Primary acral amelanotic melanoma: A rare case report

Abstract

The aim of the present study was to present a rare case of primary acral amelanotic malignant melanoma (AMM). A 61-year-old man developed an aggressive tumor in the front part of the sole of his left foot, which continued to increase in size for >1 year. The biopsy results revealed epidermis loss, ulcer formation, and the presence of abundant allotropic tumor cells throughout the dermis, with deeply stained nuclei, light reddish cytoplasm and visible multinucleated giant cells with heterogeneous nuclear division. The tumor cells exhibited partial formation of nests and bundled distribution, and there were no observed pigment particles. The diagnosis was confirmed as AMM based on the findings of the histopathological examination and immunohistochemical staining for Ki67 (+++), Melan-A (+++), human melanoma black 45 (+), CD20 (-), cytokeratin (CK)7 (-) and CK5/6 (-).

Concurrent carcinocythemia, chest wall and right knee joint involvement in Ewing sarcoma

“…ES is the second most common primary malignant bone tumor, mostly affecting adolescents and young adults, comprising 10%–15% of all bone sarcomas 4 . To date, few cases of carcinocythemia have been documented in the literature, occurring especially during the terminal evolution of breast neoplasm, 5,6 small cell lung carcinoma, 7 melanoma, 8 oat cell carcinoma, 9 rhabdomyosarcoma, 10 prostate cancer, 11 and signet ring cell carcinoma 12 . The concurrence of carcinocythemia, chest wall and right knee joint involvement in the present case is a very uncommon event, after the child had responded well to chemotherapy.…”

Misdiagnosis and Clinical Insights into Acral Amelanotic Melanoma—A Systematic Review

“…In AAM, RCM can identify atypical melanocytes at the dermo-epidermal junction and within the epidermis, even in the absence of pigmentation [36,37]. In addition to benign conditions that may mimic AAM, it is important to remember that there are some very aggressive neoplasms with AAM-like features [14,20]. For example, an important differential diagnosis is that between AAM and acral lentiginous melanoma (ALM), given their acral localization but different clinical presentation.…”

Amelanotic melanoma: A challenging cytological diagnosis- A case series

“…Recently immunotherapy is being widely used in melanoma. 17,18 Patients of amelanotic melanoma have a poor prognosis with 5-year survival rate of less than 20%. 3,19 It is seen that the overall survival rate and progression-free survival rate of patients with pigmented melanoma are higher than in patients with amelanotic melanoma.…”