Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

Ashrafizadeh, Milad; Hushmandi, Kiavash; Hashemi, Mehrdad; Akbari, Mohammad Esmaeil; Kubatka, Peter; Raei, Mehdi; Koklesová, Lenka; Shahinozzaman, Muhammad; Mohammadinejad, Reza; Najafi, Masoud; Sethi, Gautam; Kumar, Alan Prem; Zarrabi, Ali

doi:10.3390/biom10081159

Cited by 90 publications

(53 citation statements)

References 241 publications

(227 reference statements)

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“…MiRNAs are upstream mediators of a variety of molecular pathways due to their role in coordinating detailed biological mechanisms [128][129][130][131][132][133][134][135]. As occurs in different pathological events, miRNA dysregulation leads to alterations in normal cellular events [136,137].…”

Section: Nrf2 Modulationmentioning

confidence: 99%

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

et al. 2021

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Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to chemoresistance. Due to dose-dependent toxicity, high concentrations of DOX cannot be administered to cancer patients. Therefore, experiments have been directed towards revealing underlying mechanisms responsible for DOX resistance and ameliorating its adverse effects. Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling is activated to increase levels of reactive oxygen species (ROS) in cells to protect them against oxidative stress. It has been reported that Nrf2 activation is associated with drug resistance. In cells exposed to DOX, stimulation of Nrf2 signaling protects cells against cell death. Various upstream mediators regulate Nrf2 in DOX resistance. Strategies, both pharmacological and genetic interventions, have been applied for reversing DOX resistance. However, Nrf2 induction is of importance for alleviating side effects of DOX. Pharmacological agents with naturally occurring compounds as the most common have been used for inducing Nrf2 signaling in DOX amelioration. Furthermore, signaling networks in which Nrf2 is a key player for protection against DOX adverse effects have been revealed and are discussed in the current review.

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Section: Nrf2 Modulationmentioning

confidence: 99%

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

et al. 2021

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“…Since its identification in 1993 as small RNA molecule in Caenorhabditis elegans , it has been extensively studied and well-characterized over the past decades [ 18 ]. miRNAs are known to regulate various biological processes, such as proliferation, differentiation, apoptosis, immune response, and maintenance of homeostasis [ 19 , 20 , 21 , 22 , 23 ]. These small dynamic RNA molecules regulate gene expression by binding to the 3′-untranslated regions (3′-UTR) of target mRNAs, leading to post-transcriptional inactivation of the target gene, either by mRNA degradation or inhibiting translation [ 24 ] Due to its variability in the binding region and imperfect complementary binding, a single miRNA can bind and target multiple mRNAs [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review

Rishabh

Khadilkar

Kumar

et al. 2021

IJMS

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Oral cancers constitute the majority of head and neck tumors, with a relatively high incidence and poor survival rate in developing countries. While the five-year survival rates of the oral cancer patients have increased to 65%, the overall survival for advanced stages has been at 27% for the past ten years, emphasizing the necessity for further understanding the etiology of the disease, diagnosis, and formulating possible novel treatment regimens. MicroRNAs (miRNAs), a family of small non-coding RNA, have emerged as master modulators of gene expression in various cellular and biological process. Aberrant expression of these dynamic molecules has been associated with many human diseases, including oral cancers. The deregulated miRNAs have been shown to control various oncogenic processes, including sustaining proliferative signaling, evading growth suppressors, resisting cell death activating invasion and metastasis, and inducing angiogenesis. Hence, the aberrant expression of miRNAs associated with oral cancers, makes them potential candidates for the investigation of functional markers, which will aid in the differential diagnosis, prognosis, and development of novel therapeutic regimens. This review presents a holistic insight into our understanding of the role of miRNAs in regulating various hallmarks of oral tumorigenesis.

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“… 16 The epithelial cell surface markers include the most well-known factor E-cadherin, occluding and claudins, while the mesenchymal cell surface markers are comprised of N-cadherin, fibronectin as well as Vimentin. 17 We observed by RT-qPCR that circ_0000629 restored E-cadherin expression, whereas decreased expression patterns of Vimentin, Snail and N-cadherin. However, the underlying mechanism is undetermined.…”

Section: Discussionmentioning

confidence: 75%

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

Wang

Luo

et al. 2021

CMAR

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Background Recent studies showed circular RNAs (circRNAs) played regulatory roles in bladder cancer (BC). However, the relevance of circ_0000629, a newly identified circRNA, has not been determined yet. We aimed to characterize the function of circ_0000629 in BC and the relevant mechanism. Methods First, we downloaded circRNA-related microarrays GSE147985 and GSE92675 from the GEO database, followed by a validation in our clinically obtained samples. We then overexpressed circ_0000629 in T24 and SW780 cells and evaluated the effects of circ_0000629 on BC cell proliferatory, apoptotic, and metastatic abilities. We further detected the subcellular localization of circ_0000629 in T24 and SW780 cells by the fractionation and export assay and FISH experiments. Integrated microarray analyses and bioinformatics website prediction were utilized to screen out the downstream microRNA (miRNA)/mRNA. The effects of miR-1290 and CDC73 on BC cell growth and metastasis was verified by functional rescue experiments. In addition, mice xenografts were built to measure the effect of circ_0000629 on tumor growth in vivo. Results Circ_0000629 and CDC73 were reduced, and miR-1290 was significantly overexpressed in BC tissues and cells. Moreover, circ_0000629 significantly inhibited the development and metastasis of BC cells, but further overexpression of miR-1290 or knockdown of CDC73 attenuated the inhibitory effect of circ_0000629 on BC cells. Circ_0000629 localized in the cytoplasm and regulated CDC73 expression by sponging miR-1290. Further, overexpressed circ_0000629 reduced the BC tumor growth in vivo. Conclusion Circ_0000629 promotes the expression of CDC73 by competitively binding to miR-1290, thereby inhibiting the growth and metastasis of BC cells.

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Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

Cited by 90 publications

References 241 publications

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

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