Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma

Garg, Rashi; Gupta, Neelam

doi:10.5468/ogs.2018.61.6.698

Cited by 3 publications

(4 citation statements)

References 7 publications

(5 reference statements)

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“…On immunohistochemistry tumor cells were strongly positive for HMB45, vimentin and S-100. 12 In another study by Khairwa et al, microscopic findings showed an infiltrating tumour in the surrounding tissue, arranged in sheets, nests and lobules with atypical cells showing moderate pleomorphism with abundant eosinophilic cytoplasm and frequent mitosis. On immunohistochemistry, the tumour cells showed positivity for HMB45 and S-100.…”

Section: Discussionmentioning

confidence: 92%

“…Histolopathological findings of our study correlated well with the other studies. 3,[11][12][13] Microscopic examination showed sheets, cords and singly scattered markedly pleomorphic, polygonal with eccentrically placed nuclei with conspicuous nucleoli along with eosinophiliccytoplasm. Focal intranuclear inclusions and frequent mitosis was also seen.…”

Section: Discussionmentioning

confidence: 99%

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Amelanotic melanoma: A challenging cytological diagnosis- A case series

Warsi¹,

Talha²,

Ekram³

et al. 2020

ACHR

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Melanoma is an aggressive malignancy, and early diagnosis and treatment can reduce mortality in patients. A new or changing lesion is the most common warning sign of melanoma. In amelanotic tumors, diagnosis may be delayed. Amelanotic melanoma is a form of melanoma in which malignant cells have little or no pigment. Amelanotic melanoma is classically described as skin coloured but a subset of these tumors are red, pink or erythematous. Typical early lesions present as asymmetrical macular lesions. FNAC may show varied cytomorphology ranging from epithelioid to spindled to plasmacytoid pleomorphic cells with marked anisonucleosis and eosinophilic to basophilic cytoplasm with intranuclear pseudoinclusions and cytoplasmic vacoulations admixed with bi-and multinucleate giant cells. We present a case series of varied presentation of amelanotic melanoma with its cytomorphological features.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Amelanotic melanoma: A challenging cytological diagnosis- A case series

Warsi¹,

Talha²,

Ekram³

et al. 2020

ACHR

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“…The etiology of AMM remains unclear, although it was previously hypothesized that decreased tyrosinase activity and/or melanin transport disorders may constitute possible reasons ( 11 ). AMM has been reported in the skin and the mucosa of the digestive and/or genitourinary tracts ( 1 , 10 ). AMM is a clinically diverse entity without specific characteristics; early lesions are atypical and usually appear as pinkish papules, either as a single lesion or in clusters ( 10 , 12 ).…”

Section: Discussionmentioning

confidence: 99%

“…Malignant melanoma (MM) is a cutaneous and/or extracutaneous tumor that arises from the embryological remnants of neural crest cells/melanocytes, melanoma can happen in eyes and internal organs but rare ( 1 ). The number of recorded new cases in 2018 was 2,87,723, whereas the number of deaths in 2018 in both sexes and across all ages was 60,712 (Globocan 2018, International Agency for Research on Cancer, World Health Organization; https://gco.iarc.fr/today/data/factsheets/cancers/16-Melanoma-of-skin-fact-sheet.pdf ).…”

Section: Introductionmentioning

confidence: 99%

Primary acral amelanotic melanoma: A rare case report

et al. 2020

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The aim of the present study was to present a rare case of primary acral amelanotic malignant melanoma (AMM). A 61-year-old man developed an aggressive tumor in the front part of the sole of his left foot, which continued to increase in size for >1 year. The biopsy results revealed epidermis loss, ulcer formation, and the presence of abundant allotropic tumor cells throughout the dermis, with deeply stained nuclei, light reddish cytoplasm and visible multinucleated giant cells with heterogeneous nuclear division. The tumor cells exhibited partial formation of nests and bundled distribution, and there were no observed pigment particles. The diagnosis was confirmed as AMM based on the findings of the histopathological examination and immunohistochemical staining for Ki67 (+++), Melan-A (+++), human melanoma black 45 (+), CD20 (-), cytokeratin (CK)7 (-) and CK5/6 (-).

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Über ein partiell amelanotisches Schleimhautmelanom der Vulva

et al. 2019

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ZusammenfassungInfolge ihrer häufig partiell oder vollständig amelanotischen Ausprägung, der verdeckten Lokalisation und fehlender Risikofaktoren werden die seltenen vulvo-vaginalen Melanome erst in späteren Stadien diagnostiziert und behandelt. Wir berichten über den Fall einer 70-jährigen Patientin, die sich mit einem Wundgefühl und zwei pigmentierten Läsionen des Labium majus dextrum vorstellte. Nach diagnostischer Exzision bestätigte die histologische Befundung ein partiell amelanotisches mukosales malignes Melanom. Die Nach-Exzision mit Sentinel-Lymphknotenexstirpation ergab das Vorliegen einer maximalen Tumordicke von 1,1 mm. Die erforderliche erweiterte Nach-Resektion erfolgte als vordere Vulvektomie. Das Exzidat der Vulvektomie zeigte weiterhin Reste der In-situ-Komponente bei jedoch tumorfreien Resektionsrändern und Sentinel-Lymphknoten (SLNB 0/1). Die abschließende Tumorklassifikation ergab AJCC (2017) Stadium IB. Nach komplikationsloser Primärheilung befindet sich die Patientin im interdisziplinären dermatologisch-gynäkologischen Nachsorgeprogramm.

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Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma

Cited by 3 publications

References 7 publications

Amelanotic melanoma: A challenging cytological diagnosis- A case series

Amelanotic melanoma: A challenging cytological diagnosis- A case series

Primary acral amelanotic melanoma: A rare case report

Über ein partiell amelanotisches Schleimhautmelanom der Vulva

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