Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

García-Becerra, Ledy; Mitjans, Montserrat; Rivas-Morales, Catalina; Verde-Star, Julia; Oranday-Cárdenas, Azucena; Vinardell, M. Pilar

doi:10.1016/j.foodchem.2015.08.131

Cited by 19 publications

(14 citation statements)

References 35 publications

(43 reference statements)

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“…In addition, they are more frequently exposed to oxygen than other body tissues and so they are more vulnerable to oxidative damage, causing the oxidation of lipids and proteins in the cell membrane, and thus inducing hemolysis [ 38 ]. Previous studies already have shown that phenolics present in plants offer therapeutic benefits against oxidative damage in erythrocytes [ 7 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

et al. 2018

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This study aimed to compare three different extracts of Saco sweet cherry, namely the non-colored fraction, colored fraction, and total extract concerning phenolic composition, antioxidant and antidiabetic potential, and erythrocytes’ protection and effects on Caco-2 cells. Twenty-two phenolic compounds were identified using high-performance liquid chromatography with diode-array detection. Hydroxycinnamic acids were the most predominant in both the non-colored fraction and total extract, while cyanidin-3-O-rutinoside was the main anthocyanin found in the colored fraction. The total extract was the most effective against 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, and superoxide radicals, and in the inhibition of α-glucosidase enzyme. The colored fraction revealed the best activity against hemoglobin oxidation and hemolysis. Regarding to Caco-2 cells, the colored extract exhibited the highest cytotoxic effects, while the total extract was the most efficient in protecting these cells against oxidative damage induced by tert-butyl hydroperoxide.

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Section: Resultsmentioning

confidence: 99%

“…Considering other fruit extracts, Saco extracts exhibited more potential to inhibit hemolysis than aqueous extracts of strawberry fruits ( Arbutus unedo L.) (IC 50 = 430.00 µg/mL) [ 26 ]. Furthermore, the colored fraction displayed similar activity to methanolic extracts of grape fruits (Ruby Cabernet) (IC 50 = 11.62 µg/mL) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

et al. 2018

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“…Despite their protective potential, Saco revealed to be 104 times less effective than quercetin control (the most efficient phenolic for erythrocytes protection reported until now) analysed in the same conditions (IC 50 = 0.7 μg/mL) (Chisté et al, 2014). Comparatively with other fruits, Saco sweet cherry proved to be five times more efficient than strawberry fruits (Arbutus unedo L.) (IC 50 = 430.00 μg/mL expressed as dried aqueous extract) (Mendes et al, 2011), but six times less effective than Mexican grapes (Ruby Cabernet) (IC 50 = 11.62 μg/mL expressed as dried methanolic extracts) (García-Becerra et al, 2016).…”

Section: Roomentioning

confidence: 91%

Sweet cherries from Fundão possess antidiabetic potential and protect human erythrocytes against oxidative damage

Gonçalves

Bento

Silva

et al. 2017

Food Research International

105

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Cherries are one of the most appreciated summer fruits due to their attractive colour, sweet taste, high water content, low level of calories and composition in bioactive compounds which, in turn, are important to prevent some pathologies like diabetes, cardiovascular diseases and cancer. In this work we evaluated the phenolic profile and biological potential of 5 varieties of sweet cherries from Fundão region (Portugal) (Saco, Sweetheart, Satin, Maring and Hedelfinger). A total of 23 phenolic compounds were identified by LC-DAD and distributed by the several classes: 6 anthocyanins, 1 hydroxybenzoic acid, 8 hydroxycinnamic acids, 3 flavan-3-ols and 5 flavonols. Maring revealed higher contents in anthocyanins, while Hedelfinger was the richest in non-coloured phenolics. The antioxidant capacity was evaluated against DPPH and nitric oxide radicals. Hedelfinger was the most active against DPPH (IC=12.1μg/mL) and Maring against nitric oxide (IC=140.9μg/mL). Afterwards, antidiabetic capacity was evaluated through the inhibition of α-glucosidase activity, pointing Hedelfinger as the most active (IC=10.3μg/mL). The capacity of Saco extracts to inhibit the hemoglobin oxidation and the hemolysis of human erythrocytes was also evaluated. Both assays revealed a concentration-dependent inhibitory effect (IC=38.6μg/mL and IC=73.0μg/mL, respectively). The results obtained in this study allow us to conclude that sweet cherries possess a great biological potential, and further investigation should be done to promote commercialization and encourage its use in food supplements and in new pharmaceutical and nutraceutical applications.

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“…Considering other fruit extracts, Saco extracts exhibited more potential to inhibit hemolysis than aqueous extracts of strawberry fruits (Arbutus unedo L.) (IC50 = 430.00 μg/mL) [26]. Furthermore, the coloured fraction displayed similar activity to methanolic extracts of grape fruits (Ruby Cabernet) (IC50 = 11.62 μg/mL) [39].…”

Section: Preprintsmentioning

confidence: 98%

“…In addition, they are more frequently exposed to oxygen than other body tissues and so they are more vulnerable to oxidative damage, causing the oxidation of lipids and proteins in the cell membrane, and thus inducing hemolysis [38]. Previous studies already have shown that phenolics present in plants offer therapeutic benefits against oxidative damage in erythrocytes [7,38,39]. Figure 2A shows the protective effects of Saco extracts to avoid hemoglobin oxidation in a concentration-dependent manner.…”

Section: Protective Effects Of Saco Extracts Against Roo• In Human Blmentioning

confidence: 99%

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

Gonçalves¹,

Rodrigues²,

Santos³

et al. 2018

Preprint

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This study aimed to compare three different extracts of Saco sweet cherry, namely non-coloured fraction, coloured fraction and total extract concerning phenolic composition, antioxidant and antidiabetic potential, erythrocytes’ protection and effects on Caco-2 cells. A total of 22 phenolic compounds were identified by LC-DAD. Hydroxycinnamic acids were the most predominant in both non-coloured fraction and total extract, while cyanidin-3-O-rutinoside was the main anthocyanin found in the coloured fraction. The total extract was the most effective against DPPH, nitric oxide and superoxide radicals, and in the inhibition of α-glucosidase enzyme. Finally, the protective effect of the extracts to prevent oxidative damage in human erythrocytes was assessed. The coloured fraction revealed the best activity against hemoglobin oxidation and hemolysis. Regarding to Caco-2 cells, the coloured extract exhibited the most cytotoxic effects, while the total extract was the most efficient in protecting these cells against oxidative damage induced by t-BHP.

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Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

Cited by 19 publications

References 35 publications

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Colored and Non-Colored Enriched Extracts of Sweet Cherry Fruits

Sweet cherries from Fundão possess antidiabetic potential and protect human erythrocytes against oxidative damage

Antioxidant Status, Antidiabetic Properties and Effects on Caco-2 Cells of Coloured and Non-Coloured Enriched Extracts of Sweet Cherry Fruits

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