1978
DOI: 10.1007/bf01642165
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Immune competence in a patient with Hodgkin's disease and relapsing toxoplasmosis

Abstract: A 40 year old woman with Hodgkin's disease twice developed signs of encephalitis while being treated with prednisone and cyclophosphamide for 10 months. Since on both occasions her Toxoplasma dye test titer was 1 : 8000 or higher, she was treated on suspicion of toxoplasmosis with sulfadizine and pyrimethamine. Her tumor therapy was changed to bleomycin with lower doses of prednisone for 12 months. After death from central pontine myelinolysis, Toxoplasma and cytomegalovirus could be isolated, but no lesions a… Show more

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Cited by 24 publications
(5 citation statements)
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“…6 The frequency of acute toxoplasmosis during the present series was the same as reported by us earlier and so, the vast majority had reactivation of latent infection, which is the norm. 19 However, the overall frequency of toxoplasmosis in the present study was a little lower compared to our previous report-9.5% vs. 14%. 6 This drop in frequency could be explained due to cotrimoxazole prophylaxis, which is routinely instituted for the prevention of pneumocystis pneumonia during chemotherapy of paediatric ALL at our centre and majority of the patients in the present study were children.…”
Section: Discussioncontrasting
confidence: 87%
“…6 The frequency of acute toxoplasmosis during the present series was the same as reported by us earlier and so, the vast majority had reactivation of latent infection, which is the norm. 19 However, the overall frequency of toxoplasmosis in the present study was a little lower compared to our previous report-9.5% vs. 14%. 6 This drop in frequency could be explained due to cotrimoxazole prophylaxis, which is routinely instituted for the prevention of pneumocystis pneumonia during chemotherapy of paediatric ALL at our centre and majority of the patients in the present study were children.…”
Section: Discussioncontrasting
confidence: 87%
“…The cancer can also reactivate latent T. gondii infection during antitumor treatment process (Frenkel et al, 1978). A variety of malignancies, including lymphoma, leukemia, and myeloma, can reactivate toxoplasmosis (Maciel et al, 2000; Kojima et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…The neuroimmunopathogenesis should be fully explained at this point. There is evidence that toxoplasmosis can be reactivated in people with certain cancer types, including lymphoma, leukemia, and myeloma [10][11][12]. Organ transplantation also poses a significant risk of toxoplasmosis, which can be fatal.…”
Section: Why Is Toxoplasmic Encephalitis So Important?mentioning
confidence: 99%