IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15‐Dependent BMI1 Stability

Zhang, Lixing; Qiang, Jiankun; Yang, Xiaoli; Wang, Dong; Rehman, Adeel; He, Xueyan; Chen, Weilong; Sheng, Dandan; Jiang, Yi; Li, Tao; Du, Ying; Feng, Jing; Hu, Xin; Zhang, Jian; Hu, Xi; Liu, Suling

doi:10.1002/advs.201901728

Cited by 41 publications

(41 citation statements)

References 43 publications

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“…However, there is less information on the association of IL1R2 with IL-1β-dependent intracellular signaling during the pathogenesis of diseases. The increased expression of IL1R2 has been associated with poor prognosis and metastasis of several malignancies [ 23 , 24 ]. The ratio of IL-1β/IL1R2 positively correlated with the production of interferon γ, and negatively correlated with TNF-α production in women with invasive ductal mammary adenocarcinomas [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children

et al. 2020

Ital J Pediatr

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Purpose: Allergic transfusion reactions (ATRs) are immunological reactions after transfusion. Interleukin-1 (IL-1) is a critical regulator for human diseases. We performed this study to investigate the association of type II IL-1 decoy receptor (IL1R2) expression with ATRs in children. Methods: Children received blood transfusions between January and December 2019 were included. The age, sex, number and type of blood transfusion, allergic history, and medical history were collected and statistically analyzed. The blood samples were collected from children with and without ATRs for detecting the relative expression IL1R2 mRNA. Logistics regression analysis was performed to identify the risk factors for ATRs in children. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the predictive performance of risk factors. Results: Totally, 28,840 transfusions in 20,230 children, with 236 ATRs (0.82%) in 117 patients (0.58%) were included. ATRs were common in children at the hematology-oncology department, in children received higher number of blood transfusions, and older children. Platelet concentrate induced a higher incidence of ATRs (3.31%) than red cell concentrate (0.22%, p < 0.0001). After the transfusion, IL1R2 mRNA level was higher in the blood samples in children with ATRs than those without ATRs (p < 0.0001). Logistics regression analysis indicated that platelet concentrate (95% CI 3.555, 293.782) and IL1R2 expression (95% CI 1.171 × 10 2 , 1.494 × 10 4) were independent risk factors for ATRs in children. IL1R2 expression had high performance in predicting ATRs (AUC = 0.998, 100% sensitivity and 98.85% specificity). Conclusion: High IL1R2 expression level in children who received blood transfusions may predict the morbidity of ATR.

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Section: Discussionmentioning

confidence: 99%

Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children

et al. 2020

Ital J Pediatr

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“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is suggested to undergo upregulation in different cancers. BMI1 overexpression ensures tumor sphere formation of cancer cells, and its stability is a positive factor for tumorigenesis [ 104 , 105 ]. MiR-15 as an onco-suppressor factor has been reported to inhibit EMT in BC cells.…”

Section: Micrornas Inhibit Emt In Bladder Cancer Cellsmentioning

confidence: 99%

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

et al. 2020

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Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this life-threatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous non-coding RNAs with 19–24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factor-beta (TGF-β), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse anti-tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics.

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“…IL-1R2 is mainly expressed in neutrophils, B cells, monocytes, and macrophages. Plasma levels of soluble IL-1R2 are between [5][6][7][8][9][10] ng/ml in healthy donors and increase in patients with infectious conditions [7] . IL-1R2 plays a role in a variety of diseases, including chronic skin inflammation, arthritis, endometriosis, and heart transplantation or autoimmune myocarditis [7] .…”

Section: Introductionmentioning

confidence: 99%

IL-1R2 expression in human gastric cancer and its clinical significance

et al. 2021

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Background: Interleukin-1 receptor type II (IL-1R2), also known as CD121b, is a member of the IL-1 receptor family. IL-1R2 acts as negative regulator of the IL-1 system, modulating IL-1 availability for the signaling receptor. IL-1R2 is abnormally expressed in many human inflammatory diseases and cancers, and has important clinical significance. The present study was designed to investigate IL-1R2 expression in human gastric cancer (GC) tissues and the associated clinical implications. Methods: Immunohistochemistry was used to identify the clinical significance and prognostic value of IL-1R2 expression in GC tissues. We investigated IL-1R2 expression in GC tissues, cells, and serum using real-time PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) assays. Results: IL-1R2 was highly expressed in GC tissues, and the overall survival in patients with advanced GC and high IL-1R2 expression was significantly poorer than that in patients with advanced GC and low IL-1R2 expression. Moreover, IL-1R2 mRNA levels in GC tissues and most GC cells were higher than those in para-cancer tissues and GES1 human gastric mucosal epithelial cells. The level of plasma soluble IL-1R2 in GC patients was higher than that of the healthy control group. Conclusion: Increased IL-1R2 levels are involved in the initiation and progression of human GC, and IL-1R2 might be employed to develop immunotherapeutic approaches targeting GC.

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IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15‐Dependent BMI1 Stability

Cited by 41 publications

References 43 publications

Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children

Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

IL-1R2 expression in human gastric cancer and its clinical significance

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