Immune System-Related Diseases and Dental Implant Treatment

Zheng, Xiaofei; Mo, Anchun

doi:10.1007/978-3-030-28557-9_7

Cited by 4 publications

(6 citation statements)

References 93 publications

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“…Another factor influencing peri-implant bone loss and dental implant survival is smoking [12,42,[72][73][74][75][76]. According to various studies, smoking has a negative effect on osseointegration [77][78][79][80][81][82][83] and its dose-related impact [84].…”

Section: Smokingmentioning

confidence: 99%

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Factors influencing the failure of dental implants: A Systematic Review

Bazli

khoramabadi

Chahardehi

et al. 2020

jcc

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vascular disease) affecting therapyial preliminary considerations of dental implant treatment. However, in case of HIV-positive patients, the dental implant failure rate would not increase due to affective factors (e.g., prophylactic antibiotic treatment, the administration of active antiretroviral therapy, and control of the CD 4+ T lymphocyte counts). Therefore, these patients have no clinical signs of mobility or infection in this treatment and much more attention should be paid to these patients and they should be treated with controlled oral surgical procedures.

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Section: Smokingmentioning

confidence: 99%

“…The process of peri-implant bone healing is undermined by cigarette smoking [72,80,[92][93][94]. The proliferation of precursor cells that is important for bone healing is inhibited by smoking, which delays the healing process of normal bones.…”

Section: Smokingmentioning

confidence: 99%

Factors influencing the failure of dental implants: A Systematic Review

Bazli

khoramabadi

Chahardehi

et al. 2020

jcc

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“… 7 − 9 Despite its benefits and high success rate over the past few years, a TiZr implant could fail in patients suffering from low bone mineral density (BMD), abnormal wound healing, or having systemic disorders like osteoporosis and diabetes. 10 , 11 Owing to the costs, risks, and patient discomfort of implant failure, improving the implant surface properties is vital for these patients. 1 …”

Section: Introductionmentioning

confidence: 99%

“…7−9 Despite its benefits and high success rate over the past few years, a TiZr implant could fail in patients suffering from low bone mineral density (BMD), abnormal wound healing, or having systemic disorders like osteoporosis and diabetes. 10 Owing to the costs, risks, and patient discomfort of implant failure, improving the implant surface properties is vital for these patients. 1 Researchers address this issue by using surface functionalization strategies, which refer to immobilizing bioactive molecules on the surface for enhancing bone−implant interactions.…”

Section: Introductionmentioning

confidence: 99%

“…In the United States alone, 25.6% of all healthcare-associated infections are related to devices causing a huge financial burden on both individual and public health care systems . Among orthopedic and dental implants, the titanium–zirconium alloy (TiZr) has gained considerable attention owing to its higher fracture toughness and corrosion resistance over other commercially available implants. − Despite its benefits and high success rate over the past few years, a TiZr implant could fail in patients suffering from low bone mineral density (BMD), abnormal wound healing, or having systemic disorders like osteoporosis and diabetes. , Owing to the costs, risks, and patient discomfort of implant failure, improving the implant surface properties is vital for these patients …”

Section: Introductionmentioning

confidence: 99%

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Osteoimmunomodulatory Effects of Enamel Matrix Derivate and Strontium Coating Layers: A Short- and Long-Term In Vivo Study

Rahmati

Frank

Walter

et al. 2020

ACS Appl. Bio Mater.

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Over the past few years, surface modification of implant surfaces has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several strategies for surface functionalization of titanium-based implants, only a few studies have compared the osteoimmunomodulatory effects of ionic nanostructures and biofunctionalization in the same biological model. Enamel matrix derivate (EMD) and strontium are both known for their positive influences on bone cell responses. In this study, we functionalized the titanium–zirconium implant surface with EMD and strontium using an electrochemical cathodic polarization method. Afterward, we evaluated the osteoimmunomodulatory effects of EMD or strontium coated titanium–zirconium implants in the tibia of eight Gray Bastard Chinchilla rabbits. We performed 2 and 3D micro-CT, wound fluid, histologic, and histomorphometric analyses on bone tissues after 4- and 8-weeks of implantation. Although the results could indicate some differences between groups regarding the bone quality, there was no difference in bone amount or volume. EMD stimulated higher ALP activity and lower cytotoxicity in wound fluid, as well as a lower expression of inflammatory markers after 8 weeks indicating its osteoimmunomodulatory effects after implantation. Overall, the results suggested that ionic nanostructure modification and biofunctionalization might be useful in regulating the immune responses to implants.

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