“…MSCs can be used to suppress the development of HCC. Their multipotency, immunoregulatory, pro-regenerative effects (Hsu et al, 2017) and their chemotactic properties to home to tumor invaded regions make them a good candidate for cancer therapy (Bayo et al, 2017). MSCs inhibit tumor growth by increasing inflammatory infiltration (Ohlsson et al, 2003), inhibiting angiogenesis (Otsu et al, 2009), suppressing the signaling of Wnt (Qiao et al, 2008a;Qiao et al, 2008b) and AKT (Khakoo et al, 2006), and inducing cell cycle arrest and apoptosis 4 (Cousin et al, 2009;Dasari et al, 2010;Lu et al, 2008).…”