Distribution and antibiotic resistance of pathogens isolated from ventilator-associated pneumonia patients in pediatric intensive care unit

Cai, Xiujun; Sun, Jing; Bao, Lei; Li, Wenbin

doi:10.5847/wjem.j.1920-8642.2011.02.007

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Studies also found that the antimicrobial resistance mechanisms were distinct for the Acinetobacter baumannii group. As for resistance to carbapenems, the blaIMP and blaVIM genes belonging to class B metallo-β-lactamase genes were more commonly found in Acinetobacter genospecies 3 and 13TU, whereas the class D carbapenemase genes were observed more often in Acinetobacter baumannii ,[ 26 , 27 ] to which the blaOXA-51 gene was intrinsic. [ 28 ] For genes encoding aminoglycoside-modifying enzymes, Acinetobacter baumannii carried armA and aph(3’)-Ia, whereas Acinetobacter genospecies 13TU possessed aph (3’)-VI.…”

Section: Resultsmentioning

confidence: 99%

TheAcinetobacter baumanniigroup:a systemic review

Zhang

Qiao

2013

World Journal of Emergency Medicine

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BACKGROUND:The Acinetobacter baumannii group, including Acinetobacter baumannii, Acinetobacter genomospecies 3 and 13TU, is phenotypically indistinguishable and uniformly identified as Acinetobacter baumannii by laboratories of clinical microbiology. This review aimed to demonstrate the differences among them.METHODS:Literatures associated with the Acinetobacter baumannii group were identified and selected from PubMed databases and relevant journals.RESULTS:Acinetobacter genospecies 3 and 13TU possess a certain proportion in clinical isolates. There were considerable differences in epidemiologic features, clinical manifestations, antimicrobial resistances and therapeutic options among the Acinetobacter baumannii group. Compared with Acinetobacter genomospecies 3 and 13TU, Acinetobacter baumannii with a higher resistance to antimicrobial agents are easier to be treated inappropriately, and present a worse outcome in patients.CONCLUSION:The Acinetobacter baumannii group comprises three distinct clinical entities, and their clinical value are not equal.

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Section: Resultsmentioning

confidence: 99%

TheAcinetobacter baumanniigroup:a systemic review

Zhang

Qiao

2013

World Journal of Emergency Medicine

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“…MDR A. baumannii was responsible for more than 50% of these infections; over 70% strains were carbapenem-and cephalosporin-resistant. 15 A small prospective Thai study in PICU patients also demonstrated that approximately half of HAIs were due to MDR-GNB organisms, in particular A. baumannii and Pseudomonas spp., all of which were carbapenem-resistant. 16 This study also found stay of more than seven days in PICU to be an independent risk factor for MDR-HAI.…”

mentioning

confidence: 99%

The global threat of antimicrobial resistance - The need for standardized surveillance tools to define burden and develop interventions

Saroey¹,

Berezin²

2015

Jornal de Pediatria

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“…The duration of fever was longer in the pneumonia patients with AMR than those with no AMR, which led to longer hospitalizations in the former ( 4 ). Drug resistances of bacteria isolated from lower respiratory tract aspirations of children with ventilator-associated pneumonia were serious, and the antimicrobial resistance of G - bacilli showed multiple drug resistance ( 5 ). Another study showed that Streptococcus pneumoniae isolates from children with severe community-acquired pneumonia were resistant to many antibiotics ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Temporal development and potential interactions between the gut microbiome and resistome in early childhood

Zhao,

Yang,

Liang

et al. 2024

Microbiol Spectr

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Antimicrobial resistance-associated infections have become a major threat to global health. The gut microbiome serves as a major reservoir of bacteria with antibiotic resistance genes; whereas, the temporal development of gut resistome during early childhood and the factors influencing it remain unclear. Moreover, the potential interactions between gut microbiome and resistome still need to be further explored. In this study, we found that antibiotic treatment led to destabilization of the gut microbiome and resistome structural communities, exhibiting a greater impact on the resistome than on the microbiome. The composition of the gut resistome at various developmental stages was influenced by the abundance and richness of different core microbes. First exposure to antibiotics led to a dramatic increase in the number of opportunistic pathogens carrying multidrug efflux pump encoding genes. Multiple factors could influence the gut microbiome and resistome formation. The data may provide new insights into early-life research. IMPORTANCE In recent years, the irrational or inappropriate use of antibiotics, an important life-saving medical intervention, has led to the emergence and increase of drug-resistant and even multidrug-resistant bacteria. It remains unclear how antibiotic exposure affects various developmental stages of early childhood and how gut core microbes under antibiotic exposure affect the structural composition of the gut resistome. In this study, we focused on early antibiotic exposure and analyzed these questions in detail using samples from infants at various developmental stages. The significance of our research is to elucidate the impact of early antibiotic exposure on the dynamic patterns of the gut resistome in children and to provide new insights for early-life studies.

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Distribution and antibiotic resistance of pathogens isolated from ventilator-associated pneumonia patients in pediatric intensive care unit

Cited by 5 publications

References 11 publications

TheAcinetobacter baumanniigroup:a systemic review

TheAcinetobacter baumanniigroup:a systemic review

The global threat of antimicrobial resistance - The need for standardized surveillance tools to define burden and develop interventions

Temporal development and potential interactions between the gut microbiome and resistome in early childhood

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