Immunomodulatory activity and phytochemical analysis of Hibiscus sabdariffa L. flower fractions

Yuliastri, Wa Ode; Diantini, Ajeng; Ghozali, Mohammad; Sahidin, Idin; Isrul, Muhammad

doi:10.7324/japs.2021.1101117

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Meanwhile, the inhibition of AP-1 transactivation and cell transformation, as well as asperulosidic acid, has an antitumorigenic effect. Also, stigmastans can induce a T-helper cell response with immunomodulatory properties (Yuliastri et al, 2021). Ambronal inhibition of protein tyrosine kinase autophosphorylation might be the primary mechanism for the anticancer effect (Qian et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Before microscopic observation, the preparation was allowed to stand for 20 minutes and then rinsed with running water, and the excess water solution was drained by touching a blotting paper on one side of the slide. The microscopic observation of PFCMCs was conducted at 1,000× magnification (Yuliastri et al, 2021).…”

Section: Macrophage Phagocytic Activity Assaymentioning

confidence: 99%

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Immunomodulatory activity of Pepolo (Bischofia javanica Blume) stem bark ethanolic extract in Staphylococcus aureus-stimulated macrophages and anticancer activity against MCF-7 cancer cells

Susanto¹,

Nurfajar²,

Sindia³

et al. 2022

j app pharm sci

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Pepolo (Bischofia javanica Blume) is an Indonesian native plant whose stem bark is widely used as a traditional medicine for various diseases. Therefore, this study aims to determine the chemical profile of the secondary metabolites of the Pepolo stem bark (PSB) extract and its effectiveness as a potential immunomodulatory and anticancer agent. The PSBs were extracted by a reflux technique with 96% v/v ethanol as solvent. The immunomodulatory activity of the PSB extract was evaluated based on its effect on the macrophages of BALB/C mice, while the cytotoxicity and anticancer potential were observed as the PSB extract response on brine shrimp lethality test and MCF-7 cancer cells, respectively. The chemical profiles of the secondary metabolites were analyzed using a Liquid Chromatography-Mass Spectrometry/Mass Spectrometry instrument. The result is that the PSB extract showed its potential as an immunomodulatory and anticancer agent. The toxicity evaluation showed that the PSB extract was classified as a toxic material. More importantly, the PSB extract showed an activity against MCF-7 cancer with lethal concentration 50% (LC 50 ) values of 68.46 µg/mL and an inhibition concentration 50% (IC 50 ) of 362.36 µg/mL, respectively. The chemical evaluation suggested that the terpenoid and polyphenolic compounds are responsible for the immunomodulatory and anticancer mechanisms. In summary, our work showed that the PSB extract is a potential alternative source for the treatment of breast cancer and supports the immune response.

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Section: Discussionmentioning

confidence: 99%

Section: Macrophage Phagocytic Activity Assaymentioning

confidence: 99%

Immunomodulatory activity of Pepolo (Bischofia javanica Blume) stem bark ethanolic extract in Staphylococcus aureus-stimulated macrophages and anticancer activity against MCF-7 cancer cells

Susanto¹,

Nurfajar²,

Sindia³

et al. 2022

j app pharm sci

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Immunomodulators: Chemistry and Analytical Techniques

Sendrayakannan

Kharkar

2023

Natural Immunomodulators: Promising Therapy for Disease Management

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Immunomodulators are substances that either enhance or suppress the immunity of the host. Immunomodulators have been used for ages in Ayurvedic Medicine and Traditional Chinese Medicine. In the surge of modern medicine, many chemically derived substances are used as immunomodulators. Historically, plants present a rich source of these therapeutic agents. Researchers have used these lead structures for exploring the underlying mechanisms of immunomodulation so that newer, safer agents can be designed and used clinically. Microbial sources have also been tried in search of immunomodulators. Chemically, these are a diverse group of substances that act on varied signaling pathways to cause immunomodulation. The involvement of the immune system in many diseases and disorders makes these agents essential in the treatment of these diseases, e.g., cancer. This chapter discusses the chemistry of a selected few commonly known plant-derived immunomodulators along with their biological evaluation methods and provides a broad overview of their therapeutic potential with particular emphasis on the mechanism of immunomodulation.

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Phytochemical Analysis and Immunomodulatory Potential on Diabetic-Infected Tuberculosis by Fruit Etlingera rubroloba A.D. Poulsen

Muhammad¹,

Diantini²,

Halimah³

et al. 2022

Pakistan J. of Biological Sciences

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Immunomodulatory activity and phytochemical analysis of Hibiscus sabdariffa L. flower fractions

Cited by 3 publications

References 8 publications

Immunomodulatory activity of Pepolo (Bischofia javanica Blume) stem bark ethanolic extract in Staphylococcus aureus-stimulated macrophages and anticancer activity against MCF-7 cancer cells

Immunomodulatory activity of Pepolo (Bischofia javanica Blume) stem bark ethanolic extract in Staphylococcus aureus-stimulated macrophages and anticancer activity against MCF-7 cancer cells

Immunomodulators: Chemistry and Analytical Techniques

Phytochemical Analysis and Immunomodulatory Potential on Diabetic-Infected Tuberculosis by Fruit Etlingera rubroloba A.D. Poulsen

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