Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Yan, Baoyun; Qin, Huan

doi:10.1142/s1793545816420013

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…An indocyanine green modified GO could convert the absorbed light energy with high efficiency to acoustic wave under pulsed laser irradiation. The presented results confirm that the strong laser-induced wave from integrin-targeted indocyanine green-loaded GO could effectively induce U87-MG cell apoptosis thus showed high efficiency in killing tumor cells [125].…”

Section: Targeting Moietiessupporting

confidence: 65%

Nanocomposites as biomolecules delivery agents in nanomedicine

Bamburowicz-Klimkowska

Popławska

Grudziński

2019

J Nanobiotechnol

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Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensions, which are in the same range as those of vital biomolecules, such as antibodies, membrane receptors, nucleic acids, and proteins, allow them to interact with different structures within living organisms. Because of these features, numerous nanoparticles are used in medicine as delivery agents for biomolecules. However, off-target drug delivery can cause serious side effects to normal tissues and organs. Considering this issue, it is essential to develop bioengineering strategies to significantly reduce systemic toxicity and improve therapeutic effect. In contrast to passive delivery, nanosystems enable to obtain enhanced therapeutic efficacy, decrease the possibility of drug resistance, and reduce side effects of “conventional” therapy in cancers. The present review provides an overview of the most recent (mostly last 3 years) achievements related to different biomolecules used to enable targeting capabilities of highly diverse nanoparticles. These include monoclonal antibodies, receptor-specific peptides or proteins, deoxyribonucleic acids, ribonucleic acids, [DNA/RNA] aptamers, and small molecules such as folates, and even vitamins or carbohydrates.

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Section: Targeting Moietiessupporting

confidence: 65%

Nanocomposites as biomolecules delivery agents in nanomedicine

Bamburowicz-Klimkowska

Popławska

Grudziński

2019

J Nanobiotechnol

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“…Since loading efficacy of ICG in modified nano-graphene oxide is markedly higher in comparison with those of PLGA and other ICG encapsulating nanoparticles such as liposome, which is reported to have a low stability and loading capacity below 10% (19,26). Another advantage of nGO is not using toxic metals in its synthesis, which makes it mass production easy and cost-effective in addition to its biocompatibility (20). It is shown that incorporating ICG into nGO increases its photo and physicochemical stability through rich π-π stacking interactions and improves its biocompatibility (19).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it should have optical window (600 -900 nm) for sufficient tissue penetration (18). A good candidate is indocyanine green (ICG) as an amphiphilic dye, also known as CardioGreen®, as the only food and drug administration (FDA)-approved PS (19), with the unique peak absorbance at 780 nm (20,21). Most PSs such as ICG, have limitations such as little photostability and concentration-related aggregation (21,22).…”

Section: Introductionmentioning

confidence: 99%

Improve ICG Based Photodynamic Properties Through Conjugation of ICG Into Nano-Graphene Oxide Against Enterococcus faecalis

Akbari¹,

Pourhajibagher²,

Chiniforush³

et al. 2018

Avicenna J Clin Microbiol Infect

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Background: Nowadays, a new technique such as photodynamic therapy (PDT) is used to achieve effective root canal disinfection and eliminate Enterococcus faecalis as the most prevalent species associated with secondary endodontic infections and treatment failures. Employment of an optimized nontoxic photosensitizer (PS) such as indocyanine green (ICG) is a crucial part of this technique; the current study aimed at improving ICG photodynamic properties through conjugation of ICG into nano-graphene oxide (nGO) as a new PS, to evaluate the antimicrobial effects of nGO/ICG against E. faecalis. Methods:The nGO was synthesized based on the modified Hummer method and then, direct loading of ICG onto its surface. The nGO formation was evaluated using the scanning electron microscope (SEM). The antimicrobial effect of nGO/ICG-PDT against E. faecalis was assessed by counting colony forming units (CFUs). Results and Conclusion:The SEM analysis confirmed successful synthesis of nGO. The nGO/ICG-PDT at an incorporated concentration of 400 µg/mL ICG with irradiation at an energy density of 31.2 J/cm 2 showed significant reduction in the number of E. faecalis higher than PDT based on ICG (1000 µg/mL) (P < 0.05). Since nGO-ICG-PDT showed a significant reduction in the count of E. faecalis at low concentration of ICG (400 µg/mL), it could be proposed as a new approach to treat endodontic infections, alone or in combination with conventional root canal treatment.

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“…In contrast, Yan et al fabricated ICG-loaded GO for the application of PA-based tumor therapy [ 74 ]. The absorption spectrum of GO–ICG showed 10-fold enhanced absorbance compared to pristine GO at its peak region (780 nm) because of ICG’s FL quenching by the resonance energy transfer of GO.…”

Section: Graphene-based Photoacoustic Imagingmentioning

confidence: 99%

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

et al. 2022

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Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research.

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Indocyanine green loaded graphene oxide for high-efficient photoacoustic tumor therapy

Cited by 6 publications

References 21 publications

Nanocomposites as biomolecules delivery agents in nanomedicine

Nanocomposites as biomolecules delivery agents in nanomedicine

Improve ICG Based Photodynamic Properties Through Conjugation of ICG Into Nano-Graphene Oxide Against Enterococcus faecalis

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

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