Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications

Lee, Hao Yuan; Chen, Chyi Liang; Wang, Shi Bo; Su, Lin; Chen, Shu Hung; Liu, Shu Ying; Wu, Tsung‐Han; Lin, Tzou Yien; Chiu, Cheng Hsun

doi:10.1016/j.ijantimicag.2010.12.015

Cited by 50 publications

(54 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Initial treatment with glycopeptides led to the development of heterogeneous glycopeptide resistance, which transformed to full resistance following daptomycin treatment. A similar switch from susceptibility to heteroresistance occurred in A. baumannii infections after prolonged exposure to imipenem (91).…”

Section: Selection For the More Resistant Cells In The Populationmentioning

confidence: 62%

“…Disc diffusion assays (3,14,18,55,(86)(87)(88)(89)(90)(91)(92) and Etest strips have been used to detect heteroresistance as recommended for traditional in vitro susceptibility testing (6,15,18,50,63,64,66,68,71,73,76,80,86,(88)(89)(90)(91)(93)(94)(95)(96)(97)(98)(99)(100)(101). Special Etest strips were developed for glycopeptide resistance detection (GRD Etest) (69,74,75,81,102).…”

Section: Disc Diffusion and Etest Assaysmentioning

confidence: 99%

“…The New Delhi ␤-lactamase (NDM-1) conferred heteroresistance in Providencia rettgeri (134). Similarly, elevated expression of the ␤-lactamase gene in resistant subpopulations compared to native populations was detected in Klebsiella pneumoniae isolates heteroresistant to meropenem (40) and in imipenem-heteroresistant A. baumannii (91). However, certain carbapenem-heteroresistant A. baumannii isolates were carbapenemase negative, suggesting that other factors are involved in the phenomenon (90).…”

Section: Heteroresistance To ␤-Lactamsmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity

2015

View full text Add to dashboard Cite

SUMMARY “Heteroresistance” describes a phenomenon where subpopulations of seemingly isogenic bacteria exhibit a range of susceptibilities to a particular antibiotic. Unfortunately, a lack of standard methods to determine heteroresistance has led to inappropriate use of this term. Heteroresistance has been recognized since at least 1947 and occurs in Gram-positive and Gram-negative bacteria. Its clinical relevance may be considerable, since more resistant subpopulations may be selected during antimicrobial therapy. However, the use of nonstandard methods to define heteroresistance, which are costly and involve considerable labor and resources, precludes evaluating the clinical magnitude and severity of this phenomenon. We review the available literature on antibiotic heteroresistance and propose recommendations for definitions and determination criteria for heteroresistant bacteria. This will help in assessing the global clinical impact of heteroresistance and developing uniform guidelines for improved therapeutic outcomes.

show abstract

Section: Selection For the More Resistant Cells In The Populationmentioning

confidence: 62%

Section: Disc Diffusion and Etest Assaysmentioning

confidence: 99%

Section: Heteroresistance To ␤-Lactamsmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity

2015

View full text Add to dashboard Cite

show abstract

“…[6,7] Additionally, Acinetobacter baummannii could induce drug resistance through plasmid integration, while causing multiple drug resistance plasmids. [8] Gundogan et al [9] found that the resistance of cephalosporins and imipenem against Acinetobacter baummannii was very serious. In our study Acinetobacter baummannii was only sensitive to aminoglycoside antibiotics, quinolone antibiotics and cefoperazone-sulbactam, and the resistance rate of carbapenem reached 72%.…”

Section: Discussionmentioning

confidence: 99%

Distribution and antibiotic resistance of pathogens isolated from ventilator-associated pneumonia patients in pediatric intensive care unit

et al. 2011

View full text Add to dashboard Cite

“…Using differential quantitative proteomic analysis of OMVs from multidrugresistant A. baumannii, Yun et al, reported that carbapenem suppress outer membrane proteins expression and increases the expression of resistance nodulation cell division transporters and protein kinases [146]. Using similar approach, Lee et al, explain the mechanism of hetero-resistance mechanism induced by imipenem in the multi-drug resistant A. baumannii [147]. Biofilm formation is one of the important reasons for the persistence of A. baumannii on the surface of host lung epithelial cells.…”

Section: Significance Of Omv Proteomics In the Study Of Drug Resistanmentioning

confidence: 99%

Significances of OMV and Extracellular Vesicle Proteomics

Tiwari¹

2017

J Data Mining Genomics Proteomics

View full text Add to dashboard Cite

Outer Membrane Vesicle (OMV) proteome has been involved into the pathogenesis of diseases and resistance of microorganisms against a number of antibiotics, mechanism of action of probiotics and host-pathogen interaction etc. We have enlightened the role played by extracellular vesicles proteomics in the pathogenesis of different diseases related to human. Isolation succeeded by purification of ample amount of OMV from biological samples, is one of the most important steps for further proteome related analysis. With the development of both labelled and label-free methods used in proteomics, significant progress has been made in previous years in membrane proteomics. Hence, it is important to review the biological significance of proteins found in the OMV fractions using membrane proteomics approach. We have also explained methods used for isolation, purification and quantification of OMV. In the present review, it can be concluded that proteomic study of outer membrane and extracellular vesicles has now gained priority for the detailed study of disease pathogenesis, drug resistance, vaccine development, cell signalling etc.

show abstract

Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications

Cited by 50 publications

References 32 publications

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity

Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity

Distribution and antibiotic resistance of pathogens isolated from ventilator-associated pneumonia patients in pediatric intensive care unit

Significances of OMV and Extracellular Vesicle Proteomics

Contact Info

Product

Resources

About