Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice

Takahashi, Eiki; Sawabuchi, Takako; Kimoto, Tsunenobu; Sakai, Shio; Kido, Hiroshi

doi:10.3168/jds.2019-16268

Cited by 20 publications

(12 citation statements)

References 35 publications

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“…bulgaricus, L. rhamnosus, L. plantarum, L. casei, etc. (Bae et al, 2018;Kumova et al, 2019;Takahashi et al, 2019), contribute to host defenses against influenza virus infection by boosting host immune responses, suggesting that L. gasseri may also play a beneficial role during influenza infection. In order to verify this hypothesis, we also investigated the role of L. gasseri in influenzainfected mice, following the procedures used for investigating the effects of A. muciniphila.…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

Zhao

Yang

et al. 2021

Front. Microbiol.

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Influenza virus infection can alter the composition of the gut microbiota, while its pathogenicity can, in turn, be highly influenced by the gut microbiota. However, the details underlying these associations remain to be determined. The H7N9 influenza virus is an emerging zoonotic pathogen which has caused the death of 616 humans and has incurred huge losses in the poultry industry. Here, we investigated the effects of infection with highly pathogenic H7N9 on gut microbiota and determined potential anti-influenza microbes. 16S rRNA sequencing results show that H7N9 infection alters the mouse gut microbiota by promoting the growth of Akkermansia, Ruminococcus 1, and Ruminococcaceae UCG-010, and reducing the abundance of Rikenellaceae RC9 gut group and Lachnoclostridium. Although the abundance of Akkermansia muciniphila is positively related to H7N9 infection, the oral administration of cultures, especially of pasteurized A. muciniphila, can significantly reduce weight loss and mortality caused by H7N9 infection in mice. Furthermore, oral administration of live or pasteurized A. muciniphila significantly reduces pulmonary viral titers and the levels IL-1β and IL-6 but enhances the levels of IFN-β, IFN-γ, and IL-10 in H7N9-infected mice, suggesting that the anti-influenza role of A. muciniphila is due to its anti-inflammatory and immunoregulatory properties. Taken together, we showed that the changes in the gut microbiota are associated with H7N9 infection and demonstrated the anti-influenza role of A. muciniphila, which enriches current knowledge about how specific gut bacterial strains protect against influenza infection and suggests a potential anti-influenza probiotic.

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Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

Zhao

Yang

et al. 2021

Front. Microbiol.

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“…Feeding of VA by mice prior to IAV challenge led to a marked reduction in bodyweight loss, and feeding of KB290+VA completely prevented IAV infection-induced bodyweight loss. A reduction in bodyweight loss after treating mice with various LAB species, such as live L. brevis KB290 [ 14 ], L. bulgaricus [ 17 ], L. gasseri [ 6 , 13 ], L. paracasei [ 15 ], L. pentosus [ 8 ], L. plantarum [ 4 , 7 , 10 , 11 , 12 , 16 ], and L. rhamnosus [ 9 ], has been reported previously. A complete maintenance of bodyweight despite IAV infection, as observed in this study, has so far been reported only once after an intranasal pre-treatment of mice with heat-killed L. casei [ 63 ].…”

Section: Discussionmentioning

confidence: 93%

“…Nutrients 2020, 12, 2925 2 of 12 Lactic acid bacteria (LAB) are historically important because of their utility in food preservation and fermentation; they can exert immunomodulatory effects in the respiratory tract and protect the host against IAV infection [4,5]. Previous studies have reported a reduction in IAV-induced weight loss in mice treated with LAB [4,[6][7][8][9][10][11][12][13][14][15][16][17]. However, safety remains a major concern with the use of live microorganisms as probiotics because the potential risks include systemic infection, antibiotic resistance gene acquisition, and gut colonisation interference in neonates [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Oral Administration of Heat-killed Lactobacillus brevis KB290 in Combination with Retinoic Acid Provides Protection against Influenza Virus Infection in Mice

Satomi¹,

Khanum

Miller

et al. 2020

Nutrients

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Influenza virus type A (IAV) is a seasonal acute respiratory disease virus with severe symptoms, and an effective preventive measure is required. Despite many reports describing the potentially protective effects of lactic acid bacteria, few studies have investigated the effects of nutritional supplement combinations. This study reports the effect of the combined intake of heat-killed Lactobacillus brevis KB290 (KB290) and vitamin A (VA) on mice challenged with a sublethal dose of IAV. For 2 weeks, five groups of mice were fed either placebo, KB290, VA, or a combination of KB290 and VA (KB290+VA). After subsequent IAV challenge, bodyweight and general health were monitored for up to 2 weeks. Viral titres were determined in the lungs of animal subgroups euthanised at days 3, 7, and 14 after IAV challenge. A significant loss was observed in the bodyweights of IAV-infected animals from day 1 post-IAV challenge, whereas the mice fed KB290+VA did not lose any weight after IAV infection, indicating successful protection from the infection. Additionally, mice in the KB290+VA group showed the highest reduction in lung viral titres. In conclusion, the combination of KB290 and VA could be a useful food supplement relevant for protection against seasonal influenza virus infection in humans.

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“…In addition, adverse effects after the clinical use of oseltamivir, such as inhibiting the production of viral antigens, leading to the reduction of acquired antiviral humoral immunity and increasing the probability of re-infection [67], have been observed. In order to reduce the impact of adverse effects, Takahashi et al demonstrated that Lactobacillus bulgaricus OLL1073R-1YC has the ability to stimulate host humoral immunity against influenza virus and can assist oseltamivir in the treatment of influenza virus [67]. L-NMMA, nitazoxanide, etc., have emerged to synergistically fight against influenza viruses in order to make the use of drugs more efficient [68].…”

Section: Development and Effects Of Chemical Synthesis Drugs On Influmentioning

confidence: 99%

Development and Effects of Influenza Antiviral Drugs

et al. 2021

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Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development.

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Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice

Cited by 20 publications

References 35 publications

Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection

Short Communication: Oral Administration of Heat-killed Lactobacillus brevis KB290 in Combination with Retinoic Acid Provides Protection against Influenza Virus Infection in Mice

Development and Effects of Influenza Antiviral Drugs

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