NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin, Robert E.; Adams, Jane; Boekelheide, Kim; Gray, L. Earl; Hayward, Simon W.; Lees, Peter S.J.; McIntyre, Barry S.; Portier, Kenneth M.; Schnorr, Teresa M.; Selevan, Sherry G.; Vandenbergh, John G.; Woskie, Susan

doi:10.1002/bdrb.20147

Cited by 398 publications

(307 citation statements)

References 494 publications

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“…With 37% of the HI for anti-androgenic effects already taken up by only three phthalates in the most exposed woman (maximum), there is not much room left for additional exposure to anti-androgens. A growing number of animal and epidemiological studies suggest adverse endocrine-disrupting effects on human health associated with exposure to many of the non-persistent EDCs measured in this study, encompassing effects on growth, reproductive development and thyroid function (Swan et al 2005, Main et al 2006, vom Saal et al 2007, Chapin et al 2008, Wolff et al 2008, Boas et al 2010. In this context, it raises concern that we found detectable levels of phthalate metabolites, parabens and phenols in almost all pregnant women.…”

Section: Discussionmentioning

confidence: 73%

“…in food, plastics including food packaging, fabrics, personal care items, cosmetics and building materials (Golden et al 2005, Chapin et al 2008, Wittassek et al 2011, Jung et al 2012, National Center for Biotechnology Information, www.ncbi.nlm.nih.gov/pmc/articles/PMC2453187/pdf/ ehp0116-a0306a.pdf, last accessed Sep 2013).…”

Section: Introductionmentioning

confidence: 99%

“…BPA is used in polycarbonate and epoxy resins (Chapin et al 2008). Triclosan (TCS), benzophenone-3 (BP-3) (a u.v.-filter) and several other phenols also appear to have endocrine-disrupting activity with adverse effects on, e.g.…”

Section: Introductionmentioning

confidence: 99%

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Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

Renzy-Martin

Frederiksen

Christensen³

et al. 2014

Reproduction

109

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Many phthalates, parabens and phenols are suspected to have endocrine-disrupting properties in humans. They are found in consumer products, including food wrapping, cosmetics and building materials. The foetus is particularly vulnerable and exposure to these chemicals therefore is of concern for pregnant women. We investigated current exposure to several commonly used phthalates, parabens and phenols in healthy, pregnant Danish women. A total of 200 spot urine samples were collected between 8 and 30 weeks of gestation and analysed for metabolites of ten phenols, seven parabens and 16 phthalate by liquid chromatography-tandem mass spectrometry representing 26 non-persistent compounds. The majority of analytes were present in the urine sample collected from most women who participated. Thus, in 174 of the 200 women, metabolites of more than 13 (O50%) of 26 compounds were detected simultaneously. The number of compounds detected per woman (either as the parent compound or its metabolite(s)) ranged from 7 to 21 with a median of 16. The majority of compounds correlated positively with each other within and between chemical groups, suggesting combined exposure sources. Estimated daily intakes (DIs) of phthalates and bisphenol A (BPA) were below their individual tolerable DI (TDI) and with hazard quotients below 1. In conclusion, we found detectable levels of phthalate metabolites, parabens and phenols in almost all pregnant women, suggesting combined multiple exposures. Although the estimated DI of phthalates and BPA for an individual was below TDI, our results still raise concern, as current toxicological risk assessments in humans do not take into account simultaneous exposure. The true cumulative risk for the foetus may therefore be underestimated.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

Renzy-Martin

Frederiksen

Christensen³

et al. 2014

Reproduction

109

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“…14,38 Gestational BPA exposures might affect endocrine or other neurotransmitter pathways and disrupt sexual differentiation of the brain, to alter behavior in a genderdependent manner. 39,40 However, the exposures and behavioral end points used in some animal studies might not be relevant or comparable to human cases.…”

Section: Discussionmentioning

confidence: 99%

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

et al. 2011

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WHAT'S KNOWN ON THIS SUBJECT:Virtually all persons in industrialized countries are exposed to bisphenol A (BPA), and early-life BPA exposure might be associated with behavior problems. Few human studies have been conducted, and the impact of gestational versus childhood BPA exposures is unclear. WHAT THIS STUDY ADDS:BPA exposure during pregnancy, but not childhood, was associated with worse behavior at 3 years of age, especially among girls. Domains related to behavioral and emotional regulation were most affected by gestational BPA exposure. abstract OBJECTIVES:To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. METHODS:We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). RESULTS:BPA was detected in Ͼ97% of the gestational (median: 2.0 g/L) and childhood (median: 4.1 g/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender. CONCLUSIONS:In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear. Pediatrics 2011;128:873-882 AUTHORS:

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“…BPA is described by many researchers as an endocrine disrupting chemical (EDC), however there is much debate and conflicting evidence about its environmental and toxicological impact [Chapin et al, 2008;European Union, 2008;Flint et al, 2012;Molander et al, 2012;Rochester et al, 2013;Bergmann et al, 2013;Teeguarden and Hanson-Drury, 2013;EFSA 2014;Rezg et al, 2014;Tyl et al, 2014;vom Saal and Welshons, 2014]. Many studies have described endocrine disrupting effects across a range of species [Delclos et al, 2014;Hunt et al, 2012;Markey et al, 2003;Newbold et al, 2007].…”

Section: Introductionmentioning

confidence: 99%

A study on temporal trends and estimates of fate of Bisphenol A in agricultural soils after sewage sludge amendment

Zhang

Velly

Rhind

et al. 2015

Science of The Total Environment

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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Cited by 398 publications

References 494 publications

Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

A study on temporal trends and estimates of fate of Bisphenol A in agricultural soils after sewage sludge amendment

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