Immune Response of Healthy Adults to the Ingested Probiotic <i>Lactobacillus casei</i> Shirota

Harbige, Laurence S.; Pinto, E.; Allgrove, Judith; Thomas, L.

doi:10.1111/sji.12495

Cited by 36 publications

(30 citation statements)

References 90 publications

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“…Administration of VSL#3 in our study led to a decrease in the production of various cytokines (IL-6, TNF, IL-10) in ex-vivo LPS-stimulated whole-blood cultures. In a recent study, ingestion for 4 weeks of a probiotic that contained Lactobacillus casei led to a reduction in the frequency of IL-6-producing monocytes on ex-vivo LPS stimulation [ 36 ]. However, in some older studies, supplementation with lactobacilli in healthy adults had no effect on IL-6 production on LPS stimulation [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study

et al. 2018

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BackgroundProbiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the host immune responses. However, the available data on the effect of probiotics on these parameters are quite limited.MethodsWe studied the composition of fecal microbiota, using 16S rRNA sequencing, and host immune responses in peripheral blood (plasma cytokine levels, T cell subsets and in vitro cytokine production after stimulation with anti-CD3/CD28 antibody or lipopolysaccharide) in a group of 14 healthy women at three time-points – before and after administration of a probiotic preparation (a capsule of VSL#3, each containing 112.5 billion freeze-dried bacterial cells belonging to 8 species, twice a day for 4 weeks), and 4-weeks after discontinuation of the probiotic administration.ResultsThere was no change in the abundance of various bacterial taxa as well as in the alpha diversity of gut microbiota following administration of the probiotic, or following its discontinuation. Probiotic administration led to a reduction in the relative frequency of circulating Th17 cells, and in vitro production of cytokines in whole-blood cultures in response to lipopolysaccharide stimulation. However, it had no effect on the relative frequencies of Th1, Th2 and T regulatory cells among circulating peripheral blood mononuclear cells, on plasma cytokine levels and on in vitro production of cytokines by T cells.ConclusionsWe found that VSL#3 administration did not lead to any changes in gut flora, but led to a reduction in the frequency of Th17 cells and in the production of pro-inflammatory cytokine on lipopolysaccharide stimulation. These findings suggest that the beneficial anti-inflammatory effect of this preparation in patients with autoimmune and allergic disorders may be related to reduced production of monocyte-derived cytokines rather than to changes in the composition of gut microbiota.Trial registrationNCT03330678, Date of registration 30th October 2017. Retrospectively registered.Electronic supplementary materialThe online version of this article (10.1186/s12876-018-0819-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study

et al. 2018

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“…Probiotics may influence and enhance innate and adaptive immune response 4 . Several studies have reported the immune-modulatory effects of probiotics in humans 5 , 6 . Reduction in the production of inflammatory cytokines 7 , 8 and elevation of intestinal secretory immunoglobulin A (sIgA) were also reported by probiotics administration 9 .…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotics on salivary cytokines and immunoglobulines: a systematic review and meta-analysis on clinical trials

Ebrahimpour-Koujan

Milajerdi

Larijani

et al. 2020

Sci Rep

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Findings on the effects of probiotics on salivary cytokines and immunoglobulines have been conflicting. We aimed to perform a systematic review and meta-analysis on clinical trials that examined the effects of oral intake and local administration of probiotics on salivary cytokines and immunoglobulines in adults. We searched PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar up to April 2020 for all relevant published papers assessing probiotic intakes and salivary cytokines and immunoglobulines. We included all randomized clinical trials that investigated the effect of oral probiotic supplementation or lozenges tablets on inflammatory biomarkers in adults. Studies that reported their effect sizes as mean ± SD or mean ± SEM were included. After excluding non-relevant papers, 8 studies remained in this review. Combining findings from 3 studies with 4 effect sizes, we found no significant reduction in salivary IgA concentrations after oral probiotic supplementation [weighted mean difference (WMD): −0.26; 95% CI: (−0.86, 0.35)]. A significant increase in salivary IL-1β concentrations reached after local probiotic supplementation (WMD: 28.21; 95% CI: 18.42, 38.01); however, no significant changes in salivary IL-6 concentrations after local probiotic supplementation was found (WMD: 0.36; 95% CI: −0.85, 1.56). We observed a significant increase in salivary IL-8 concentrations after local probiotic supplementation (WMD: 31.82; 95% CI: 27.56, 36.08). In case of salivary IL-10 concentrations after local probiotic administration, no significant reduction was seen (WMD: −0.02; 95% CI: −0.10, 0.06). we found that oral and local administrations of probiotics might influence some of salivary cytokines. However, additional clinical trials are required to examine these effects on further pro- and anti-inflammatory cytokines and immunoglobulines.

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“…Harbige et al reported that daily ingestion of a probiotic drink containing Lactobacillus casei strain Shirota increased the salivary IgA1 and IgA2 concentrations in healthy adults. The B‐cell isotype switch to IgA production is controlled by transforming growth factor (TGF)‐β; therefore, it is possible that L. casei strain Shirota induce the production of IgA1 and IgA2 via TGF‐β induction . Further, intake of combined probiotics comprising L. casei and Enterococcus faecalis significantly increased the expression level of TGF‐β in the piglet jejunum in another study .…”

Section: Discussionmentioning

confidence: 97%

“…The B-cell isotype switch to IgA production is controlled by transforming growth factor (TGF)β; therefore, it is possible that L. casei strain Shirota induce the production of IgA1 and IgA2 via TGFβ induction. 27 Further, intake of combined probiotics comprising L. casei and Enterococcus faecalis significantly increased the expression level of TGFβ in the piglet jejunum in another study. 28 In the present study, it can be speculated that the intake of yogurt fermented with L. bulgaricus OLL1073R-1 may also activate the gut mucosal immune system and increase the expression levels of cytokines in the gut.…”

Section: Effects On Mucous Immunity By Intake Of Yogurt Fermented Wmentioning

confidence: 89%

Effects of yogurt fermented withLactobacillus delbrueckiissp. bulgaricusOLL1073R‐1 on the IgA flow rate of saliva in elderly persons residing in a nursing home: A before‐after non‐randomised intervention study

et al. 2017

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Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota

Abstract: Abstract

Cited by 36 publications

References 90 publications

Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study

Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study

Effects of probiotics on salivary cytokines and immunoglobulines: a systematic review and meta-analysis on clinical trials

Effects of yogurt fermented withLactobacillus delbrueckiissp. bulgaricusOLL1073R‐1 on the IgA flow rate of saliva in elderly persons residing in a nursing home: A before‐after non‐randomised intervention study

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