Immunologic Detection of Occult Primary Cancer of the Head and Neck

Hb, Neel; Gr, Pearson; Lh, Weiland; Wf, Taylor; Hh, Goepfert

doi:10.1177/019459988108900217

Cited by 22 publications

(3 citation statements)

References 6 publications

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“…Attempts to use this association between virus and tumour in order to decipher the riddle of the 'unknown primary' have been made before. Neel et al (1981) suggested that elevated anti-EBV antibodies in patients with neck metastases but with no other pathology indicating a primary, may suggest a nasopharyngeal primary.…”

Section: Discussionmentioning

confidence: 99%

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Feinmesser

Freeman

et al. 1992

J. Laryngol. Otol.

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Detection of nasopharyngeal carcinoma primaries in patients presenting with neck node metastases may sometimes demand considerable efforts. By using the ‘ in situ hybridization’ technique, wemanage to identify the Epstein-Barr virus in neck metastases secondary to nasopharyngeal carcinomas. We propose that such identification in neck node metastases where the primary lesion is unknown indicates a nasopharyngeal primary.

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Section: Discussionmentioning

confidence: 99%

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Feinmesser

Freeman

et al. 1992

J. Laryngol. Otol.

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“…Results from previous studies suggested that this test was potentially useful for detecting occult NPC. 1,14,15,18 In this study, sera from 76 patients with metastatic carcinoma from unknown primary sites were tested at the time the patient first presented for examination. Twenty-four of the sera were positive for IgA antibodies to VCA, some at elevated levels.…”

Section: Discussionmentioning

confidence: 99%

Application of epstein‐barr virus (EBV) serology to the diagnosis of north american nasopharyngeal carcinoma

Pearson

Weiland

Neel

et al. 1983

Cancer

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124

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A cooperative study was establishment among a number of institutions in the USA to determine the clinical value of Epstein‐Barr virus (EBV) serology for the diagnosis of different histopathological types of North American nasopharyngeal carcinoma (NPC) including occult primary tumors. One hundred‐twenty‐four patients with confirmed NPC have now been entered into the study. For each patient, anti‐EBV antibody titers were determined at diagnosis and related to the histopathology as classified according to the World Health Organization (WHO). The results suggest that certain anti‐EBV antibodies are of potential value for the diagnosis of undifferentiated types of NPC but not for the well‐differntiated cancer. The IgA anti‐VCA antibody response is the most specific for this disease and of the greatest diagnostic value when used alone or in combination with the anti‐EA test. These tests have also been used succesfully for the detection of occult NPC. These results indicate that these tests can be useful aids to the clinician for the diagnosis of certain histopathologic types of this disease.

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“…In addition, findings from such studies resulted in the identification of antibodies to certain EBV antigens which appeared to be of clinical value for the diagnosis and clinical management of patients with these malignancies. These include IgA antibodies to viral-capsid (VCA) and EBV-induced early antigens (EA), the antibody response to the diffuse (D) and restricted (R) components of the E A complex, antibody to the EBV-induced DNase and antibody to membrane antigens (MA) induced by this virus as measured by the antibody-dependent cellular cytotoxicity (ADCC) assay (Henle et al, 1971(Henle et al, , 1977Chan et al, 1977Chan et al, ,1979Ho et al, 1978;Pearson etal., 1978;Cheng et al, 1980;Neel et al, 1981;Naegele et al, 1982). Although most of these findings were from restrospective studies, the clinical value of the IgA anti-VCA test for the diagnosis of certain histopathological types of nasopharyngeal carcinoma (NPC) including the occult form was recently substantiated by results from a prospective study of North American patients with this disease Pearson et al, 1983).…”

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confidence: 99%

Antibody‐dependent cellular cytotoxicity and disease course in North American patients with nasopharyngeal carcinoma: A prospective study

Pearson

Neel

Weiland

et al. 1984

Intl Journal of Cancer

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It has previously been reported that antibody-dependent cellular cytotoxicity (ADCC) levels determined at diagnosis against Epstein-Barr virus (EBV)-specific membrane antigens (MA) are predictive of disease course following therapy in patients with nasopharyngeal carcinoma (NPC). In general, survival was significantly shorter following therapy in patients with low ADCC titers at diagnosis versus those with high titers. To examine this further, a prospective study on North Americans with different histopathological types of this disease was initiated approximately 5 years ago. The results to date tend to support the conclusions drawn from the retrospective study for patients with the more poorly differentiated types (WHO 2 and WHO 3) of this disease. Over the first 3 years of this study, approximately 75% of the patients in the "high" category have remained clinically disease-free for 3 years or longer as opposed to approximately 35% of the patients in the "low" group. Disease progression rates were calculated to be approximately four times higher in the low group. Similar trends were noted in actual survival rates over a 3-year period. ADCC titers were in general found to be relatively stable in sequential serum samples from the same patient, with some exceptions. With the exceptions, however, changes in ADCC titers also reflected disease course. These results indicate, therefore, that anti-EBV ADCC titers are predictive of disease course in patients with the poorly differentiated types of NPC.

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Immunologic Detection of Occult Primary Cancer of the Head and Neck

Cited by 22 publications

References 6 publications

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Application of epstein‐barr virus (EBV) serology to the diagnosis of north american nasopharyngeal carcinoma

Antibody‐dependent cellular cytotoxicity and disease course in North American patients with nasopharyngeal carcinoma: A prospective study

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