Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

Protein-guided biomimetic nanomaterials: a versatile theranostic nanoplatform for biomedical applications

“…Through the enhanced permeability and retention effect (EPR) of solid tumors or surface coupling of targeting ligand, nanocarriers can realize the selective administration of tumor tissue by passive or active targeting to improve the bioavailability of anti-cancer drugs, enhance the therapeutic effect, and reduce the toxic side effects. [93][94][95] Compared with chemical methods to prepare nanocarriers, mineralizationbased methods are characterized by good biocompatibility, facile nature, and low cost, having high feasibility and great potential from laboratory research to clinical application. Moreover, tumor tissues showed significantly different physiological properties, such as slight acidity, hypoxia, GSH overexpression, and enzyme overexpression.…”

Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

“…The bioactivity and stability of encapsulated drugs can also be enhanced by protection from the NPs against rapid metabolism and clearance. 109,110 Moreover, the nano-formulation can contribute to lower toxicity and improved therapeutic efficacy of a drug via the spatiotemporal control of drug release. [111][112][113][114] Drug nanocrystals, also called pure drug NPs, are a versatile tool for the delivery of hydrophobic drugs as a simple coreshell nanostructure.…”

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

“…To conclude, the optimization of size, shape, structure, surface charge or surface chemistry of nanomedicines can endow them with the ability of loading onco-immunological agents (tumor antigens, STING agonists, or ICD inducers) and radio-enhancers to tumors or lymph nodes in a more safe and effective manner. 223–225…”