Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals

Yamasaki, Kanji; Takeyoshi, Masahiro; Sawaki, Masakuni; Imatanaka, Nobuya; Shinoda, Kazutoshi; Takatsuki, Mineo

doi:10.1016/s0300-483x(02)00445-6

Cited by 123 publications

(70 citation statements)

References 13 publications

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“…Anti-androgenic activity was demonstrated in systems using cells transfected with three different androgen receptor reporting systems (ARE-luc, MMTV-lacZ, and C3-luc) (Table 56). No consistent effects were observed on male accessory reproductive organ weights in 3 in vivo studies in which rats were dosed with bisphenol A at r600 mg/kg bw/day; the study authors concluded that bisphenol A does not have anti-androgenic or androgenic activity (Kim et al, 2002a;Yamasaki et al, 2003;Nishino et al, 2006). 2.6.5 Genetic toxicity.…”

Section: Summary Of General Toxicology and Biologicmentioning

confidence: 95%

“…Accessory reproductive organs were removed and weighed. Serum luteinizing hormone (LH) and testosterone concentrations were measured by Yamasaki et al (2003) conducted a Hershberger assay in rats exposed to bisphenol A or 1 of 29 other chemicals. In this study, which was conducted according to GLP, animals were housed in stainless steel wire-mesh cages.…”

Section: Androgen Activitymentioning

confidence: 99%

See 1 more Smart Citation

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

401

304

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Section: Summary Of General Toxicology and Biologicmentioning

confidence: 95%

Section: Androgen Activitymentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

401

304

View full text Add to dashboard Cite

“…We selected the immature rat as an experimental model because developing organisms are particularly sensitive to hormone-like chemicals [18].…”

Section: Introductionmentioning

confidence: 99%

Uterotrophic effects of cow milk in immature ovariectomized Sprague–Dawley rats

Zhou

Qin

et al. 2009

Environ Health Prev Med

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Objectives Milk contains considerable quantities of estrogens and progesterone and as such may be one of the risk factors for hormone-related cancers. To determine the hormonal effects of commercial and traditional types of milk, we performed uterotrophic tests. Methods Forty-five rats were ovariectomized and divided into three groups of 15 animals each. The animals were kept for 7 days on powdered chow and one of three different liquids: commercial milk (C), traditional milk (T), or water. At autopsy, wet and dry uterine weights were determined. The cell heights of the uterine epithelium and endometrium were determined. The uterine 5-bromo-2-deoxyuridine (BrdU) labeling index of the epithelium and endometrium gland epithelium was also assessed. Results The weights of wet and dry uterus were 142 ± 13 and 112 ± 10 mg in the C group, 114 ± 30 and 91 ± 24 mg in the T group, and 87 ± 6 and 69 ± 5 mg in the W group. Significant differences in wet and dry uterus weights were found between all pairs of groups. The ratio of the wet uterine weight to body weight was significantly higher in the C and T groups than in the W group. The heights of the uterine epithelium and endometrium were higher and BrdU labeling index was greater in the C group than in the T and W groups. Conclusions Commercially available milk and traditional milk have uterotrophic effects on young ovariectomized rats. Our findings indicate that these uterotrophic effects in the milk groups were partly due to the estrogen and progesterone in the milk.

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“…However, a related compound, diphenylp-phenylenediamine, has been reported to be estrogenic (Yamasaki et al, 2003a).…”

Section: Discussionmentioning

confidence: 99%

“…Among them, NF, a dye, was newly shown as agonistic and antagonistic. BHPMBA (phenolphthalol) (Bitman and Cecil, 1970) and THBP (Yamasaki et al, 2003a) have been reported as estrogenic in the immature rat uterotrophic assay. We found that both chemicals have antagonistic activity, as potent as agonistic effects, i.e.…”

Section: Discussionmentioning

confidence: 99%