Immunology of the Newborn Calf: Its Relationship to Colisepticemia*

The Mammary Gland in Mucosal and Regional Immunity

“…Because the amount adsorbed in the first 12 h directly depends on the concentration of the ingested Igs , piglets that suckle first at 12 h obtain threefold less Ig in blood. Morbidity and mortality among suckling ungulates can be traced to low blood immunoglobulin levels (Fey, 1971;Logan et al, 1974) such as in severe combined immunodeficiency Arabian horses (McGuire et al, 1976(McGuire et al, , 1977, resulting from a delay in suckling and/or the availability of Igs in lacteal secretions.…”

Experimental neonatal colibacillosis in cows: serological studies

“…Since the importance of colostrum for the survival of the calf has been established (1,9,15), an evaluation of the three vaccines for production of protective factors in colostrum would be an appropriate indication of vaccine efficiency. Since colostrum-derived antibody had been shown by many investigators to be a critical factor in passive immunity in neonatal calves (2,3,26), it would follow that an effective vaccine should elicit protective antibodies that will predominate in the dam's colostrum.…”

Treatment of Calf Diarrhea: Antimicrobial and Ancillary Treatments

“…61,62 Abomasal pH of the calf is 4.4 at birth 63 and after colostrum ingestion ranges from 5.9 to 7.2 over the first 20 hours of life. 64 The mean preprandial pH is constant between 1.4 and 1.7 after day 5 of life. 65,66 The relatively high pH during the first day of life ensures ingested colostral immunoglobulins are minimally degraded before arriving in the small intestine, which is the site of immunoglobulin absorption.…”