Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease

Abstract

This review article discusses the utility of 18F-FDG PET/CT in diagnosis and management of vascular disease. We stress usefulness of this method in large vessel inflammation and infection.In our work we based on the literature analysis and clinical cases diagnosed in our institution by use of 18F-FDG PET/CT. The literature exploration was focusing on vascular inflammation and infections and 18-FDG PET. The search was performed on PubMed database and cross referencing.We present the practical review with several images of vascular diseases like: Takayasu arteritis, giant cell arteritis, vascular graft infections, abdominal aortic aneurysm infections and cases of aortitis and periaortitis. From this work inflammation associated with atheromatic process and vulnerable atherosclerotic plaque we excluded.18F-FGD PET/CT is a sensitive metabolic, reliable, non-invasive imaging modality suitable for diagnosis and follow-up of inflammation and infections in vascular system.

Clinical value of 18F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

“…20,21 In the present study, internal malignancy (oropharyngeal cancer) was detected in one DM patient (case 11) by FDG-PET/CT. 6,22,23 Regarding the ILD, several studies reported the usefulness of FDG-PET/CT for the detection of ILD in DM patients. Therefore, FDG-PET/CT has also been used to investigate inflammatory diseases, such as inflammatory and infectious vascular disease and inflammatory bowel disease.…”

“…Therefore, FDG-PET/CT has also been used to investigate inflammatory diseases, such as inflammatory and infectious vascular disease and inflammatory bowel disease. 6,22,23 Regarding the ILD, several studies reported the usefulness of FDG-PET/CT for the detection of ILD in DM patients. Morita et al 11 reported the usefulness of FDG-PET/CT for the detection of early inflammation in ILD in patients with DM.…”

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“…Although conventional angiography is the standard imaging technique in TA [7]. Recent studies demonstrated that 18F-FDG PET/CT can be helpful in assessment of disease activity before treatment as well as to monitor therapeutic effect or to detect relapse of the disease despite the therapy [8].…”

Management of Aortic Infections: Role of Open Surgery and the Value of Multidisciplinary Team Approach

“…Both 18F-FDG PET/CT and SPECT-CT allow accurate localisation of sites of inflammation, and these investigations are invaluable in the diagnostic workup of AGI, both in the confirmation of AGI (as part of the diagnostic criteria) and in their ability to identify occult non-aortic infection or other causes of inflammation (e.g. vasculitis), thereby preventing unnecessary surgery [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. MRI may have a very limited role [48,49].…”