Imaging-guided high-efficient photoacoustic tumor therapy with targeting gold nanorods

Zhong, Junping; Wen, Liewei; Yang, Sihua; Xiang, Liangzhong; Chen, Qun; Xing, Da

doi:10.1016/j.nano.2015.04.002

Cited by 71 publications

(42 citation statements)

References 47 publications

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“…[1][2][3][4] To selectively kill tumor cells, targeted GO-ICG is constructed by conjugating integrin v 3 mAb on carboxylated GO (GO-Abs/ICG). Integrin v 3 is overexpressed on U87-MG cell cytomembranes.…”

Section: Resultsmentioning

confidence: 99%

“…Numerous photoacoustic near-infrared probes such as gold nanorods, ICG and carbon nanotubes have been applied in photoacoustic therapy. [1][2][3] However, these probes have some limitations, which limits its wide application in photoacoustic therapy. For instance, the fact that gold nanorods and gold nanoparticles are subjected to laser-induced deformation makes therapy e±ciency fall.…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Yan

Qin

2016

J. Innov. Opt. Health Sci.

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Photoacoustic therapy, using the photoacoustic e®ect of agents for selectively killing tumor cells, has shown promising for treating tumor. Utilization of high optical absorption probes can help to e®ectively improve the photoacoustic therapy e±ciency. Herein, we report a novel highabsorption photoacoustic probe that is composed of indocyanine green (ICG) and graphene oxide (GO), entitled GO-ICG, for photoacoustic therapy. The attached ICG with narrow absorption spectral pro¯le has strong optical absorption in the infrared region. The absorption spectrum of the GO-ICG solution reveals that the GO-ICG particles exhibited a 10-fold higher absorbance at 780 nm (its peak absorbance) as compared with GO. Importantly, ICG's°uorescence is quenched by GO via°uorescence resonance energy transfer. As a result, GO-ICG can high-e±ciently convert the absorbed light energy to acoustic wave under pulsed laser irradiation. We further demonstrate that GO-ICG can produce stronger photoacoustic wave than the GO and ICG alone. Moreover, we conjugate this contrast agent with integrin v 3 mono-clonal antibody to molecularly target the U87-MG human glioblastoma cells for selective tumor cell killing. Finally, our results testify that the photoacoustic therapy e±ciency of GO-ICG is higher than the existing photoacoustic therapy agent. Our work demonstrates that GO-ICG is a high-e±ciency photoacoustic therapy agent. This novel photoacoustic probe is likely to be an available candidate for tumor therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Yan

Qin

2016

J. Innov. Opt. Health Sci.

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“…Other possible applications of PAI include aiding prostate cancer therapy and enabling PAI-guided drug delivery. 62,[101][102][103][104] Real-time PAI can potentially provide helpful insights in the delivery of cancer-treating drugs by monitoring the tumor progression as well as tracking the drug distribution and concentration. 101 Similarly, photonic-based cancer therapies, such as laser induced photodynamic therapy (PDT) 105,106 and photothermal therapy (PTT), 107 can also bene¯t from PAI, as PAI can monitor the drug distribution simultaneously during the therapy without the use of additional contrast agents.…”

Section: Future Outlookmentioning

confidence: 99%

“…62,[101][102][103][104] Real-time PAI can potentially provide helpful insights in the delivery of cancer-treating drugs by monitoring the tumor progression as well as tracking the drug distribution and concentration. 101 Similarly, photonic-based cancer therapies, such as laser induced photodynamic therapy (PDT) 105,106 and photothermal therapy (PTT), 107 can also bene¯t from PAI, as PAI can monitor the drug distribution simultaneously during the therapy without the use of additional contrast agents. Furthermore, PAI can be combined with other imaging modalities, such as°uorescence imaging 81,92,108 and US imaging, 57,58,64,81,109 to provide complementary information and optimal image quality.…”

Section: Future Outlookmentioning

confidence: 99%

Photoacoustic imaging of prostate cancer

Yang

Xiang

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a rapidly growing imaging modality with potential in medical diagnosis and therapy monitoring. This paper focuses on the techniques of prostate PAI and its potential applications in prostate cancer detection. Transurethral light delivery combined with transrectal ultrasound detection overcomes light scattering in the surrounding tissue and provides optimal photoacoustic signals while minimizing invasiveness. While label-free PAI based on endogenous contrast has promising potential for prostate cancer detection, exogenous contrast agents can further enhance the sensitivity and speci¯city of prostate cancer PAI. Further in vivo studies are required in order to achieve the translation of prostate PAI to clinical implementation. The minimal invasiveness, relatively low cost, high speci¯city and sensitivity, and real-time imaging capability are valuable advantages of PAI that may improve the current prostate cancer management in clinic.

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“…Besides this, photoacoustic imaging modality has also been investigated extensively by using various photoacoustic contrast agents comprising dye and nanoparticles to visualize the structure and function of biological tissues for biomedical and biomedicinal applications [15][16][17]. For instance, Zhong et al [16] studied photoacoustic treatment and imaging of human epithelial carcinoma (HeLa) tumor cells in vivo by utilizing contrast therapeutic agents such as single-walled carbon nanotubes, indocyanine green containing nanoparticles (ICG-PL-PEG) and gold nanorods (AuNRs) conjugated with folic acid.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Kakkar

Thomas

Kumi-Barimah

et al. 2017

Journal of Biophotonics

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Instant measurement of elevated biomarkers such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, as well as for monitoring lactic acid level during intense exercise. In the present study, a unique dependence of visible photoluminescence of Eu3+ ions resulting from 5D0 to 7FJ(J = 0,1,2,3,4) transitions, which can be exploited for rapid detection of biomarkers, both in vitro and ex vivo, has been reported. It is observed that the integrated intensity ratio of photoluminescence signals dominating at 591 and 616 nm originating from 5D0 to 7F2 and 5D0 to 7F1 transitions in Eu3+ ions can be used as a biosensing and bioimaging tool for detection of biomarkers released at disease states. The Eu3+ integrated photoluminescence intensity ratio approach reported herein for optical detection of lactates in blood serum, plasma and confocal imaging of brain tissues has very high potential for exploitation of this technique in both in vitro monitoring and in vivo bioimaging applications for the detection of biomarkers in various diseases states.

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Imaging-guided high-efficient photoacoustic tumor therapy with targeting gold nanorods

Cited by 71 publications

References 47 publications

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Photoacoustic imaging of prostate cancer

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

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