Imaging Findings in Takayasu's Arteritis

Gotway, Michael B.; Araoz, Philip A.; Macedo, Thanila A.; Stanson, Anthony W.; Higgins, Charles B.; Ring, Ernest J.; Dawn, Samuel K.; Webb, W. Richard; Leung, Jessica; Reddy, Gautham P.

doi:10.2214/ajr.184.6.01841945

Cited by 157 publications

(94 citation statements)

References 8 publications

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“…CT has previously been shown to demonstrate vessel wall alterations in the setting of a normal vessel lumen in the diagnosis and follow-up of patients with early or advanced Takayasu arteritis. 13 In conclusion, the combination of new 320-detector row CTA and PCT may evolve into a novel, noninvasive, fast, and relatively inexpensive method to diagnose early LVCV accurately. In this patient with clinically suspected LVCV, characteristic findings were very useful in evaluating disease severity and monitoring response to treatment.…”

Section: Discussionmentioning

confidence: 96%

Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion

Yahyavi-Firouz-Abadi

Wynn²,

Rybicki³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY:A patient with suspected giant cell arteritis and prior negative findings on superficial temporal artery biopsy was evaluated with 320-detector row CT angiography (CTA) and whole-brain perfusion. Corticosteroid treatment was initiated on the basis of CT angiography findings of arteritis and a cortical perfusion deficit. The patient's symptoms and perfusion imaging findings resolved following therapy. Whole-brain CTA and imaging was helpful in the diagnosis and monitoring this patient with suspected vasculitis. Large vessel cerebral vasculitis (LVCV) represents involvement of the internal carotid artery (ICA); intracranial vertebral arteries; the basilar artery; and the M1, A1, and P1 segments of the middle, anterior, and posterior cerebral arteries (MCA, ACA, and PCA, respectively).1 There is a wide range of diagnostic imaging strategies for patients with clinically suspected LVCV, including multidetector CT (MDCT), MR imaging, positron-emission tomography (PET), and Doppler sonography.2 Three-hundred-twentyϪdetector row CT enables whole-brain perfusion CT (PCT) and quantitative measurements of regional cerebral blood flow and volume (rCBF and rCBV). Such perfusion imaging potentially allows rapid reliable visualization of the effects of cerebral autoregulation mechanisms in parenchymal ischemia.Combined with CT angiography (CTA), PCT has demonstrated clinical utility in acute ischemia.3,4 The major drawback of PCT to date has been the limited volume coverage achieved with 64-section CT imaging.3 The 320 ϫ 0.5 mm detector configuration overcomes this limitation and enables assessment of the entire brain using iodinated contrast opacification for a period of time, so-called "dynamic volume CT." The specific advantage in vasculitis is that abnormalities may not follow vascular distributions, requiring whole-brain PCT to identify all findings. We report a patient who underwent dynamic volume CT before and after treatment for suspected LVCV. Case ReportA 39-year-old right-handed man presented with a left temporal headache, which did not have specific aggregating or relieving factors. The physical examination findings were normal, with the exception of absent reflexes in the right biceps. Pertinent signs included an elevated erythrocyte sedimentation rate (ESR) of 106 mm/h, a C-reactive protein level of 8 mg/L, and a borderline white blood cell count of 11,000 cellsL/ mm 3 . The patient had normal findings on CSF analysis. The medical history was significant for left-sided headaches and a negative prior biopsy of the left superficial temporal artery (STA) for suspected giant cell arteritis (GCA). The differential diagnosis included primary headaches, vasculitis, transient ischemic attack, and impending stroke. Dynamic volume CT (AquilionONE; Toshiba, Tochigi-ken, Japan) was performed during infusion of 70-mL iodinated contrast media (ioversol, Optiray 350; Mallinckrodt, St. Louis, Mo) at 5 mL/s. Single-rotation whole-brain volume datasets were acquired (80 kV, 100 mA, 1-second rotation) intermittently in 2 st...

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Section: Discussionmentioning

confidence: 96%

Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion

Yahyavi-Firouz-Abadi

Wynn²,

Rybicki³

et al. 2009

AJNR Am J Neuroradiol

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“…En éstas la CT y la resonancia magnética (RM) en general muestran engrosamiento de los vasos con realce variable de sus paredes 56 . El PET/CT ha mostrado utilidad para evaluar vasculitis de vasos grandes y medianos, como la enfermedad de Takayasu y arteritis de células gigantes (Figura 9), las que se estiman dan cuenta del 17% de las FOD 13 .…”

Section: Patología Inflamatoria Cardiovascularunclassified

Rol del PET/CT con 18FDG en patología no neoplásica

et al. 2017

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IntroducciónLa tomografía por emisión de positrones/tomografía computada (PET/CT) se ha transformado en una modalidad fundamental en la evaluación oncológica en la práctica clínica actual. En los últimos años se han hecho evidentes nuevas aplicaciones para esta técnica, entre las que se encuentra la evaluación de patologías inflamatorias-infecciosas, las que suelen presentar aumento del metabolismo medible. Esta modalidad consiste en la detección de tejidos metabó-licamente activos mediante la introducción de glucosa marcada, que se acumula en células con mayores tasas de metabolismo. El PET/CT tiene como ventaja el detectar enfermedades incluso cuando éstas aún no presentan un correlato en imágenes morfológicas. Además, la posibilidad de interpretarlas en conjunto

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“…In magnetic resonance (MR) imaging early wall thickening can be depicted as well as mural edema. Both CT and MR show stenosis, mural thrombi, thickening of aortic valves cusp and peripheral effusion [12][13][14].…”

Section: Vasculitismentioning

confidence: 99%

Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease

Chrapko

Stefaniak

et al. 2016

Nucl. Med. Rev.

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This review article discusses the utility of 18F-FDG PET/CT in diagnosis and management of vascular disease. We stress usefulness of this method in large vessel inflammation and infection.In our work we based on the literature analysis and clinical cases diagnosed in our institution by use of 18F-FDG PET/CT. The literature exploration was focusing on vascular inflammation and infections and 18-FDG PET. The search was performed on PubMed database and cross referencing.We present the practical review with several images of vascular diseases like: Takayasu arteritis, giant cell arteritis, vascular graft infections, abdominal aortic aneurysm infections and cases of aortitis and periaortitis. From this work inflammation associated with atheromatic process and vulnerable atherosclerotic plaque we excluded.18F-FGD PET/CT is a sensitive metabolic, reliable, non-invasive imaging modality suitable for diagnosis and follow-up of inflammation and infections in vascular system.

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Imaging Findings in Takayasu's Arteritis

Cited by 157 publications

References 8 publications

Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion

Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion

Rol del PET/CT con 18FDG en patología no neoplásica

Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease

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