Protein-guided biomimetic nanomaterials: a versatile theranostic nanoplatform for biomedical applications

Abstract

Over the years, bioinspired mineralization-based approaches have been applied to synthesize multifunctional organic-inorganic nanocomposites. These nanocomposites can address the growing demands of modern biomedical applications. Proteins, serving as vital biological...

Improving the colloidal stability of protein@ZIF-8 nanoparticles in biologically relevant buffers

“…[1][2][3][4][5][6][7][8][9][10][11] Protein encapsulation in ZIF-8 nanoparticles has been demonstrated to protect protein structure and function, and enhance protein activity. [12][13][14] However, the application of protein@ZIF-8 materials in biological applications is limited by the degradation of ZIF-8 in aqueous buffered solutions. 8,9,15 Vasquez-Hernandez et al demonstrated that ZIF-8 degrades in phosphate buffered saline (PBS) due to the chelation of phosphate ions to Zn nodes ultimately causing the de-coordination of ZIF-8.…”