Immune, endocrine and cardiovascular responses to controllable and uncontrollable acute stress

Isowa, Tokiko; Ohira, Hideki; Murashima, Shuichi

doi:10.1016/j.biopsycho.2005.04.002

Cited by 47 publications

(37 citation statements)

References 39 publications

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“…This parallels prior research where brief psychological stressors induced significant cardiovascular responses but no significant cortisol increase. [55][56][57] The observed decrease most likely reflects the natural diurnal slope, as other authors also concluded. 56 It might be preferable to test subjects in the late afternoon when circadian variation is less prominent.…”

Section: Cortisolsupporting

confidence: 56%

Salt-sensitive men show reduced heart rate variability, lower norepinephrine and enhanced cortisol during mental stress

et al. 2008

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Salt sensitivity (SS) represents a risk factor for essential hypertension, which has been related to enhanced cardiovascular stress reactivity possibly mediated by increased noradrenergic susceptibility. We investigated biophysiological responses to mental stress in salt-sensitive (ss) and salt-resistant (sr) subjects, hypothesizing lower heart rate variability (HRV) and higher cortisol in the ss. A total of 48 healthy normotensive Caucasian men (age 25.6±2.6, body mass index 22.9±2.3) were phenotyped for SS (defined as significant drop in mean arterial pressure43 mm Hg under the low-salt diet) by a 2-week high-versus low-salt diet. Subjects underwent a standardized mental stress task with continuous cardiovascular monitoring before, during and after the test (Finapres; Ohmeda, Louisville, CO, USA). Blood samples were drawn to examine cortisol and catecholamines before, after and 20 min after stress. The task elicited significant increases of systolic blood pressure (SBP), diastolic BP (DBP) and heart rate (HR) and a significant decrease of HRV (all time effects Po0.0001). The ss subjects showed lower norepinephrine (NE) and higher cortisol, indicated by significant group effects (P ¼ 0.009 and 0.025, respectively). HR increased and HRV decreased more in the ss under the stress, shown by significant time by group interactions (P ¼ 0.045 and 0.003, respectively). The observation of a more pronounced HR rise coupled with a greater decrease of HRV in healthy ss men under the influence of brief mental stress confirms their enhanced physiological stress reactivity. The lower peripheral NE may represent an effort to compensate for increased noradrenergic receptor sensitivity. The enhanced cortisol levels are backed by recent genetic findings on HSD11B2 polymorphisms and may promote hypertension.

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Section: Cortisolsupporting

confidence: 56%

Salt-sensitive men show reduced heart rate variability, lower norepinephrine and enhanced cortisol during mental stress

et al. 2008

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“…The LF/HF ratio, as a frequency-based indicator of heart rate variability, reflects the sympathovagal balance (Sleight & Bernardi, 1998). Various studies report a significant increase of the LF/HF ratio in experimental stress situations that is caused by a decrease of the HF component (compared to the LF component), that in turn indicates a predominant state of the sympathetic nervous system under stress (Baert et al, 2012;Hjortskov et al, 2004;Isowa et al, 2006). HPA axis and autonomic nervous system are related (Kemeny, 2003); Stadler et al (2011) as well as Looser et al (2010) found significant correlations between heart rate variability and cortisol awaking response.…”

Section: Sympathetic and Parasympathetic Activitymentioning

confidence: 97%

“…Baert et al, 2012;Hjortskov et al, 2004;Isowa et al, 2006;Takahashi et al, 2005) and that academic self-concept and situational coping are negatively related to students' stress experience (cf. Goetz et al, 2008;Spangler et al, 2002).…”

Section: Research Aims and Hypothesesmentioning

confidence: 99%

Analysis of person-situation interactions in educational settings via cross-classified multilevel longitudinal modeling: illustrated with the example of students’ stress experience

Kärner

Sembill

Aßmann

et al. 2017

FLR

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“…Изменение ряда иммунологических показателей в нашем исследовании доказывает наличие адаптивных ответных реакций на действие стрессорных фак-торов со стороны системы иммунитета. В форми-ровании таких реакций существенную роль игра-ют межсистемные связи посредством активации центральной и вегетативной нервной систем, гормональных механизмов и иммунологических посредников [1,9,16]. Показана ключевая роль диэнцефальных структур, в особенности гипота-ламуса, в развитии начальных нервно-гумораль-ных реакций в ответ на психоэмоциональный стресс [2,14].…”

Section: результаты и обсуждениеunclassified

“…Фагоцитарная активность макро-фагов возрастала, однако острый стресс снижал чувствительность данных клеток к повторному воздействию стрессовых гормонов [5,8,11,12]. Перечисленные реакции системы иммунитета коррелировали с выраженностью реакций кар-диоваскулярной системы: повышение частоты сердечных сокращений, уровней систолическо-го и диастолического артериального давления, уменьшение величины кардиоинтервала [7,9].…”

Section: результаты и обсуждениеunclassified

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

Широлапов¹,

Пятин²,

Лавров³

2014

Med. immunol.

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ОсОбеннОсти иммунОлОгических пОказателей в услОвиях экзаменациОннОгО стрессаШиролапов И.В., Пятин В.Ф., Лавров О.В. ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. СамараРезюме. В условиях воздействия психоэмоциональных стрессоров обеспечивается постоянное тесное взаимодействие нервной, эндокринной и иммунной физиологических регуляторных систем. У 203 студентов вуза изучены особенности клеточных и гуморальных показателей системы имму-нитета при экзаменационном стрессе. Установлено снижение абсолютного и относительного со-держания CD3 + Т-лимфоцитов, субпопуляции клеток с функцией естественной цитотоксичности (CD3 -CD16 + CD56 + и CD3 + CD16 + CD56 + клеток) после экзамена по сравнению с таковым до экзаме-на. Выявлено снижение значений CD3 -CD19 + , CD3 + CD4 + и CD3 + CD8 + лимфоцитов после экзамена относительно контрольного периода измерений. Сывороточные концентрации иммуноглобулинов A, M, G находились в пределах физиологических значений нормы. Изменения иммунологических показателей при остром экзаменационном стрессе зависят от особенностей вегетативных и гормо-нальных реакций человека и в определенных условиях -предельных по интенсивности и длительно-сти -психоэмоциональный стресс может вызвать общие нарушения иммунного реагирования. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3 + T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3 -CD16 + CD56 + and CD3 + CD16 + CD56 + ), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19 + B cells, CD4 + T-helpers and CD8 + T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.

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Immune, endocrine and cardiovascular responses to controllable and uncontrollable acute stress

Cited by 47 publications

References 39 publications

Salt-sensitive men show reduced heart rate variability, lower norepinephrine and enhanced cortisol during mental stress

Salt-sensitive men show reduced heart rate variability, lower norepinephrine and enhanced cortisol during mental stress

Analysis of person-situation interactions in educational settings via cross-classified multilevel longitudinal modeling: illustrated with the example of students’ stress experience

Features of Immune Reactions in Stress Conditions Associated Associated With Exams

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