Immunohistochemical Study on the Distribution and Relative Frequency of Endocrine Cells in the Stomach of the Malayan Pangolin, <i>Manis javanica</i>

Nisa, Chairun; Kitamura, Nobuo; Sasaki, Motoki; Agungpriyono, Srihadi; Choliq, Chusnul; Budipitojo, Teguh; Yamada, Junzo; Sigit, Koeswinarning

doi:10.1111/j.1439-0264.2005.00626.x

Cited by 11 publications

(16 citation statements)

References 19 publications

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“…All of the processes of grinding are done in this gizzard, compensating for the lack of teeth. The stomach lumen is lined with a cornified, stratified squamous epithelium and there are numerous glands (a mucous gland spread in three regions, an oxyntic gland and a pyloric gland) responsible for the digestion of their highly chitinous diet (Nisa et al. 2005).…”

Section: A Review Of Non‐avialan Edentate Tetrapodan Taxa With a Tentmentioning

confidence: 99%

Loss of teeth and enamel in tetrapods: fossil record, genetic data and morphological adaptations

Davit-Béal

Tucker

Sire³

2009

Journal of Anatomy

112

128

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Since their recruitment in the oral cavity, approximately 450 million years ago, teeth have been subjected to strong selective constraints due to the crucial role that they play in species survival. It is therefore quite surprising that the ability to develop functional teeth has subsequently been lost several times, independently, in various lineages. In this review, we concentrate our attention on tetrapods, the only vertebrate lineage in which several clades lack functional teeth from birth to adulthood. Indeed, in other lineages, teeth can be absent in adults but be functionally present in larvae and juveniles, can be absent in the oral cavity but exist in the pharyngeal region, or can develop on the upper jaw but be absent on the lower jaw. Here, we analyse the current data on toothless (edentate) tetrapod taxa, including information available on enamel-less species. Firstly, we provide an analysis of the dispersed and fragmentary morphological data published on the various living taxa concerned (and their extinct relatives) with the aim of tracing the origin of tooth or enamel loss, i.e. toads in Lissamphibia, turtles and birds in Sauropsida, and baleen whales, pangolins, anteaters, sloths, armadillos and aardvark in Mammalia. Secondly, we present current hypotheses on the genetic basis of tooth loss in the chicken and thirdly, we try to answer the question of how these taxa have survived tooth loss given the crucial importance of this tool. The loss of teeth (or only enamel) in all of these taxa was not lethal because it was always preceded in evolution by the pre-adaptation of a secondary tool (beak, baleens, elongated adhesive tongues or hypselodonty) useful for improving efficiency in food uptake. The positive selection of such secondary tools would have led to relaxed functional constraints on teeth and would have later compensated for the loss of teeth. These hypotheses raise numerous questions that will hopefully be answered in the near future.

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Section: A Review Of Non‐avialan Edentate Tetrapodan Taxa With a Tentmentioning

confidence: 99%

Loss of teeth and enamel in tetrapods: fossil record, genetic data and morphological adaptations

Davit-Béal

Tucker

Sire³

2009

Journal of Anatomy

112

128

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“…3d). The type, distribution and frequency of endocrine cells in the mucous glands have been reported previously as well as those of the oxyntic and the pyloric glands (Nisa’ et al., 2005).…”

Section: Resultsmentioning

confidence: 57%

“…(1973) and Krause and Leeson (1974) corresponds to the pyloric canal mucous gland (Mg‐C) in the present study. Furthermore, the characteristic of the pyloric glands in Malayan pangolin has been confirmed by the presence of numerous gastrin cells (Nisa’ et al., 2005).…”

Section: Discussionmentioning

confidence: 93%

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Morphological Features of the Stomach of Malayan Pangolin, Manis javanica

