Immunomodulatory Activity of a New Family of Antioxidants Obtained from Grape Polyphenols

Mitjans, Montserrat; Campo, Jaime del; Abajo, Celia; Martı́nez, Verónica; Selga, Ariadna; Lozano, Carles Barriocanal; Torres, Josep Lluı́s; Vinardell, M. Pilar

doi:10.1021/jf049403z

Cited by 24 publications

(19 citation statements)

References 18 publications

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“…These values are lower than epicatechin, a known antioxidant flavonoid that has reported an IC 50 value of 42.3 lg/mL (Mitjans et al, 2004). This indicates a higher antioxidant activity compared to epicatechin.…”

Section: Membrane Erythrocyte Damage Induced By Aaphmentioning

confidence: 76%

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

et al. 2016

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Section: Membrane Erythrocyte Damage Induced By Aaphmentioning

confidence: 76%

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

et al. 2016

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“…muscadine grape extracts in blood mononuclear cells, 56 ellagic acid in activated pancreatic stellate cells, 57 and epicatechin conjugates in whole blood. 58 However, there do not appear to be, at the writing of this paper, studies of IL-1β gene expression in similar paradigms with various fruit extracts. Interestingly, the piroxicam-induced decreases in IL-1β in the PX-KA group were similar to those seen in the BB-KA group.…”

Section: Discussionmentioning

confidence: 89%

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus

Shukitt‐Hale

Lau²,

Carey³

et al. 2008

Nutritional Neuroscience

127

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Cognitive impairment in age-related neurodegenerative diseases such as Alzheimer's disease may be partly due to long-term exposure and increased susceptibility to inflammatory insults. In the current study, we investigated whether polyphenols in blueberries can reduce the deleterious effects of inflammation induced by central administration of kainic acid by altering the expression of genes associated with inflammation. To this end, 4-month-old male Fischer-344 (F344) rats were fed a control, 0.015% piroxicam (an NSAID) or 2% blueberry diet for 8 weeks before either Ringer's buffer or kainic acid was bilaterally micro-infused into the hippocampus. Two weeks later, following behavioral evaluation, the rats were killed and total RNA from the hippocampus was extracted and used in real-time quantitative RT-PCR (qRT-PCR) to analyze the expression of inflammation-related genes. Kainic acid had deleterious effects on cognitive behavior as kainic acid-injected rats on the control diet exhibited increased latencies to find a hidden platform in the Morris water maze compared to Ringer's buffer-injected rats and utilized non-spatial strategies during probe trials. The blueberry diet, and to a lesser degree the piroxicam diet, was able to improve cognitive performance. Immunohistochemical analyses of OX-6 expression revealed that kainic acid produced an inflammatory response by increasing the OX-6 positive areas in the hippocampus of kainic acid-injected rats. Kainic acid up-regulated the expression of the inflammatory cytokines IL-1β and TNF-α, the neurotrophic factor IGF-1, and the transcription factor NF-κB. Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1β, TNF-α, and NF-κB, while only blueberry was able to augment the increased IGF-1 expression. These results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression.

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“…Por outro lado, KALLITHRAKA et al 19 encontraram correlação estatisticamente insignificante avaliando antocianinas totais e capacidade antioxidante em cultivares de Vitis vinifera, neste caso, ressaltando a importância de outros constituintes da uva. Catequinas e epicatequinas, por exemplo, têm demonstrado alta capacidade antioxidante e inibição da proliferação celular 12,26 . Há ainda evidências de que a ingestão de flavonóides como a quercetina e a catequina está associada à redução da oxidação do LDL e à redução da agregação plaquetária, contribuindo para a diminuição da progressão da lesão aterosclerótica 16 .…”

Section: Resultsunclassified

Compostos fenólicos e capacidade antioxidante de cultivares de uvas Vitis labrusca L. e Vitis vinifera L.

Abe¹,

Mota²,

Lajolo³

et al. 2007

Ciênc. Tecnol. Aliment.

142

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ResumoO conteúdo de compostos fenólicos, incluindo resveratrol, antocianinas e outros flavonóides, e a capacidade antioxidante de cinco cultivares de uvas produzidas em Minas Gerais foram determinados. O conteúdo de fenólicos totais, determinado através do método de Folin-Ciocalteau variou significativamente, entre 65 ± 1 e 390 ± 30 mg equivalentes de ácido gálico.100 g -1 de amostra base úmida (b.u.). O conteúdo de antocianinas totais quantificado por CLAE variou entre 6,7 ± 0,2 e 154 ± 4 mg equivalentes de cianidina.100 g -1 (b.u.). Outros flavonóides encontrados foram catequina, epicatequina, quercetina, caempferol além dos ácidos hidroxicinâmicos. O resveratrol foi encontrado em três cultivares, variando entre 0,022 ± 0,001 e 0,60 ± 0,03 mg.100 g -1 (b.u.). A capacidade antioxidante foi analisada usando o método de seqüestro de radicais livres do DPPH (2,2-difenil-1-picrilhidrazila), que variou entre 2,7 ± 0,1 e 19 ± 2 µmoles equivalentes de Trolox.g -1 de amostra (b.u.), mostrando boa correlação com o conteúdo de fenólicos totais. As uvas tintas de coloração mais escura apresentaram maior conteúdo de antocianinas, e conseqüentemente maior teor de fenólicos totais e capacidade antioxidante. Palavras-chave: flavonóides; capacidade antioxidante; Vitis sp. AbstractPhenolic compounds including resveratrol, anthocyanins and other flavonoids and antioxidant capacity were evaluated for five grape cultivars cultivated in Minas Gerais (Brazil). The content of total phenolic determined by the Folin Ciocalteau method varied significantly, from 65 ± 1 to 390 ± 30 mg gallic acid equivalents.100 g -1 of FW (Fresh Weight). The content of total anthocyanins quantified by HPLC varied from 6.7 ± 0.2 to 154 ± 4 mg of cyanidin equivalents.100 g -1 FW. Resveratrol was found in three cultivars, in contents from 0.022 ± 0.001 to 0.60 ± 0.03 mg.100 g -1 of FW. In addition to hydroxicynnamic acids, other flavonoids such as catechin, epicatechin, quercetin and kaempferol were also present. The antioxidant capacity was analyzed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method and varied from 2.7 ± 0.1 to 19 ± 2 µmol trolox equivalents.g -1 FW, showing good correlation with the content of total phenolics. The darker red grapes presented higher anthocyanin contents and consequently higher total phenolic contents and antioxidant capacity. Keywords: flavonoids; antioxidant capacity; Vitis sp.Compostos fenólicos e capacidade antioxidante de cultivares de uvas Vitis labrusca L. e Vitis vinifera L. Phenolic compounds and antioxidant activity of Vitis labrusca and Vitis vinifera cultivarsLucile Tiemi ABE 1 , Renata Vieira DA MOTA 2 , Franco Maria LAJOLO 1 , Maria Inés GENOVESE 1 * IntroduçãoVários efeitos benéficos à saúde têm sido atribuídos aos compostos fenólicos presentes nas frutas, vegetais, chás e vinhos. Estudos epidemiológicos, clínicos e in vitro mostram múl-tiplos efeitos biológicos relacionados aos compostos fenólicos da dieta, tais como: atividades antioxidante, antiinflamatória, antimicrobiana e anticarci...

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Immunomodulatory Activity of a New Family of Antioxidants Obtained from Grape Polyphenols

Cited by 24 publications

References 18 publications

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus

Compostos fenólicos e capacidade antioxidante de cultivares de uvas Vitis labrusca L. e Vitis vinifera L.

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