Effects of yogurt fermented withLactobacillus delbrueckiissp. bulgaricusOLL1073R‐1 on the IgA flow rate of saliva in elderly persons residing in a nursing home: A before‐after non‐randomised intervention study

Abstract

Continuous intake of yogurt fermented with L. bulgaricus OLL1073R-1 may help improve the mucosal immune function in elderly people with weakened immune systems.

Dairy starters and fermented dairy products modulate gut mucosal immunity

“…In the same category of patients, L. delbrueckii subsp. bulgaricus OLL1073R-1 fermented milk was shown to increase the concentration of saliva IgA [144,145]. It moreover reduced the risk of infection in the elderly, increasing NK cell activity as well as enhancing the quality of life score [74].…”

Probiotics for the Prevention of Acute Respiratory-Tract Infections in Older People: Systematic Review

“…Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1, a polysaccharide-producing lactic acid bacterial strain, has proven beneficial health effects on older people by preventing infection with influenza A virus subtype H3N2 via increasing the production of H3N2bound salivary IgA [68] and improving the mucosal immune function in elderly people with weakened immune systems [69]. The study by Makino and co-authors [39], which was among the investigated studies in this review and was additionally found in the reference list of included studies [38,53,54], also used this probiotic.…”

Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice

“…It exhibits marked immunemodulatory effects, such as the activation of biological defense mechanisms and natural killer cell activation, through induction of IFN-γ in mice (Makino et al, 2006(Makino et al, , 2010(Makino et al, , 2016. Furthermore, it was reported recently that L. bulgaricus OLL1073R-1 YC increased IgA secretion in saliva in elderly individuals and protected against invasion by foreign antigens and pathogens through the oral mucosa (Yamamoto et al, 2017).…”