Immunological Studies in Two Children With Recurrent Parotitis

Abstract

In two children with recurrent parotitis, labial salivary gland biopsies showed chronic sialoadenitis. Immunofluorescence studies disclosed deposits of immunoglobulins and complement in juxta-acinar small vessels. Case 1 had gluten enteropathy, IgA deficiency and high titres of antinuclear antibodies (ANA), and in vivo fixation of ANA to nuclei of different cells in lip, skin and jejunum was present. Case 2 showed deposition of IgM in the dermo-epidermal junction of the skin. These findings suggest that autoimmune reactivity and immune complexes may play a role in the pathogenesis of this disorder.

A Boy With Sjogren’s Syndrome and Recurrent Parotitis Who Presented With Suspicious of Allergic and Immunological Disease: Review of the Literature

“…Authors reported that frequency of parotitis episodes was decreased by prophylactic treatment with co-trimoxa- zole. In a study by Friis et al, a 13-year-old girl was reported, who had allergic disorders such as atopic dermatitis, blepharitis, hay fever and IgA deficiency, and gluten enteropathy and elevated ANA titers in association with RP [4]. In a case report by Steuer et al, a 24-year-old man was defined, who had SS, parotitis, ulcerative colitis and IgA deficiency.…”

“…Association of RP with allergic and immunological diseases has been rarely reported [1]. Associations of recurrent parotid with immune deficiencies such as isolated immunoglobulin G 3 (IgG 3 ) deficiency, immunoglobulin A (IgA) deficiency, hypogammaglobulinemia, immunoglobulin M (IgM) deficiency or Xlinked hypogammaglobulinemia and allergic diseases such as atopic dermatitis, blepharitis or hay fever have also been reported [2][3][4][5][6][7][8] (Table 1). In this manuscript, we reported a 4-year-old boy presented with multiple episodes of painful swelling in both parotid glands over a 2-year period and suspicion of allergic disease.…”

Parotiditis crónica recurrente infantil: una revisión actualizada de la literatura

“…El enfoque actual la considera una patología multifactorial y considera factores como enfermedades respiratorias, anomalías anatómicas, alteraciones inmuno-lógicas, factores genéticos, alteraciones oclusales y obstrucción del conducto parotídeo 1,2,4,5,7,8,10,11,[13][14][15][16][17]24,26,[30][31][32] ; la literatura publicada hasta la fecha ofrece estudios más contundentes de factores etiológicos a las enfermedades respiratorias y malformaciones anatómicas que se describen a continuación:…”

Chronisch rezidivierende Parotitis des Kindesalters bei eineiigen Zwillingen Magnetresonanzsialographie

“…1945 schlug Bailey als Ursache eine angeborene Anomalie der Drüsenausführungsgänge vor, eine Theorie, die später von mehreren Autoren erneut favorisiert wurde [7,12,21]. Zusätzlich wurde eine Autoimmunpathogenese vorgeschlagen [6]. Der selbstlimitierende Krankheitsverlauf und das Fehlen detektierbarer Autoantikörper machen diese Theorie jedoch unwahrscheinlich [17].…”