Coating doxycycline on titanium-based implants: Two in vivo studies

Rahmati, Maryam; Lyngstadaas, Ståle Petter; Reseland, Janne Elin; Andersbakken, Ingrid; Haugland, Heidi Straume; López-Peña, Mónica; González‐Cantalapiedra, Antonio; Muñoz, Fernando; Haugen, Håvard Jostein

doi:10.1016/j.bioactmat.2020.05.007

Cited by 23 publications

(26 citation statements)

References 42 publications

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“…Coatings on medical device surfaces, such as drug-eluting stents [ 1 , 2 ], external fixators [ 3 , 4 ] and implants [ 5 , 6 ], are considered as an effective strategy to act as reservoir for the local release of therapeutic agents. Obviously, the required release duration and dosage of a specific drug can vary among different clinical scenarios.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery

Cheng

Long

Chen

et al. 2021

Bioactive Materials

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The therapeutic precision and clinical applicability of drug-eluting coatings can be substantially improved by facilitating tunable drug delivery. However, the design of coatings which allows for precise control over drug release kinetics is still a major challenge. Here, a double-layered silk fibroin (SF) coating system was constructed by sequential electrophoretic deposition. A mixture of dissolved Bombyx mori SF ( bm SF) molecules and pre-made bm SF nanospheres at different ratios was deposited as under-layer. Subsequently, this underlayer was covered by a top-layer comprising Antheraea pernyi SF ( ap SF) molecules (rich in arginylglycylaspartic acid, RGD) to improve the cellular response of the resulting double-layered coatings. Additionally, model drug doxycycline was either pre-mixed with dissolved bm SF molecules or pre-loaded into pre-made bm SF nanospheres at the same amount before their mixing and deposition. The thickness and nanosphere content of the under-layer architecture were proportional to the deposition time and nanosphere concentration in precursor mixtures, respectively. The surface topography, wettability, degradation rate and adhesion strength were comparable within the double-layered coating system. As expected, RGD-rich ap SF top-layer improved cell adhesion, spreading and proliferation compared with bm SF top-layer. Furthermore, the amount and duration of drug release increased linearly with increasing nanosphere concentration at fixed deposition time, whereas drug release amount increased linearly with increasing deposition time. These results indicate that the dosage and kinetics of loaded drugs can be quantitatively tailored by altering nanosphere concentration and deposition time as main processing parameters. Overall, this study illustrates the strong potential of pre-defining coating architecture to facilitate control over drug delivery.

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Section: Introductionmentioning

confidence: 99%

Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery

Cheng

Long

Chen

et al. 2021

Bioactive Materials

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“…The use of antibiotic coatings (such as bacitracin, amoxicillin, doxycycline, gentamycin) on dental implant surfaces could chemically improve molecular and cellular responses and reduce infection rates, facilitating osseointegration [ 63 , 64 ]. As well as acting as a potential factor in the treatment of periodontal diseases, doxycycline is one of the antibiotics that are commonly used to control infection after implant surgery [ 65 , 66 ]; therefore, incorporating this drug into implant surfaces could control the speed of release on the implant site [ 67 ]. In an in vivo study using mice, Ding and colleagues [ 21 ] reported a significant increase in BIC at 4 and 8 weeks in the doxycycline-coated implant group as compared with the HA-coated implants.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review

et al. 2021

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Titanium (Ti) dental implant failure as a result of infection has been established at 40%, being regarded as one of the most habitual and untreatable problems. Current research is focused on the design of new surfaces that can generate long-lasting, infection-free osseointegration. The purpose of our study was to assess studies on Ti implants coated with different antibacterial surfaces, assessing their osseointegration. The PubMed, Web of Science and Scopus databases were electronically searched for in vivo studies up to December 2020, selecting six studies that met the inclusion criteria. The quality of the selected studies was assessed using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) criteria and Systematic Review Center for Laboratory animal Experimentation’s (SYRCLE’s) risk of bias tool. Although all the included studies, proved greater osseointegration capacity of the different antibacterial surfaces studied, the methodological quality and experimental models used in some of them make it difficult to draw predictable conclusions. Because of the foregoing, we recommend caution when interpreting the results obtained.

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“…Furthermore, polarization of the molecule (ampholyte) can be used for attachment to titanium in an electrochemical process. For example, two biomolecules, doxycycline and simvastatin, as coating candidates with such a technique have been reported [ 97 , 98 , 99 , 100 , 101 ].…”

Section: Biomoleculesmentioning

confidence: 99%

“… Coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics via oral administration after the implantation surgery. Reprinted with permission from Creative Commons License (CC BY 4.0) [ 99 ]. …”

Section: Figurementioning

confidence: 99%

Is There a Better Biomaterial for Dental Implants than Titanium?—A Review and Meta-Study Analysis

Haugen

Chen

2022

JFB

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This article focuses on preclinical studies and reviews the available evidence from the literature on dental implant and abutment materials in the last decade. Specifically, different peri-implantitis materials and how surface modifications may affect the peri-implant soft-tissue seal and subsequently delay or hinder peri-implantitis are examined. This review analyzed more than 30 studies that were Randomized Controlled Trials (RCTs), Controlled Clinical Trials (CCTs), or prospective case series (CS) with at least six months of follow-up. Meta-analyses were performed to make a comparison between different implant materials (titanium vs. zirconia), including impact on bone changes, probing depth, plaque levels, and peri-implant mucosal inflammation, as well as how the properties of the implant material and surface modifications would affect the peri-implant soft-tissue seal and peri-implant health conditions. However, there was no clear evidence regarding whether titanium is better than other implant materials. Clinical evidence suggests no difference between different implant materials in peri-implant bone stability. The metal analysis offered a statistically significant advantage of zirconia implants over titanium regarding developing a favorable response to the alveolar bone.

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Coating doxycycline on titanium-based implants: Two in vivo studies

Cited by 23 publications

References 42 publications

Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery

Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery

Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review

Is There a Better Biomaterial for Dental Implants than Titanium?—A Review and Meta-Study Analysis

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