Immunoglobulins and complement in crevicular fluid, serum and saliva in man

Opsonophagocytic Effect of Antibody Against Recombinant Conserved 40‐kDa Outer Membrane Protein of Porphyromonas gingivalis

“…Both immunoglobulin and complement components have been identified in crevicular fluid. [55][56][57] Nisengard and Jarrett 58 reported that subgingival bacteria were coated in vivo with immunoglobulin and complement.…”

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

“…A significant amount of immunoglobulins in the synovium in RA and in the gingiva in periodontal disease is produced locally by plasma cells at the diseased sites [9,[19][20][21][22] Therefore, determination of local immunoglobulin and immune complex production as well as circulating immunoglobulins in RA and periodontal disease may further increase our knowledge of the pathogenesis of these diseases. In order to better understand the distinct similarities between RA and periodontitis, we are planning to study the local and systemic production of immunoglobulin and immune complex in both RA and specific periodontal diseases such as juvenile periodontitis and rapidly progressive periodontitis using large patient groups.…”

Serum Complement-Fixing Antibodies in Human Dental Caries

“…If streptococcal antibodies act through saliva, then IgG antibodies could participate since IgG is found in whole saliva [Brandtzaeg, 1965;Lehner et al, 1967]. How ever, both IgG and IgM can reach the teeth through crevicular fluid which contains very much larger amounts of IgG and IgM than saliva, and thus could participate in the immune response to streptococci [Brandtzaeg, 1965;H olmberg and Killander, 1971; Shillitoe and Lehner, 1972], Salivary antibodies were not measured in this investiga tion and the role of secretory antibody in caries immunity remains to be elucidated.…”