Nisa

Agungpriyono

Kitamura

et al. 2010

Anat Histol Embryol

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The morphology of the stomach of Malayan pangolin, Manis javanica was studied at macroscopic, light microscopic, and scanning electron microscopic levels. The stomach of M. javanica was C-shaped with short lesser curvature. At the oesophageal junction, the inner smooth muscle was thickened in the greater curvature side. The entire stomach was lined by a thick cornified stratified squamous epithelium, except at the duct orifices of glands and in the pyloric gland region. The wall of the fundus was thin and devoid of glands. The gastric glands consisted of mucous, oxyntic, and pyloric glands. The mucous glands were observed in the lesser curvature (Mg-L), in the greater curvature (Mg-G), and in the pyloric canal (Mg-C) respectively. The oxyntic glands were organized into gland mass, making an oval mound elevated to the gastric lumen, in the middle of the greater curvature. The oxyntic gland mass has a single common duct with opening directed to the pyloric side. This duct was surrounded by mucus gland (Mg-G). The pyloric glands were located caudal to the pylorus. There was no sphincter at the pyloric-duodenal junction. Large mucosal protuberance, the torus pyloricus was observed in the side of the lesser curvature of the pyloric canal. In the lumen of pyloric canal region, numerous spines and small pebbles were observed. The muscle layers in the wall of this region were considerably thickened. The present results on the stomach of M. javanica are thought to be closely related to the toothless and eating habits of this animal species.

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“…They synthesise various hormones and play regulatory roles in the physiological functioning of the digestive system (Bell, 1979). Previous studies have described the types and distribution of endocrine cells in the gastrointestinal tracts of a wide array of mammals, including sheep (Calingasan et al., 1984), goats (Calingasan et al., 1986), cattle (Kitamura et al., 1985); Philippine carabao, Bubalus bubalis (Baltazar et al., 1998); fallow deer, Dama dama L (Ceccarelli et al., 1995); lesser mouse deer, Tragulus javanicus (Agungpriyono et al., 1994); babirusa, Babyrousa babyrussa (Agungpriyono et al., 2000), pigs (Ito et al., 1987) and Malayan pangolin, Manis javanica (Nisa et al., 2005). However, the morphophysiology of the gastrointestinal tract of the barking deer has not yet been fully examined.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Endocrine Cells in the Gastrointestinal Tract of the Barking Deer, Muntiacus muntjak

Adnyane

Zuki

Noordin

et al. 2011

Anatomia, Histologia, Embryologia

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The morphology, distribution and relative frequencies of endocrine cells in the gastrointestinal tract of the barking deer (Muntiacus muntjak) were investigated. The immunohistochemical method employed used seven types of antisera against chromogranin, serotonin, gastrin, cholecystokinin, somatostatin, glucagon and insulin. Chromogranin and serotonin immunoreactive (IR) cells were found throughout the gastrointestinal tract. Conversely, gastrin-IR cells were only found in the oxyntic gland, pyloric gland and duodenum, while cholecystokinin-IR and somatostatin-IR cells were detected in the oxyntic gland, pyloric gland and small intestines. Somatostatin-IR cells were also seen in the caecum. Glucagon-IR cells were found in all parts of the gastrointestinal tract apart from the colon and rectum. No insulin-IR cells were found in the gastrointestinal tract of this species. The cells in the small intestine were generally spindle shaped with long cytoplasmic processes ending in the lumen (open type), while in the stomach and large intestine, they were occasionally round or spherical in shape (closed type). An uncommon distribution pattern of endocrine cells in the gastrointestinal tract of the barking deer was noted for cholecystokinin- and glucagon-IR cells.

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Immunohistochemical Study on the Distribution and Relative Frequency of Endocrine Cells in the Stomach of the Malayan Pangolin, Manis javanica

Cited by 11 publications

References 19 publications

Loss of teeth and enamel in tetrapods: fossil record, genetic data and morphological adaptations

Loss of teeth and enamel in tetrapods: fossil record, genetic data and morphological adaptations

Morphological Features of the Stomach of Malayan Pangolin, Manis javanica

Immunohistochemical Study of Endocrine Cells in the Gastrointestinal Tract of the Barking Deer, Muntiacus muntjak

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