Immunohistochemical Identification of Generalized AA-Amyloidosis in a Mountain Gazelle (<i>Gazella gazella</i>)

Linke, Reinhold P.; Hol, P. R.; Geisel, O.

doi:10.1177/030098588602300110

Cited by 25 publications

(10 citation statements)

References 4 publications

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“…Dorcas ceylanların-da amiloidozun genellikle kronik enfeksiyonlar sonucunda geliştiği [4] , ancak genetik predispozisyonun da önemli olabileceği bildirilmiştir [2] . Bir dağ ceylanı [6] ve bir Arap ceylanındaki [5] amiloidozun sebebinin ise idiyopatik olduğu öne sürülmüştür. Çeribaşı ve ark.…”

Section: Tartişma Ve Sonuçunclassified

“…Dağılımına göre sistemik ve lokal, patogenezine göre primer ve sekonder olarak sınıflandırılmaktadır [2] . Amiloidoz yabani hayvanlardan Sibirya kaplanlarında, vizonlarda (mink), siyah bacaklı kediler ve siyah bacaklı gelinciklerde [2] , çitalarda [3] , Dorcas ceylanında [4] , Arap ceylanında [5] , dağ ceylanında [6] , Rocky dağı büyük boynuzlu koyunlarında [7] , tavşanlarda [8] , aslanlarda [9] , kuğularda ve kınalı kekliklerde [10,11] , deniz aslanı [12] , yunus [13] ve balinalarda [14] bildirilmiştir.…”

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Bir Ceylanda (Gazella gazella) Generalize Reaktif Amiloidoz Olgusu

Özdemir¹,

Hatıpoğlu²,

Karaman³

2013

Kafkas Univ Vet Fak Derg

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ÖzetBu raporda 1.5 yaşında, erkek bir dağ ceylanında saptanan generalize reaktif amiloidozis tanımlandı. Makroskobik incelemede karın boşluğundaki serozalarda hiperemi ve rumende ise kenarları kanamalı 7 cm çapında ülser belirlendi. Her iki böbreğin yüzeyinde 1-2 mm büyüklüğünde boz-beyaz renkte odaklar gözlendi. Mikroskobik incelemelerde böbreklerde glomerulus, tubulus ve akıtıcı kanal bazal membranları ve damar duvarlarında, dalakta foliküllerde, karaciğerde Disse aralığında ve ince barsaklarda lamina propriyada pembe renkte, homojen ve amorf yapıda birikimler gözlendi. Bu birikimlerin Kongo kırmızısı ile tuğla kırmızısı renkte boyandıkları, potasyum permanganat ile muamele edildikten sonra Kongo kırmızısı ile boyanmadıkları görülerek AA-amiloidoz (sekonder amiloidozis) olduğu kanısına varıldı. %10'luk formaldehitte bulunan stok doku parçalarının Lugol ve sülfirik asitle muamele edilmeleri sonucunda amiloid birikimlerinin koyu mavi renkte oldukları gözlendi. Rumende ülserasyonla birlikte generalize amiloidoz saptanan bu olguda, amiloid birikimlerinin makroskobik olarak sadece taze dokularda değil formaldehit solüsyonunda tespit edildikten sonra da gösterilebileceğine dikkat çekilmiştir. Anahtar sözcükler: Generalize amiloidozis, Ceylan, Patoloji Generalized Reactive Amyloidosis in a Gazelle (Gazella gazella) SummaryThis report was described generalized amyloidosis in a male gazelle, 1.5 years old. In necropsy, hyperaemia on all the serosal surfaces in abdomen, a hemorrhagic ulcer, 7 cm in diameter, on mucosa of rumen, and whitish colored foci, 1-2 mm diameter, on the surfaces of both kidneys were present. Microscopically, there were homogenous pink depositions in the glomeruli, intertubular interstitium, tubular basement membranes and walls of blood vessel in kidney, lymphoid follicles in spleen, space of Disse in liver and lamina propria of the small intestine. These deposits were seen brick-red color stained with Congo red on tissue sections, but these were not stained with Congo red after treated with potassium permanganate. For this reason, AA (secondary) amyloidosis was evaluated. When stock tissue samples stored in 10% formalin were treated with Lugol and acid sulphuric, amyloid depositions were seen as dark blue. Generalized reactive amyloidosis with ulceration in the rumen was diagnosed. Amyloid deposits in the tissues are not only fresh tissue but also tissue stored formalin can be determined as a macroscopic.

