Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

Emampanahi, Mohaddeseh; Rad, Saba Masoudi; Jazi, Marie Saghaeian; Samaei, Nader Mansour; Behnampour, Nasser; Mohammadi, Saeed; Fakhari, Elham

doi:10.1111/odi.13114

Cited by 12 publications

(10 citation statements)

References 38 publications

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“…The study revealed a protective role of the G allele against CPO. Almost similar results were obtained by Emampanahi et al [21] in the same population. Several other Asian studies [22][23][24][25] also indicated such a role of the G allele of IL-10-1082 G/A polymorphism against CPO.…”

Section: Discussionsupporting

confidence: 89%

“…Several other Asian studies [22][23][24][25] also indicated such a role of the G allele of IL-10-1082 G/A polymorphism against CPO. Emampanahi et al [21] revealed that the AGC haplotype (-592/-1082/-819) haplotype was higher in healthy subjects, while AAC (-592/-1082/-819) was markedly higher among patients with CPO. The protective mechanism of the G-allele and its associated genotypes is related to the position of this polymorphism in the promoter region of the gene.…”

Section: Discussionmentioning

confidence: 99%

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Interleukin 10 Gene Promoter Polymorphisms in Patients with Chronic Periodontitis

,¹,

Atrooz²,

Hasan³

2022

DJM

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Background: The anti-inflammatory cytokine, interleukin 10 (IL 10), has a crucial role in periodontal diseases. The gene coding for this cytokine is pleomorphic. In the promoter region of the IL 10 gene, two single nucleotide polymorphisms (SNPs), IL10 1082 and IL 819, have been discovered to affect IL 10 expressions. Objective: To investigate the association of two single nucleotide polymorphisms in the interleukin 10 gene (IL-10-1082 G/A and IL-10-819 C/T) with CPO. Patients and Methods: A total of 64 patients with chronic periodontitis (CPO) and another 40 apparently healthy individuals were enrolled in this case-control study. The IL-10 gene was amplified with two specific sets of primers. Genotyping was achieved by allele-specific polymerase chain reaction (AS-PCR). Results: The frequency of GG, GA and AA genotypes of the SNP IL-10-1082G/A among patients was 48.44%, 42.19% and 9.37% respectively, compared with 32.5%, 35% and 32.5% respectively, among controls. Logistic regression test revealed a significant difference in the frequency of AG (OR=0.19, 95%CI=0.06-0.62, P=0.006) and GG genotype (OR= 0.24, 95%CI=0.07-0.77, p=0.016) between patients and controls. Furthermore, the haplotype block GC (G allele of IL-10-1082G/A and C allele of IL-10-819 C/T) was more common in controls than patients (36.25% vs. 33.44%) with a significant difference (OR= 0.54, 95%CI= 0.29-0.99, p= 0.048). Conclusion: These data suggest that the IL-10-1082 G/A gene polymorphism could be a risk factor for CPO in Iraqi patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Interleukin 10 Gene Promoter Polymorphisms in Patients with Chronic Periodontitis

,¹,

Atrooz²,

Hasan³

2022

DJM

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“…They participate in systemic inflammation and play vital roles in innate and adaptive immunity. Previous studies had indicated that IL gene SNPs associate with the development of both bacteria-and virus-related inflammatory disorders, such as sepsis [9,10], periodontitis [11,12], hepatitis B [13], and C [14] virus infections. However, current studies were still limited regarding the potential associations between IL gene SNPs and the risks of developing PTOM, especially in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

Jiang

et al. 2020

Mediators of Inflammation

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This case-control study aimed to investigate potential associations between interleukin (IL) gene polymorphisms and the risks of developing extremity posttraumatic osteomyelitis (PTOM) in Chinese Han population. Altogether, 189 PTOM patients and 200 healthy controls were genotyped of IL-1α (rs17561, rs1800587), IL-1β (rs16944, rs1143627, rs1143634, rs2853550), IL-1RN (rs4251961, rs419598, rs315951), IL-4 (rs2243248, rs2243250), IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227307), IL-10 (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), IL-17A (rs2275913), and IL-17F (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 (P=0.049) and rs4251961 (P=0.007) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (OR=1.854, P=0.017), homozygous (OR=1.831, P=0.041), and heterozygous (OR=1.869, P=0.022) models, and of rs1143627 by dominant (OR=1.735, P=0.032) and homozygous (OR=1.839, P=0.040) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (OR=0.446, P=0.005) and heterozygous (OR=0.409, P=0.003) models, and of rs1800796 by dominant (OR=4.184, P=0.029), homozygous (OR=4.378, P=0.026), and heterozygous (OR=3.834, P=0.046) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.

