Immune effects of mesenchymal stem cells: Implications for Charcot–Marie–Tooth disease

Leal, Alejandro; Ichim, Thomas E.; Marleau, Annette M.; Lara, Fabian; Kaushal, Shalesh; Riordan, Neil H

doi:10.1016/j.cellimm.2008.06.003

Cited by 12 publications

(14 citation statements)

References 69 publications

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“…46 In addition to GVHD, MSC therapy has implications in Charcot-Marie-Tooth disease, an inherited neuropathy characterized by demyelination of peripheral nerves. 45 As for the bimodal property of MSC behavior, it appears that the level of expression is key. An abundance of MSCs leads to immunosuppressive behavior, whereas sparse MSC presence induces immunostimulation.…”

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

“…48,49 This is of particular relevance to hematopoietic stem cell (HSC) transplants because T-cell-derived infl ammatory cytokines such TNF-α and IFN-γ suppress hematopoiesis. 45 Therefore, MSCs transplanted along with HSCs can guard them from destruction by infl ammatory cytokines. Furthermore, research has shown that MSCs are capable of producing immune suppressive factors such as HLA-G, prostaglandin E2, IL-10, and TGF-β, which strengthens their anti-inflammatory properties.…”

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

“…45 GVHD induces systemic infl ammation and often results in death of the recipient. 45 The immune properties of MSCs confer them with pharmacological potential in the regulation of conditions such as GVHD and other infl ammatory processes. 46 In addition to GVHD, MSC therapy has implications in Charcot-Marie-Tooth disease, an inherited neuropathy characterized by demyelination of peripheral nerves.…”

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

“…44 It is their anti-infl ammatory properties rather than their potential as stem cells that warrant their fi rst clinical application. 45 One of the most serious concerns regarding bone marrow transplantation is graft-versus-host-disease (GVHD), which is a pathology characterized by an immune response of the maturing donor lymphocytes against antigens of the recipient. 45 GVHD induces systemic infl ammation and often results in death of the recipient.…”

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

“…45 One of the most serious concerns regarding bone marrow transplantation is graft-versus-host-disease (GVHD), which is a pathology characterized by an immune response of the maturing donor lymphocytes against antigens of the recipient. 45 GVHD induces systemic infl ammation and often results in death of the recipient. 45 The immune properties of MSCs confer them with pharmacological potential in the regulation of conditions such as GVHD and other infl ammatory processes.…”

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

See 4 more Smart Citations

Inflammatory mediators: Parallels between cancer biology and stem cell therapy

Patel¹,

Heinrich²,

Reddy³

et al. 2009

JIR

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Infl ammation encompasses diverse molecular pathways, and it is intertwined with a wide array of biological processes. Recently, there has been an upsurge of interest in the interactions between mediators of infl ammation and other cells such as stem cells and cancer cells. Since tissue injuries are associated with the release of infl ammatory mediators, it would be diffi cult to address this subject without considering the implications of their systemic effects. In this review, we discuss the effects of infl ammatory reactions on stem cells and extrapolate on information pertaining to cancer biology. The discussion focuses on integrins and cytokines, and identifi es the transcription factor, nuclear factor-kappa B (NFκB) as central to the infl ammatory response. Since stem cell therapy has been proposed for type II diabetes mellitus, metabolic syndrome, pulmonary edema, these disorders are used as examples to discuss the roles of infl ammatory mediators. We propose prospects for future research on targeting the NFκB signaling pathway. Finally, we explore the bridge between infl ammation and stem cells, including neural stem cells and adult stem cells from the bone marrow. The implications of mesenchymal stem cells in regenerative medicine as pertaining to infl ammation are vast based on their anti-infl ammatory and immunosuppressive effects. Such features of stem cells offer great potential for therapy in graft-versus-host disease, conditions with a signifi cant infl ammatory component, and tissue regeneration.

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Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

Section: Mesenchymal Stem Cell Therapy For Infl Ammatory-mediated Dismentioning

confidence: 99%

See 3 more Smart Citations

Inflammatory mediators: Parallels between cancer biology and stem cell therapy

Patel¹,

Heinrich²,

Reddy³

et al. 2009

JIR

View full text Add to dashboard Cite

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Inflammation in the Pathogenesis of Inherited Peripheral Neuropathies

Groh¹,

Klein²,

Kroner³

et al. 2015

Neuroinflammation

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Efficient cryopreservation of human mesenchymal stem cells using silkworm hemolymph-derived proteins

Kim

Yun

Park

et al. 2016

J Tissue Eng Regen Med

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Cryopreservation methods for human mesenchymal stem cells (hMSCs) typically depend on the presence of fetal bovine serum (FBS) with dimethyl sulphoxide (DMSO), which is not appropriate for therapeutic applications. In our previous study, we found that storage protein 2 (SP2), a natural material derived from silkworm hemolymph, has an inhibitory effect on the generation of reactive oxygen species (ROS). In this study, we used SP2 as an alternative to establish an effective, low-DMSO and FBS-free cryopreservation agent for the cryostorage of hMSCs. We investigated the cell viability and stem cell characterization of umbilical cord-derived MSCs in different freezing media through the freezing and thawing process. We also evaluated the efficacy of cryostorage using these media over 1 week and 1 year. When the cell characteristics (cell viability and stemness) were analysed after thawing, those obtained using 5 mg/ml SP2 were comparable to those obtained using a freezing medium with FBS. The stable cell viability and characteristics were shown even after 1 year of cryopreservation. In addition, when the cells were differentiated into adipocytes and osteocytes, we confirmed that the differentiation behaviours of the thawed cells were well maintained. The positive results could be also obtained when SP2 was applied to other MSCs. The results clearly indicate that SP2 could be used as an alternative to FBS for a freezing medium with reduced DMSO.

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Immune effects of mesenchymal stem cells: Implications for Charcot–Marie–Tooth disease

Cited by 12 publications

References 69 publications

Inflammatory mediators: Parallels between cancer biology and stem cell therapy

Inflammatory mediators: Parallels between cancer biology and stem cell therapy

Inflammation in the Pathogenesis of Inherited Peripheral Neuropathies

Efficient cryopreservation of human mesenchymal stem cells using silkworm hemolymph-derived proteins

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