2017
DOI: 10.3389/fmicb.2017.00389
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Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Abstract: Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible s… Show more

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Cited by 174 publications
(202 citation statements)
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“…Cancer patients who are seronegative for T. gondii infection could benefit from advice on precautionary measures, to avoid seroconversion that may induce active severe toxoplasmosis [15]. Therefore, potential associations between T. gondii infection and cancer have attracted a lot of attention [3,4,[16][17][18][19][20][21][22][23][24][25][26]. Oral cancer is one of the most common malignant tumours.…”
Section: Introductionmentioning
confidence: 99%
“…Cancer patients who are seronegative for T. gondii infection could benefit from advice on precautionary measures, to avoid seroconversion that may induce active severe toxoplasmosis [15]. Therefore, potential associations between T. gondii infection and cancer have attracted a lot of attention [3,4,[16][17][18][19][20][21][22][23][24][25][26]. Oral cancer is one of the most common malignant tumours.…”
Section: Introductionmentioning
confidence: 99%
“…Toxoplasmosis in immune-competent patients is frequently asymptomatic or presented as flu-like symptoms, but in immune-compromised patients T. gondii leads to a serious fatal infection with multi-organ involvement (15). In the present study all of the recruited patients were immune-competent that explains the mild clinical presentation of acquired toxoplasmosis in the recruited patients.…”
Section: Discussionmentioning
confidence: 49%
“…However, in the fetus and newborns who are congenitally infected, it can cause congenital anomalies such as stillbirth, microcephaly, hydrocephalus, mental retardation, abortion, cerebral calcification in the developing fetus, and fetal death (10). Moreover, in immunosuppressed patients, such as AIDS patients, patients undergoing therapies for malignancies, recipients of solid-organ transplants, and people on hemodialysis, it causes irreversible complications including encephalitis, pneumonia, and disseminated systematic disease (11,12).…”
Section: Introductionmentioning
confidence: 99%