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“…A few IL-10 promoter polymorphic sites have been characterized with determination of three polymorphisms from transcription initiation site at positions -819 (rs1800871), -592 (rs1800872) and -1082 (rs1800896) (-1082) (46). These IL-10 promoter polymorphisms have been the most widely investigated in various diseases: asthma, cardiovascular diseases, diabetic nephropathy, systemic lupus erythematosus, rheumatoid arthritis, chronic periodontitis, Alzheimer's disease (47)(48)(49)(50)(51)(52)(53). Furthermore, these polymorphisms are strongly associated with various serum levels of IL-10 in vivo (54).…”

Section: Snp Selectionmentioning

confidence: 99%

Impact ofIL-10Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

Pašvenskaitė

Liutkevičienė

Gedvilaitė

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate. Patients and Methods: A total of 300 LSCC patients and 533 controls were included in the study. Genotyping was carried out using RT-PCR; IL-10 serum levels were analyzed by ELISA. Results: Significant associations were identified between IL-10 rs1800871 variants and advanced stage of LSCC patient group in the codominant, recessive and additive models (OR=0. 473, p=0.027; OR=0.510, p=0.040; and OR=0.733; p=0.037). Significant variants of IL-10 rs1800872 were determined in the codominant, recessive and additive models (OR=0. 473, p=0.027; OR=0.510, p=0.040; and OR=0.733, p=0.037). The distribution of IL-10 SNPs genotypes did not impact LSCC patient survival rate (respectively, p=0.952; p=0.952; p=0.991). Conclusion: IL-10:rs1800871 and rs1800872 SNPs are associated with advanced stage of LSCC. The genotypic distribution of IL-10 SNPs does not influence the survival rate of LSCC patients.Laryngeal squamous cell carcinoma (LSCC) represents the largest subgroup of head and neck squamous cell carcinoma (HNSCC) and is one of the most common tumors in the respiratory system (1). In all respiratory tract malignancies, LSCC ranks second in terms of the mortality rate (2). LSCC is more commonly diagnosed in men than women (3). According to Global Cancer Observatory data, 154,977 new male and 22,445 female cases were registered in 2018, demonstrating almost seven-times higher incidence in the male population (4). According to racial disparities, younger age African Americans have a higher incidence and mortality compared to Caucasians (1). Furthermore, race is a prognostic factor for 5-year overall survival for white, black, Hispanic, and Asian patients; 60.6%, 52.7%, 59.5% and, 65.7%, respectively (5). Sophisticated diagnostics tools (video laryngostroboscopy, flexible endoscopy, contact endoscopy), surgical (endolaryngeal laser approach, partial laryngectomy, total laryngectomy) and/or nonsurgical options (advanced radiotherapy and/or chemotherapy) and multidisciplinary team-based decision making are used to choose the most suitable treatment modality for LSCC. However, LSCC patient survival rate of 1-, 3-, 5-, and 10-years have not significantly improved and remain relatively low: 81%, 62%, 53%, and 38%, respectively (6). The low survival rate, especially at advanced stages, might be due to little worrying symptoms such as hoarseness, which delay the diagnosis of LSCC and allow progression of the disease resulting in laryngeal stenosis with dyspnoea and stridor. Also, a lack of screening programs (endoscopic laryngeal examination performed by an otorhino...

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Association between interleukin‐10 gene polymorphisms and severe chronic periodontitis

Cited by 12 publications

References 38 publications

Interleukin 10 Gene Promoter Polymorphisms in Patients with Chronic Periodontitis

Interleukin 10 Gene Promoter Polymorphisms in Patients with Chronic Periodontitis

Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

Impact ofIL-10Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

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