Immunogenicity of adenovirus and DNA vaccines co-expressing P39 and lumazine synthase proteins of Brucella abortus in BALB/c mice

Lin, Ge; Yang, Jutian; Wei, Shaozhong; Chen, Shien; Huo, Shengdong; Ma, Zhiyong

doi:10.1007/s11250-018-1517-7

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…An adenovirus vector-based vaccine was developed for protection against brucellosis and expressed the p39 and BLS proteins of B. abortus . This vaccine successfully induced strong humoral and cellular immune responses in a mouse model ( 198 ).…”

Section: Immunitymentioning

confidence: 99%

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Dawood,

Elrashedy,

Nayel

et al. 2023

Front. Vet. Sci.

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Brucellosis is considered one of the most hazardous zoonotic diseases all over the world. It causes formidable economic losses in developed and developing countries. Despite the significant attempts to get rid of Brucella pathogens in many parts of the world, the disease continues to spread widely. Recently, many attempts proved to be effective for the prevention and control of highly contagious bovine brucellosis, which could be followed by others to achieve a prosperous future without rampant Brucella pathogens. In this study, the updated view for worldwide Brucella distribution, possible predisposing factors for emerging Brucella pathogens, immune response and different types of Brucella vaccines, genomics and proteomics approaches incorporated recently in the field of brucellosis, and future perspectives for prevention and control of bovine brucellosis have been discussed comprehensively. So, the current study will be used as a guide for researchers in planning their future work, which will pave the way for a new world without these highly contagious pathogens that have been infecting and threatening the health of humans and terrestrial animals.

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Section: Immunitymentioning

confidence: 99%

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Dawood,

Elrashedy,

Nayel

et al. 2023

Front. Vet. Sci.

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“…Antigen-delivery systems, such as attenuated viruses or bacteria, are essential for presenting B. abortus immunogenic antigens to the immune system cells. Recently, Lin et al designed an adenoviral vector expressing both p39 and lumazine synthase proteins of B. abortus , which elicited significant humoral and cellular immune responses, although pre-existing immunity against adenovirus could prevent a vaccine from working ( 165 ). There are several studies using liposomes as Brucella antigen-delivery systems.…”

Section: Other Vaccinesmentioning

confidence: 99%

Evaluation of Brucellosis Vaccines: A Comprehensive Review

Heidary

Dashtbin

Ghanavati³

et al. 2022

Front. Vet. Sci.

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Brucellosis is a bacterial zoonosis caused by Brucella spp. which can lead to heavy economic losses and severe human diseases. Thus, controlling brucellosis is very important. Due to humans easily gaining brucellosis from animals, animal brucellosis control programs can help the eradication of human brucellosis. There are two popular vaccines against animal brucellosis. Live attenuated Brucella abortus strain 19 (S19 vaccine) is the first effective and most extensively used vaccine for the prevention of brucellosis in cattle. Live attenuated Brucella melitensis strain Rev.1 (Rev.1 vaccine) is the most effective vaccine against caprine and ovine brucellosis. Although these two vaccines provide good immunity for animals against brucellosis, the expense of persistent serological responses is one of the main problems of both vaccines. The advantages and limitations of Brucella vaccines, especially new vaccine candidates, have been less studied. In addition, there is an urgent need for new strategies to control and eradicate this disease. Therefore, this narrative review aims to present an updated overview of the available different types of brucellosis vaccines.

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“…Recently, Lin et al., (2018) designed an adenovirus vector based vaccine expressing both p39 and lumazin synthase proteins of B. abortus and applied this combined immunization strategy for Brucella vaccine development. A mouse model study indicated that this vaccine elicited significant humoral and cellular immune responses [111]. It is clear that overexpression of Brucella immunodominant antigens can promote protection efficacy against brucellosis.…”

Section: Main Textmentioning

confidence: 99%

Development of new generation of vaccines for Brucella abortus

Gheibi

Khanahmad

Kashfi

et al. 2018

Heliyon

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Brucella abortus is a Gram-negative facultative and intracellular bacteria, it causes bovine brucellosis, a zoonotic disease that is responsible for considerable economic loss to owners of domesticated animals and can cause problems in otherwise healthy humans. There are a few available live attenuated vaccines for animal immunization against brucellosis; however, these have significant side effects and offer insufficient protective efficacy. Thus, the need for more research into the Molecular pathobiology and immunological properties of B. abortus that would lead to the development of better and safer vaccines. In this paper we have reviewed the main aspects of the pathology and the responsive immunological mechanisms, we have also covered current and new prospective vaccines against B. abortus.

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Immunogenicity of adenovirus and DNA vaccines co-expressing P39 and lumazine synthase proteins of Brucella abortus in BALB/c mice

Cited by 5 publications

References 27 publications

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Evaluation of Brucellosis Vaccines: A Comprehensive Review

Development of new generation of vaccines for Brucella abortus

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