Immunofluorescence Studies in Tinea Versicolor

Sternberg, Thomas H.; Keddie, Frances

doi:10.1001/archderm.1961.01580180115018

Cited by 51 publications

(12 citation statements)

References 6 publications

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“…The autofluorescence of pathogenic fungi is well established (8,9,14,22,25,26). The term autofluorescence denotes a natural or innate fluorescence of fungi.…”

Section: Discussionmentioning

confidence: 99%

Pigmentation and autofluorescence of Candida species after growth on tryptophan media

Chaskes¹,

Phillips²

1974

Can. J. Microbiol.

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Candida albicans and six other medically important Candida species were cultured on glucose–salts–biotin media containing tryptophan as the major nitrogen source. Candida albicans, C. tropicalis, and C. parapsilosis produced a pink pigment; C. krusei, C. pseudotropicalis, and C. gulliermondii formed brown pigments. Pigmentation of C. stellatoidea was variable, some strains produced brown pigments and others a pink pigment. Production of pink pigment was catalyzed by light. Cultures incubated in the dark produced only trace amounts of the pink pigment. Iron enhanced pigment production. Intense autofluorescence was observed for strains producing the brown pigment and weak autofluorescence for strains producing the pink pigment.

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“…The autofluorescence of pathogenic fungi is well established (8,9,14,22,25,26). The term autofluorescence denotes a natural or innate fluorescence of fungi.…”

Section: Discussionmentioning

confidence: 99%

Pigmentation and autofluorescence of Candida species after growth on tryptophan media

Chaskes¹,

Phillips²

1974

Can. J. Microbiol.

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“…Hence, in the early 1980s, a reevaluation of those previous studies instigated among taxonomists an unequivocal acceptance of the genus name Malassezia over that of the genus name Pityrosporum. This was based on the morphology, ultrastructure (25,246), and immunological properties (293,310) of Malassezia yeasts. In addition, (i) microscopic observations of hyphae in skin scales from pityriasis versicolor lesions and (ii) confirmation of hyphal production by P. orbiculare clinical isolates in culture (87,233) confirmed its placement in the genus Malassezia.…”

Section: Taxonomy and Identification Methodsmentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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“…Malassez 4 subsequently described both oval and round spores in scalp scales from patients with dandruff and in recognition of his discovery the genus Malassezia was described in 1889. 8,9 Studying these organisms has always been challenging as they have proved difficult to culture in the laboratory, with variable survival rates in culture and an absolute requirement for lipid supplements. Sabouraud 6 believed that there was a distinct difference between the yeasts that caused pityriasis versicolor and those on scaly scalps, largely because of the presence of hyphae in the former, even though he recognized that the yeast forms were morphologically similar; he named the cause of scalp scaling Pityrosporum malassezii.…”

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confidence: 99%

Malassezia, dandruff and seborrhoeic dermatitis: an overview

Hay

2011

British Journal of Dermatology

109

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From their original description, fungi of the genus Malassezia (previously Pityrosporum) have been associated with dandruff and seborrhoeic dermatitis. The principle evidence on which this connection was based was that the organisms were present, often in high numbers, on the skin in these conditions and that both responded to treatment that inhibited or destroyed Malassezia yeasts. The availability of new tools such as genomic and proteomic analyses has begun to provide a new insight into the pathogenetic mechanisms involved. New evidence shows the production of specific phospholipases on affected skin sites in dandruff and signalling molecules such as malassezin in seborrhoeic dermatitis. It is still not clear why those individuals and skin sites, prone to either disease, are particularly associated with the presence of these marker molecules but these studies are providing clues to the different ways in which organisms, which are normally commensals, interact with human skin.

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Immunofluorescence Studies in Tinea Versicolor

Cited by 51 publications

References 6 publications

Pigmentation and autofluorescence of Candida species after growth on tryptophan media

Pigmentation and autofluorescence of Candida species after growth on tryptophan media

The Malassezia Genus in Skin and Systemic Diseases

Malassezia, dandruff and seborrhoeic dermatitis: an overview

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