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Bir Ceylanda (Gazella gazella) Generalize Reaktif Amiloidoz Olgusu

Özdemir¹,

Hatıpoğlu²,

Karaman³

2013

Kafkas Univ Vet Fak Derg

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“…15 AA amyloidosis occurs in a wide variety of domestic animal species including canine, equine, bovine, avian, and less frequently porcine and feline. 4,7,12,13,20,36,48 This type of amyloidosis has also been documented in various wild mammalian and avian species such as cheetah (Acinonyx jubatus), 16,24 Siberian tigers (Panthera tigris altaica), 35 mink (Mustela vison), 27 Dorcas gazelle (Gazella dorcas), 32 mountain gazelle (Gazella gazella), 21 and anatidae. 34 Among small ruminants, AA amyloidosis has been reported in wild bighorn sheep (Ovis canadensis) 11 and Dall sheep (Ovis dalli); 18 however, descriptions in domestic sheep Ménsua, Carrasco, Bautista, Biescas, Fernández, Murphy, Weiss, Solomon, and Luján and goats are rare and normally refer to single cases.…”

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confidence: 90%

“…1-15) and II (Nos. [16][17][18][19][20][21] were selected for the presence of macroscopic renal lesions compatible with AA amyloidosis (see results). For group I, the available samples included only kidney, lungs, heart, and sometimes liver and spleen.…”

Section: Animals and Samplesmentioning

confidence: 99%

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Ménsua

2003

Veterinary Pathology

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Abstract. We describe the main pathologic changes in small ruminants affected by AA amyloidosis, together with the partial sequence of the protein involved. Twenty-one sheep and one goat were selected for presenting macroscopic kidney lesions compatible with systemic amyloidosis. Available tissue samples were studied by histologic, immunopathologic, and ultrastructural means. Renal lesions were characterized grossly by pale cortical surfaces with scattered, miliary, whitish-yellow foci and on cut cortical surfaces by straight, whitish-yellow striations. Gangrenous pneumonia was observed in 16 out of 21 affected sheep (76.2%), although other chronic inflammations were also observed. Amyloid was detected in all grossly affected kidneys using Congo red staining, lesions being most remarkable in glomeruli, affecting 95.5% of animals studied. Congophilic deposits were also observed in intertubular interstitium (68.2%) and medulla (57.1%). All amyloid-affected animals presented proximal convoluted tubule lesions, mostly characterized by an increase in diameter and by hyaline granular degeneration that were responsible for the macroscopic appearance of the kidney. Histologically, amyloid was also seen in blood vessels, spleen, liver, lymph nodes, gastrointestinal tract, and adrenal glands. All amyloid deposits demonstrated greenish-yellow birefringence with polarized light, and the antisera prepared against goat amyloid extracts specifically reacted with birefringent congophilic deposits of both sheep and goats. Ultrastructurally, these deposits were formed by masses of straight, nonbranching fibrils located predominantly in the basement membranes of glomerular capillaries and in the mesangium. Partial sequence of the protein in sheep and goats indicated a high degree of homology with the previously reported sequence of sheep Serum Amyloid A.

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“…AA amyloidosis is also reported in a wide variety of domestic animal species including canines, equines, bovines, avian species, porcines, felines, sheep and goats (Jakob, 1971;Johnson & Jamison, 1984;Hayden et al, 1988;Zschiesche & Jakob, 1989;DiBartola, et al, 1990;Blunden & Smith, 1992;Seifi et al, 1997;Landman, 1998;Ménsua et al, 2003). It is described in association with different chronic diseases, in captive cheetah (Acinonyx jubatus), Siberian tigers (Panthera tigris altaica), mink (Mustela vison), black-footed cats (Felis nigripes), black-footed ferrets (Mustela nigripes), Dorcas gazelle (Gazella dorcas), mountain gazelle (Gazella gazella), bighorn and Dall's sheep, free living lioness and in swans and other anatidae (Panthera leo) (Hadlow & Jellison, 1962;Sato et al, 1981;Kingston et al, 1982;Linke et al, 1986;Rideout et al, 1989;Munson, 1993;Nieto et al, 1995;Papendick et al, 1997;Schulze et al, 1998;Williams et al, 2005;Garner et al, 2007;Terio et al, 2008). It is reported in association with chronic lymphoplasmacytic gastritis in the cheetahs and as idiopathic in the Siberian tigers.…”

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confidence: 99%

Amyloidosis in Domestic Animals: Pathology, Pathogenesis, Gross and Microscopic Lesions and Clinical Findings

Woldemeskel¹

2011

Amyloidosis - Mechanisms and Prospects for Therapy

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Immunohistochemical Identification of Generalized AA-Amyloidosis in a Mountain Gazelle (Gazella gazella)

Cited by 25 publications

References 4 publications

Bir Ceylanda (Gazella gazella) Generalize Reaktif Amiloidoz Olgusu

Bir Ceylanda (Gazella gazella) Generalize Reaktif Amiloidoz Olgusu

Pathology of AA Amyloidosis in Domestic Sheep and Goats

Amyloidosis in Domestic Animals: Pathology, Pathogenesis, Gross and Microscopic Lesions and Clinical Findings

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