and Gp-VI: 6-OHDA+ EESG-I (100 mg/kg, p.o.); Group-VII: 6-OHDA+EESG-II (200 mg/kg, p.o.) and Gp-VIII: 6-OHDA+MCSG-CE (100 mg/kg, p.o.). All the animals were exposed to respective treatments for seven days after disease induction and then subjected to catalepsy (forelimb placing) test, Rotarod test and Morris-water maze test. The treated groups exhibited significant activity in reducing the catalepsy severity score, increasing the fall-off time and decrease in the escape latency time. The findings of this study indicated that Moringa concanensis and Sesbania grandiflora exhibit remarkable neuroprotective potential and ameliorate major symptoms of Parkinson’s Disease. Keywords: Parkinson’s Disease, 6-Hydroxy dopamine, Catalepsy, Moringa concanensis, Sesbania grandiflora.
The aim of present investigation includes the collection, authentication of Grewia tiliaefolia Vahl leaves and assess powder microscopical features with the help of standard pharmacognostical procedures listed in Ayurvedic pharmacopoeias to establish identity and quality of the powdered form of leaf drug. Collected leaf samples were washed properly, shade dried and powdered in a mixer grinder. The powdered material was taken on microslide, stained with various colouring reagents and observe under microscope for various cellular arrangements. The leaf powder consists of abundant thick-walled fibres with tapering ends. Thick walled rectangular parenchyma cells are seen in leaf powder, these parenchyma cells have 2-4 cross walls. The lamina showing the venation pattern. The vein-islets are polygonal, narrow, thick straight boundaries. The characteristic epidermal trichomes and epidermal glandular trichomes are common in the powder, these are important diagnostic characters to identify the powder form of the drug. The guard cells in the stomata are narrow elliptical with stomatal aperture.
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