Immunohistochemical study of p53, Ki-67, epidermal growth factor receptor, and sex-determining region Y-box 2 in squamous cell carcinoma of tongue

Bhayekar, Pallavi D; Gaopande, Vandana L.; Joshi, Avinash R; Jadhav, Amruta B

doi:10.4103/2468-838x.196089

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…EGFR positivity in OSCC cases was 55.7%. Our results were in line with multiple studies by Bernardes et al, 38 Leoncini et al, 39 Bhayekar et al, 40 and Dissanayake 15 who reported 50% (23/46), 56% (28/50), 49%, and 57% (34/60) cases of OSCC positive for EGFR protein on IHC, respectively. In contrast to our results, Shiraki et al 41 reported comparatively lower percentages of EGFR expression in OSCC that is, 39%.…”

Section: Discussionsupporting

confidence: 93%

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Aamir,

Rauf,

Iqbal

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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Background: Increased epidermal growth factor receptor (EGFR) expression has been implicated in several tumors and is associated with increased tumor advancement as well as a potential drug target. The objective of the study was to compare the immunohistochemical expression of EGFR in oral squamous cell carcinoma (OSCC) with oral potentially malignant disorders (OPMDs) and their demographic and pathologic parameters. Methods: This study was a comparative cross-sectional analytical study. It was conducted at the Department of Pathology, Peshawar Medical College, Riphah International University, Islamabad, Pakistan, from March 2021 to February 2022. The sample size was calculated through G Power. Thirty-eight cases of oral squamous cell carcinoma and 38 cases of oral potentially malignant disorders (OPMDs) were included in the study. Statistical analysis was performed using the Statistical Package for Social Sciences version 20.0. χ2 tests and Fisher exact tests were applied to compare categorical variables. Results: Mean age of OSCC was 61.6±13.9, with age range from 26 to 90 years. The male-to-female ratio for OSCC was 2.16:1. Buccal mucosa was the most common site involved (34.2%). The most common histologic type was well-differentiated OSCC (71.05%) followed by poorly differentiated (16%) and moderately differentiated (13.15%). The mean age of OPMDs cases was 59.16 ± 10.81 with a male-to-female ratio of 1:1.2. Buccal mucosa was the common site (55.3%), followed by the tongue (18.4%). The OPMDs with dysplasia were 55.2%, and without dysplasia were 44.8%. A total of 55.7% of cases of OSCC showed positive EGFR expression as compared with 36.9% OPMDs cases. A higher number of low-grade OSCC cases showed increased EGFR positivity (59.3%) as compared with high grade (45.45%). EGFR positivity in OPMD cases without dysplasia was 41.2% as compared with cases with dysplasia (33.3%). The EGFR expression in OPMD cases was higher in the ≤50 age group (P=0.001) and in females (P=0.032), which was statistically significant. Conclusions: EGFR expression by Immunohistochemistry may not be a helpful prognostic marker to determine the risk of OPMDs progressing to higher grades of dysplasia or invasive cancer. However, further studies relating this tumor marker to stage, lymph node metastasis, hematogenous metastasis, survival outcomes, and treatment response may give useful information regarding the utility of this marker.

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Section: Discussionsupporting

confidence: 93%

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Aamir,

Rauf,

Iqbal

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…33 The present study showed that, positive SOX2 expression was in favor of advanced stage (T2) in SCC cases, although the relationship was a near significant (p = 0.063). Association with advanced stage was also reported in other tumors such as oral SCC 34 and head and neck cancer. 35 This could be explained by the role of SOX2 in promoting cancer cell migration and invasion.…”

Section: Discussionsupporting

confidence: 56%

Immunohistochemical expression of SOX2 in non‐melanoma skin cancer

Abdou

Mostafa

Gafar

et al. 2021

J of Cosmetic Dermatology

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Background Basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC) are the most common non‐melanoma skin cancer (NMSC). SOX2 is a transcription factor that acts on various phases of embryonic development and its overexpression in many tumors has been reported. Aim This work aimed to evaluate the possible role of SOX2 in pathogenesis of non‐melanoma skin cancer through its immunohistochemical assessment in BCC and SCC compared to normal skin and correlating its expression with the established prognostic factors. Methods The investigated cases were 24 BCC, 21 SCC, and 26 normal skin specimens. Results SOX2 was not expressed in normal skin, but it was upregulated in SCC (85.7%) and BCC (66.7%), with a significant difference between malignant cases and normal skin (p < 0.001). However, SOX2 expression did not differ between SCC and BCC. SOX2 expression was associated with large‐sized tumors in all malignant cases (BCC plus SCC) (p = 0.02) and in SCC (p = 0.043) alone together with its liability to be expressed in advanced stage in SCC (p = 0.063). Conclusions SOX2 was over‐expressed in cutaneous SCC and BCC without a significant difference. SOX2 may enhance progression of NMSC manifested by its association with large tumor size and advanced stage.

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“…On the other hand, Bhayekar et al 23 results were against the current study, they demonstrated that SOX2 displayed a significant higher expression in advanced stages of OSCC. It was confirmed that SOX2 role in the tumorigenesis is related to its features included its action in the regulation of cell differentiation, proliferation, and survival in many important processes.…”

Section: Discussioncontrasting

confidence: 50%

SOX2 expression inversely correlates with histological grading, nodal metastasis and clinical staging of Oral Squamous Cell Carcinoma

Elmogy¹,

Gaballah²,

Farag³

et al. 2020

JDPO

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Oral squamous cell carcinoma (OSCC) accounts for 95% of entire oral malignant tumors. The development as well as the distribution of many tumors such as OSCC is driven by cancer stem cells (CSCs). Sex determining region Y-box 2 (SOX2) is a functional CSCs marker; it is a transcription factor coding gene, present at chromosomal 3q26.33 area. The current study was conducted to evaluate SOX2 immunohistochemical expression in OSCC in addition to correlation of its expression in various histologic grades and the existing clinical parameters. Paraffin blocks tumor tissues from forty patients of OSCC were utilized to assess SOX2 immunohistochemical expression. The present study demonstrated that SOX2 expression displayed highly significant inverse association with histologic differentiation of OSCC (P=0.001), clinical stages (P=0.007) and lymph node metastases (LNM) (P=0.035). The current study recommended that, SOX2 expression might be utilized as a prognostic predictor for OSCC, and might help in establishment of the diagnosis as well as proper selection of therapeutic modality of cancers.

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Immunohistochemical study of p53, Ki-67, epidermal growth factor receptor, and sex-determining region Y-box 2 in squamous cell carcinoma of tongue

Cited by 5 publications

References 3 publications

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Immunohistochemical Expression of Epidermal Growth Factor Receptor (EGFR) in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

Immunohistochemical expression of SOX2 in non‐melanoma skin cancer

SOX2 expression inversely correlates with histological grading, nodal metastasis and clinical staging of Oral Squamous Cell Carcinoma

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