IL10 −1082, IL10 −819 and IL10 −592 polymorphisms are associated with chronic periodontitis in a Macedonian population

Atanasovska-Stojanovska, Aneta; Trajkov, Dejan; Поповска, Мирјана; Спироски, Мирко

doi:10.1016/j.humimm.2012.04.009

Cited by 18 publications

(35 citation statements)

References 45 publications

(61 reference statements)

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“…Our findings were in accordance with the results from Asian and mixed populations (Claudino et al, ; Hu et al, ), which showed no significant association. Similarly, Atanasovska‐Stojanovska and colleagues reported no significant association between ‐592 (C/A) alleles and genotypes with the susceptibility to periodontitis in a Macedonian population (Atanasovska‐Stojanovska, Trajkov, Popovska, & Spiroski, ). Moudi and co‐workers showed no significant association between allele and genotype frequencies of IL‐10 ‐592 (C/A) and chronic periodontitis in a recent study in Zahedan, southeast of Iran, which was in accordance with our findings (Moudi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

et al. 2019

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Objective Periodontitis is an inflammatory disease that is a result of the interaction between pathogenic bacteria and host immune response. Genetic alterations in interleukin‐10 (IL‐10) gene may be associated with the increased risk of periodontitis. We investigated the association between genotype and haplotype frequencies of IL‐10 gene polymorphisms and susceptibility to periodontitis in an Iranian population. Methods In this case–control study, a total of 64 patients with periodontitis and 128 healthy subjects were recruited. The PCR‐RFLP technique was used to detect IL‐10 promoter genotypes at the positions of ‐1082 (G/A), ‐819 (C/T), and ‐592 (C/A) in association with the susceptibility to severe chronic periodontitis. Results Regarding IL‐10 ‐592 (C/A) and IL‐10 ‐819 (C/T) alleles and genotypes, no significant association was observed between the risk of periodontitis and genotype frequencies. However, the frequency of GG genotype in IL‐10 ‐1082 (G/A) polymorphic region was higher in normal subjects and was associated with the decreased risk of periodontitis under recessive model [OR = 2.89, 95% CI (0.99–8.43), p = 0.039]. Haplotype analysis revealed a significantly higher presence of H7 (AGC; ‐592/‐1082/‐819) [OR = 97.74, 95% CI (95.52–99.96), p < 0.0001]. Conclusion IL‐10 ‐1082(G/A) polymorphism and AGC (‐592/‐1082/‐819) haplotype could be associated with the susceptibility to chronic periodontitis.

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Section: Discussionmentioning

confidence: 99%

Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

et al. 2019

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“…The haplotype ATA of IL-10, as a “low interleukin-10 producer,” was proved as a risk indicator for generalized aggressive periodontitis [56]. Moreover, others observed that these single-nucleotide polymorphisms (SNPs) of IL-10, including −1082(−1087)A/G, −819(−824)C/T and −592(−597)C/A, were associated with the generalized chronic periodontitis and/or aggressive periodontitis [57–60], which elucidates the role of IL-10 in periodontal diseases.…”

Section: Il-10 In Periodontal Diseases and Periodontal Treatmentmentioning

confidence: 99%

Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

Zhang

Chen

Yan

et al. 2014

BioMed Research International

140

120

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Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a significant impact on millions of people with the risk of tooth loss and bone fracture. The integrity and strength of bone are maintained through the balance between bone resorption and bone formation by osteoclasts and osteoblasts, respectively, so the loss of bone results from the disruption of such balance due to increased resorption or/and decreased formation of bone. The goal of therapies for diseases of bone loss is to reduce bone loss, improve bone formation, and then keep healthy bone density. Current therapies have mostly relied on long-term medication, exercise, anti-inflammatory therapies, and changing of the life style. However there are some limitations for some patients in the effective treatments for bone loss diseases because of the complexity of bone loss. Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine, and recent studies have indicated that IL-10 can contribute to the maintenance of bone mass through inhibition of osteoclastic bone resorption and regulation of osteoblastic bone formation. This paper will provide a brief overview of the role of IL-10 in bone loss diseases and discuss the possibility of IL-10 adoption in therapy of bone loss diseases therapy.

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“…IL-10, an anti-inflammatory cytokine, plays a role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines such as IL-1, -2, -6 and stimulating protective antibody production (15). The gene encoding for IL-10 is mapped on chromosome one (1q31-32) (16). A large number of single nucleotide polymorphisms have been identified in the IL-10 gene promoter (17).…”

Section: Introductionmentioning

confidence: 99%

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

Toker¹,

Görgün²,

Korkmaz³

2017

Cent Eur J Public Health

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SUMMARYObjective: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis.Methods: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p = 0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR = 9.93, 95% CI: 2.11-46.7, OR = 5.7, 95% CI: 1.22-26.89, respectively).Conclusions: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/ aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis.Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.

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IL10 −1082, IL10 −819 and IL10 −592 polymorphisms are associated with chronic periodontitis in a Macedonian population

Cited by 18 publications

References 45 publications

Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis

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