IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis

Morrow, Kristen N.; Coopersmith, Craig M.; Ford, Mandy L.

doi:10.3389/fimmu.2019.01982

Cited by 54 publications

(45 citation statements)

References 95 publications

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“…[20][21][22] It has also been demonstrated that IL-33 participates in balancing IL-10 and IL-17 and consequently leads to T helper 2 (Th2) differentiation. 23 In this study, the levels of IL-33 had a significant negative correlation with IL-17 in the active phase of the disease. Also, IL-33 was significantly lower in neopterin-positive patients.…”

Section: Discussionsupporting

confidence: 47%

<p>The IL-33/sST2 Axis in Thromboangiitis Obliterans</p>

Sharebiani

Mohareri

Mirhosseini

et al. 2020

JIR

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Background: Until recently, it remains unknown whether thromboangiitis obliterans (TAO) is a type of systemic vasculitis. A high level of IL-33 and its soluble decoy receptor sST2 in the acute phase of systemic vasculitis has been demonstrated. Methods: The serum level of IL-33 and sST2 in 50 TAO patients, 20 age-and smoking habit-matched controls and 19 age-matched non-smoker controls was evaluated. Results: The mean level of IL-33 in TAO, smokers and non-smokers was 370.2±61.7ng/ mL,132.14±2.6ng/mL and 11.3±0.38ng/mL, respectively. The IL-33 was significantly higher in the TAO than in either control groups (p < 0.001). The IL-33 in the acute phase of TAO was significantly higher than in the patients in the quiescent phase of the disease (p = 0.019). Also, IL-33 in the patients with gangrene was significantly higher than in the patients with non-healing ulcers (p = 0.021). The sST2 in the TAO patients was 49.3±5.58ng/mL, and in smoker and non-smoker controls, it was 45.3±6.3ng/mL and 4.11±0.17ng/mL, respectively. No significant difference was found between the patients and smoker control groups (p = 0.87). The mean ratio of IL-33/sST2 was 27.89±10.44 in the TAO group and, in smokers and non-smokers, it was 2.85±0.48 and 2.84±0.14, respectively. A significantly high level of IL-33/sST2 ratio was observed in TAO patients in both the active and quiescent phases of the disease in comparison to both control groups (p<0.001). Conclusion: The regulation pattern of IL-33/sST2 was different in TAO in comparison to autoimmune vasculitis.

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Section: Discussionsupporting

confidence: 47%

<p>The IL-33/sST2 Axis in Thromboangiitis Obliterans</p>

Sharebiani

Mohareri

Mirhosseini

et al. 2020

JIR

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“…A recent investigation provided interesting data regarding sex differences in IL-33 (112), a cytokine that modulates Th2 responses and decreases the differentiation of T cells into highly proinflammatory Th17 cells (195,196). IL-33 expression is increased in NAWM and lesions of MS patients (197), implying that this cytokine may be part of a compensatory response to detrimental inflammation.…”

Section: Sex Dimorphism Of the Immune System In Msmentioning

confidence: 99%

SeXX Matters in Multiple Sclerosis

2020

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Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative disease of the central nervous system (CNS). An interesting feature that this debilitating disease shares with many other inflammatory disorders is that susceptibility is higher in females than in males, with the risk of MS being three times higher in women compared to men. Nonetheless, while men have a decreased risk of developing MS, many studies suggest that males have a worse clinical outcome. MS exhibits an apparent sexual dimorphism in both the immune response and the pathophysiology of the CNS damage, ultimately affecting disease susceptibility and progression differently. Overall, women are predisposed to higher rates of inflammatory relapses than men, but men are more likely to manifest signs of disease progression and worse CNS damage. The observed sexual dimorphism in MS may be due to sex hormones and sex chromosomes, acting in parallel or combination. In this review, we outline current knowledge on the sexual dimorphism in MS and discuss the interplay of sex chromosomes, sex hormones, and the immune system in driving MS disease susceptibility and progression.

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“…These inflammatory factors include TNF-α, IL-6, IL-10, IL-17, etc. [4]. Immune cells include neutrophils, lymphocytes, etc., especially T lymphocytes, which mediates the cellular immunity of sepsis.…”

Section: Introductionmentioning

confidence: 99%

Influences of Regulation of miR-126 on Inflammation,Th17/Treg Subpopulation Differentiation, and Lymphocyte Apoptosis through Caspase Signaling Pathway in Sepsis

Zou

Yang

et al. 2020

Inflammation

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To observe the inflammatory response, differentiation of Th17/Treg subsets and apoptosis of lymphocytes, by regulating miR-126 in lymphocytes of septic rats. After using cecal ligation and puncture to establish sepsis model, miR-126 mimic and miR-126 inhibitor were used to transfect lymphocytes of septic rats in vitro and in vivo. ELISA was used to detect TNF-α, IL-6, IL-17, and IL-10, the differentiation of Th17 and Treg was measured by flow cytometry, and apoptosis of lymphocytes was observed by fluorescence microscope; the changes of caspase signaling pathway were detected by immunofluorescence, PCR, and Western blotting. The result show that the expression of miR-126 increased in sepsis. After overexpression of miR-126, the release of TNF-α, IL-6, and IL-17 decreased; the release of IL-10 increased; T lymphocyte subsets differentiated toward Treg; caspase signaling pathway weakened; and lymphocyte of apoptosis decreased compared with sepsis group. While, after inhibition of miR-126, the release of TNF-α, IL-6, and IL-17 increased; the release of IL-10 decreased; T lymphocyte subsets differentiated toward TH17; caspase signaling pathway enhanced; and lymphocyte of apoptosis increased compared with sepsis group. Taken together, regulation of miR-126 can alter the inflammatory response, differentiation of T lymphocyte subsets, and apoptosis of lymphocytes in septic rats.

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IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis

Cited by 54 publications

References 95 publications

<p>The IL-33/sST2 Axis in Thromboangiitis Obliterans</p>

<p>The IL-33/sST2 Axis in Thromboangiitis Obliterans</p>

SeXX Matters in Multiple Sclerosis

Influences of Regulation of miR-126 on Inflammation,Th17/Treg Subpopulation Differentiation, and Lymphocyte Apoptosis through Caspase Signaling Pathway in Sepsis

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