Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Shen, Yingnan; Gwak, Hogyeong; Han, Bumsoo

doi:10.1039/d3an01739g

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2024

DOI: 10.1039/d3an01739g

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Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Yingnan Shen,

Hogyeong Gwak,

Bumsoo Han

Abstract: Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.

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2024

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Cited by 3 publications

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The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

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The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

Arduino,

Andreana,

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et al. 2024

Journal of Drug Delivery Science and Technology

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Size-Controllable and Monodispersed Lipid Nanoparticle Production with High mRNA Delivery Efficiency Using 3D-Printed Ring Micromixers

Hong,

Lee,

Park

et al. 2024

ACS Appl. Mater. Interfaces

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Lipid nanoparticles (LNPs) are gaining recognition as potentially effective carriers for delivery of therapeutic agents, including nucleic acids (DNA and RNA), for the prevention and treatment of various diseases. Much effort has been devoted to the implementation of microfluidic techniques for the production of monodisperse and stable LNPs and the improvement of encapsulation efficiency. Here, we developed three-dimensional (3D)-printed ring micromixers for the production of size-controllable and monodispersed LNPs with a high mRNA delivery efficiency. The effects of flow rate and ring shape asymmetry on the mixing performance were initially examined. Furthermore, the physicochemical properties (such as hydrodynamic diameter, polydispersity, and encapsulation efficiency) of the generated LNPs were quantified as a function of these physical parameters via biochemical analysis and cryo-electron microscopy imaging. With a high production rate of 68 mL/min, our 3D-printed ring micromixers can be used to manufacture LNPs with diameters less than 90 nm, low polydispersity (<0.2), and high mRNA encapsulation efficiency (>91%). Despite the simplicity of the ring-shaped mixer structure, we can produce mRNA-loaded LNPs with exceptional quality and high throughput, outperforming costly commercial micromixers.

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Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma

Xing,

Chen,

Zheng

2024

Open Life Sciences

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Hepatocellular carcinoma (HCC) is among the most common malignant liver tumors. Despite progress in anticancer drugs and surgical approaches, early detection of HCC remains challenging, often leading to late-stage diagnosis where rapid disease progression precludes surgical intervention, leaving chemotherapy as the only option. However, the systemic toxicity, low bioavailability, and significant adverse effects of chemotherapy drugs often lead to resistance, rendering treatments ineffective for many patients. This article outlines how nanoparticles, following functional modification, offer high sensitivity, reduced drug toxicity, and extended duration of action, enabling precise targeting of drugs to HCC tissues. Combined with other therapeutic modalities and imaging techniques, this significantly enhances the diagnosis, treatment, and long-term prognosis of HCC. The advent of nanomedicine provides new methodologies and strategies for the precise diagnosis and integrated treatment of HCC.

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Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Abstract: Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.

Cited by 3 publications

References 206 publications

The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

Size-Controllable and Monodispersed Lipid Nanoparticle Production with High mRNA Delivery Efficiency Using 3D-Printed Ring Micromixers

Research progress of nanoparticles in diagnosis and treatment of hepatocellular carcinoma

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