Pathology of AA Amyloidosis in Domestic Sheep and Goats

Ménsua, C.

doi:10.1354/vp.40.1.71

Cited by 3 publications

(3 citation statements)

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“…For automated sequence analysis by Edman degradation, the protein band was transferred onto a polyvinylidine difluoride (PVDF) membrane and placed in the blot cartridge of an ABI Model 494 Procise gasphase sequencer (Applied Biosystems, Foster City, CA). 17…”

Section: Methodsmentioning

confidence: 99%

Systemic AA Amyloidosis in the Common Marmoset

et al. 2005

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The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective analysis of archived hematoxylin and eosin-stained tissue sections and clinical records was conducted at the New England Primate Research Center on 86 marmosets more than 1 year of age that were euthanized during the past decade because of morbidity and failure to thrive. Approximately 17% (15 of 86) were found to have amyloid deposits in one or more organs, including the liver, adrenal glands, kidneys, and intestine. This material was shown by amino acid sequence analysis to be composed of serum amyloid A (SAA)-related protein. This type of amyloidosis, designated AA or "secondary," is associated typically with an inflammatory process that induces elevated levels of the SAA amyloidogenic precursor molecule. Notably, there were no significant pathologic differences or other distinguishing features in animals with amyloid versus those without; furthermore, on the basis of the limited number of serum specimens available for analysis, the SAA concentrations in the two groups were comparable, thus suggesting the possible inheritable nature of the disorder. In this respect, the common marmoset provides a unique experimental model for study of the pathogenesis and treatment of AA and other forms of systemic amyloidosis.

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Section: Methodsmentioning

confidence: 99%

Systemic AA Amyloidosis in the Common Marmoset

et al. 2005

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“…3 Amyloidosis associated with chronic infections is caused by deposition of fibril-forming fragments of serum amyloid A (SAA) and is the most frequent form of amyloidosis in ruminants. 19,36 Amyloidosis has been associated with E. rhusiopathiae but has not been reported in sheep, although amyloidosis affecting the liver, kidneys, and gut has been described in goat kids with chronic polyarthritis and a bronchopneumonia. 34 No organisms were isolated from the joints, but Mannheimia haemolytica was grown from the lungs.…”

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Erysipelothrix rhusiopathiae Infection in Lambs

2014

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Polyarthritis caused by Erysipelothrix rhusiopathiae is a relatively common infection in lambs characterized by low mortality and high morbidity. E. rhusiopathiae is a ubiquitous Gram-positive bacterium that is both a commensal and a pathogen of vertebrates. The disease was studied during an outbreak in a Norwegian Spæl sheep flock. In the acute phase, 48 of 230 (20%) lambs developed clinical signs and 4 died (1.7%). One acute case was necropsied and E. rhusiopathiae was cultured from all major organs investigated and from joints. There was a fibrinous polyarthritis, increased presence of monocytes in vessels, and necrosis of Purkinje cells. Sixteen of the diseased animals (33%) developed a chronic polyarthritis. Eight of these lambs were necropsied; all had lesions in major limb joints, and 3 of 8 also had lesions in the atlanto-occipital joint. At this stage, E. rhusiopathiae was cultured only from the joints in 7 of 8 (87.5%) lambs, but by real-time polymerase chain reaction, we showed persistence of the bacterium in several organs. Pulsed-field gel electrophoresis typing of the bacterial isolates indicated that the same strain caused the acute and chronic disease. Five of 6 (83%) chronically affected animals had amyloidosis of the spleen, and 6 of 8 (75%) had amyloidosis of the liver. All chronically affected animals had a glomerulonephritis, and 6 of 8 (75%) had sparse degeneration in the brain. Ceruloplasmin and haptoglobin were significantly increased in the chronically diseased lambs. These results show that chronic ovine erysipelas is not restricted to joints but is a multisystemic disease.

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“…In animals, at least eight different diseases associated to misfolded proteins or amyloid precursors have been described (Mensua et al, 2003). These diseases, called amyloidosis may present as localized or systemic disorders (Sipe et al, 2012) with symptoms depending on the tissues where amyloid are depositted.…”

Section: Prion-like Diseases In Animalsmentioning

confidence: 99%