IL-1R2 expression in human gastric cancer and its clinical significance

Yuan, Maoling; Wang, Lei; Huang, Hao; Li, Yuan; Zheng, Xiao; Shao, Qing; Jiang, Jingting

doi:10.1042/bsr20204425

Cited by 11 publications

(10 citation statements)

References 22 publications

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“…We also found, at OSskcm webserver, that lower expression of IL1R2 indicated lower DSS and lower OS when compared with IL1R2 higher expression in patients with cutaneous melanoma, corroborating with our results. The association of IL1R2 expression and patient's survival was recently described in breast and gastric cancer [28,29]. Unlike our results in cutaneous melanoma, patients with breast or gastric cancer with higher IL1R2 expression presented worst prognosis when compared with lower expression patients [28,29].…”

Section: Discussioncontrasting

confidence: 78%

Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma

et al. 2021

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Cutaneous melanoma is the most aggressive skin cancer with high mortality. Proinflammatory cytokines can modulate the proliferation and survival of cutaneous melanoma cells. Higher levels of interleukin-1β (IL1B) were associated with tumor cell proliferation, invasion, and migration, and the IL-1 type II receptor (IL1R2) serves as an endogenous inhibitor of IL1B signaling. Single-nucleotide variations (SNVs) in these genes (IL1B rs16944 and IL1R2 rs4141134) can modulate cytokine production and binding; however, their role in cutaneous melanoma is still unknown. Thus, we investigated the influence of the above SNVs in clinicopathological aspects and cutaneous melanoma patients' survival.In the present study, we analyzed 193 patients with cutaneous melanoma for IL1B c.-598T>C (rs16944) and IL1R2 c.-2009G>A (rs4141134) genotypes with TaqMan assays. Differences between groups were calculated using χ 2 or Fisher's exact test and multiple logistic regression. Progression-free survival (PFS) and melanoma-specific survival were calculated by Kaplan-Meier and Cox methods. The prognostic value of IL1R2 was also analyzed by the online consensus survival webserver for skin cutaneous melanoma (OSskcm). We found that IL1R2 rs4141134 GG genotype was more common in patients with nodular subtype (49.1% vs. 29.8%, P = 0.01) and the frequency of IL1R2 rs4141134 GG or GA was higher in patients with Clark levels III-V (87.4% vs. 75.8%, P = 0.04). Patients with IL1R2 rs4141134 GG or GA genotypes presented lower PFS (hazard ratio: 3.12, 95% confidence interval, 1.10-8.79, P = 0.03) when compared with AA genotype, supported by OSskcm results. Thus, our study presented for the first time preliminary evidence that IL1R2 rs4141134 SNV may modulate cutaneous melanoma clinicopathological aspects and survival possible by allowing IL1B signaling.

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Section: Discussioncontrasting

confidence: 78%

Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma

et al. 2021

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“…Furthermore, IL1R2 is found to be highly expressed in gastric cancer tissues. 11 Interleukin-1 receptor type II, activated by IL-1β, is upregulated in breast cancer tissues and especially in breast tumor-initiating cells. 12 …”

Section: Introductionmentioning

confidence: 99%

Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance

Chen¹,

Li²,

Wang³

et al. 2022

The Anatolian Journal of Cardiology

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Background: IL-1 has been widely explored and played a role in regulating inflammatory and immune responses to various disorders. Nevertheless, the role of interleukin-1 receptor type II, a protein-coding gene of interleukin-1 in coronary artery disease patients with peripheral blood mononuclear cells, persists to be undetermined. Methods: Our study discovered the IL-1 receptor type II expression through gene expression omnibus (GEO) public repository based on bioinformatics tools and further validation was carried out between coronary artery disease patients and healthy participants using peripheral blood mononuclear cells samples in Second Hospital of Tianjin Medical University. A total of 180 participants, comprising 90 cases of coronary artery disease and 90 samples of healthy control were retrospectively evaluated and the correlation of IL-1 receptor type II was observed between serum levels of oxidized low-density lipoprotein and SYNTAX score. Furthermore, the clinical significance of IL-1 receptor type II was evaluated in peripheral blood mononuclear cells of coronary artery disease patients by the receiver operating curve using the area under the curve. Results: IL-1 receptor type II was markedly overexpressed in peripheral blood mononuclear cells and severe patients with coronary artery disease compared to the healthy control participants. Meanwhile, a positive correlation of IL-1 receptor type II expression was significantly observed between SYNTAX score and oxidized low-density lipoprotein of coronary artery disease patients. Further, the receiver operating curve achieved a significantly higher area under the curve of 0.813 in coronary artery disease patients with peripheral blood mononuclear cells. Thus, IL-1 receptor type II expressions were not only directly correlated with peripheral blood mononuclear cells but also showed potential significance in coronary artery disease patients. Conclusion: IL-1 receptor type II might be involved in the immune/inflammatory responses of coronary artery disease accompanied by other cytokine receptor genes.

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“…PTAFR is high expressed in cervical cancer samples when compared with normal cervical tissue, which protect tumor cells from radiation-induced cell death ( da Silva-Junior et al, 2018 ). Increased levels of IL1R2 are involved in the initiation and progression of human gastric cancer, and IL1R2 might be an immunotherapeutic target ( Yuan et al, 2021 ). It could be speculated that both PTAFR and IL1R2 would play important roles in liver cancer.…”

Section: Discussionmentioning

confidence: 99%

PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell

Zheng

Fan

Zhang

et al. 2023

PeerJ

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Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 has also been reported to be a marker of increased invasive potential of liver cancer. However, the roles and underlying molecular mechanism of PAIP1 in liver cancer is still unclear. Here, cell viability and the gene expression profile of liver cancer line HepG2 transfected with PAIP1 siRNA was compared with cells transfected with non-targeting control siRNA. The results showed that PAIP1 knockdown inhibited cell viability, and extensively affects expression of 893 genes at transcriptional level in HepG2 cells. Gene function analysis showed that a large number of PAIP1 up-regulated genes were enriched in term of DNA-dependent transcription and the down-regulated genes were enriched in some pathways including immune response and inflammatory response. qPCR confirmed that PAIP1 knockdown positively regulated the expression of selected immune and inflammatory factor genes in HepG2 cells. Expression analysis of TCGA revealed that PAIP1 had positive correlations with two immune associated genes IL1R2 and PTAFR in liver tumor tissue. Taken together, our results demonstrated that PAIP1 was not only a translation regulator, but also a transcription regulator in liver cancer. Moreover, PAIP1 could function as a regulatory factor of immune and inflammatory genes in liver cancer. Thus, our study provides important cues for further study on the regulatory mechanism of PAIP1 in liver cancer.

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IL-1R2 expression in human gastric cancer and its clinical significance

Cited by 11 publications

References 22 publications

Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma

Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma

Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance

PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell

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