Immunohistochemical study association between human herpesvirus 8 and multiple myeloma

Abstract

Multiple myeloma (MM) is a plasma cell neoplasm characterized by a clonal proliferation of plasma cells that produce a monoclonal protein and involve the skeleton at multiple sites. Although human herpesvirus-8(HHV-8) has been implicated in pathogenesis of disease, but this role is not clear. The aim of this study was to show direct evidence of HHV-8 in bone marrow tissue of MM patients with use of immunohistochemical method. Standard immunohistochemstry was performed with HHV-8 marker on formalin fixed paraffin embedded bone marrow tissue in 30 MM cases and 30 subjects with normal bone marrow tissue. Slides were examined for nuclear immunoreactivity by two pathologists. The data were analyzed with 2 x 2 contingency tables and Fischer's exact test, also differences with P-value under 0.05 (P <or= 0.05) was considered statistically significant. Nuclear immunoreactivity for HHV-8 was detected in four patients (13.3%) with MM but was not detectable in any normal bone marrow cells. Fisher exact test showed no difference for HHV-8 immunoreactivity between two groups of case and control (P = 0.11). Our finding demonstrated that HHV-8 infection did not seem influence on pathogenesis of multiple myeloma.

Global patterns and trends in multiple myeloma incidence: Age, period and birth cohort analysis

“…Virtually all MM patients are preceded by a precursor disease (PD), being monoclonal gammopathy of uncertain signi cance (MGUS) the most frequent PD [6] . Previous studies have suggested that radiation exposure, chronic in ammation, heredity, virus infection and gene mutation may be related to the pathogenesis of MM [7][8][9][10] . The recognition of other risk factors such as lifestyle, dietary habit, also seems important [11] .…”

Is There Any Relationship between Human Herpesvirus-8 and Multiple Myeloma?

“…IL-6 is a survival factor of plasma cells and a significant growth factor for myeloma cells [22,23]. However, some other studies have not found any connection between HHV-8 and multiple myeloma [24][25][26]. These conflicting results emphasize the necessity for more research on this issue.…”

Multiple Myeloma in Horses, Dogs and Cats: A Comparative Review Focused on Clinical Signs and Pathogenesis

“…Recurrent infections or antigen stimulation have been proposed as predisposing factors, although epidemiological studies have not been confirmed this association [46]. Infections with several virus diseases in human patients appear related to an elevated MM risk, although some data do not support a potentially causal relationship between these infections and MM [46][47][48][49][50]. In cats, a link between MM and virus such as feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) has not been identified, but a diagnosis of the disease among sibling suggests a familiar association [29].…”