Novel Combination of Mesenchymal Stem Cell-Conditioned Medium with Sorafenib Have Synergistic Antitumor Effect of Hepatocellular Carcinoma Cells

Seyhoun, Iman; Hajighasemlou, Saieh; Ai, Jafar; Hosseinzadeh, Faezeh; Mirmoghtadaei, Milad; Seyhoun, Seyed Moein; Parseh, Benyamin; Abdolahi, Shahrokh; Ghazvinian, Zeinab; Shadnoush, Mahdi

doi:10.31557/apjcp.2019.20.1.263

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…Meaningfully, the synergistic effect of sorafenib and 80% MSCs-CM in HCC cells is of clinical significance, allowing the use of lower doses of sorafenib and being more effective than currently single use. 33 More precise drug-resistant targets have already arisen. For example, GRP78, overexpressed in sorafenib-resistant liver cancer cells, is used as a therapeutic target of siGRP78-modified MSCs exosomes combined with sorafenib in HCC cells, thereby weakening the growth and invasion of cancer cells in vivo and in vitro, reversing sorafenib resistance.…”

Section: Mscs and Sorafenibmentioning

confidence: 99%

The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma

Zhang

Zhu

et al. 2022

Cancer Medicine

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Primary liver cancer is the seventh most common cancer and the second most common cause of cancer death in the world. 1 Globally, hepatocellular carcinoma (HCC) is the main histological type of liver cancer, accounting for more than 75% of the total number of liver cancers. 2 Liver cancer stem cells (LCSCs), recognized by certain surface markers, are responsible for the tumorigenesis, recurrence, metastasis, chemotherapy resistance and poor prognosis of HCC. 3 Increasing evidence supports the great effects of the tumor microenvironment (TME) on the generation, development and metastasis of HCC. TME is composed of diversified cells and non-cellular components. 4 Mesenchymal stem cells (MSCs), an integral part of TME, are considered to be a key factor in tumor progression and metastasis. MSCs are also referred to as "mesenchymal stromal cells", which can further be induced to differentiate into osteoblasts, chondrocytes, adipocytes, and other cells in vitro. 5 Recently, massive research has been devoted to exploring the association between HCC and MSCs. The function of

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Section: Mscs and Sorafenibmentioning

confidence: 99%

The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma

Zhang

Zhu

et al. 2022

Cancer Medicine

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“…The MSCs secrete a number of paracrine factors, cytokines, and vascular endothelial growth factor (VEGF), which may influence the proliferation and viability of cancer cells. In this regard, MSCs secretome may affect tumor cells and inhibit their development (19). The hWJSCs have been used as an anticancer agent in many previous studies (20,21).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Cervical Cancer Cell Line Hela by Human Wharton’s Jelly Stem Cells Through Induction of Apoptosis

Ghorbani

Maleki

2020

Gene Cell Tissue

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Background: Cervical cancer is one of the most common cancers of women in the world, which causes high mortality. The human umbilical cord Wharton's jelly stem cells (hWJSCs) can inhibit various cancer cells. Objectives: This study aimed to investigate the effects of conditioned medium and cellular extract of human umbilical cord hWJSCs on cervical cancer cell line, Hela. Methods: After isolation and primary culture of hWJSCs, conditioned medium and cellular extracts of hWJSCs were prepared, and its anti-proliferative effects were evaluated on cervical cancer cells, Hela using micro-culture tetrazolium (MTT) assay. After total RNA extraction and cDNA synthesis, expression of apoptosis-related BCL-2 and BAX genes were evaluated using real-time PCR. Results: The results showed that conditioned medium (55% concentration in 72 hours) and cellular extraction (10% concentration in 24 hours) caused death of 50% cancer cells (IC50). The anti-cancer effects of conditioned medium and cellular extraction were concentration-and time-dependent. The conditioned medium and cellular extract of hWJSCs significantly down-regulated and upregulated mRNA expression of apoptosis-related BCL-2 and BAX genes, respectively. Conclusions: Our study showed that conditioned medium and cellular extract of human umbilical cord hWJSCs inhibit viability and proliferation of cervical cancer cells. However, further studies on animal models are necessary for more accurate results.

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“…Seyhoun et al were able to demonstrate that co-treatment with sorafenib alongside MSC CM was able to enhance the cytotoxic effects of sorafenib on HepG2 cell lines [ 169 ]. The combination of sorafenib with MSCs showed a similar result, which included the inhibition of hepatocellular carcinoma growth in a mouse model [ 170 ].…”

Section: Antitumor Properties Of Mesenchymal Stromal Cell Derived Ext...mentioning

confidence: 99%

The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis

Gilazieva

Ponomarev

Rizvanov

et al. 2022

Biology

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Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play an important role in tumor progression. MSCs remodel the extracellular matrix, participate in the epithelial–mesenchymal transition, promote the spread of metastases, and inhibit antitumor immune responses in the TME; however, there are also data pertaining to the antitumor effects of MSCs. MSCs activate the cell death mechanism by modulating the expression of proteins involved in the regulation of the cell cycle, angiogenesis receptors, and proapoptotic proteins. One of the main ways in which MSCs and TME interact is through the production of extracellular vesicles (EVs) by cells. Currently, data on the effects of both MSCs and their EVs on tumor cells are rather contradictory. Various studies have reported that EVs from MSCs can have either antitumor or pro-tumor effects, depending on both the tumor type and developmental stage. In this review, we discuss published data on EV MSCs and their effect on tumor cells. The molecular composition of vesicles obtained from MSCs is also presented in the review. In addition, the use of EV MSCs for the development of new methods for treating oncological diseases is described.

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Novel Combination of Mesenchymal Stem Cell-Conditioned Medium with Sorafenib Have Synergistic Antitumor Effect of Hepatocellular Carcinoma Cells

Cited by 12 publications

References 29 publications

The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma

The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma

Inhibition of Cervical Cancer Cell Line Hela by Human Wharton’s Jelly Stem Cells Through Induction of Apoptosis

The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis

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