2013
DOI: 10.1590/s0074-02762013000100018
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: To verify the response of host cells to trichomonad infection, a primary culture of bovine epithelial cells (BOECs) was grown to model host cells, following previously published procedures (Midlej et al. 2009). The JT strain of T. vaginalis (Fig. 1A) and the K strain of T. foetus (Fig. 1B) were used as models for human and bovine parasites, respectively. Parasites were cultivated in trypticaseyeast extract-maltose (TYM) medium (Diamond 1957) Financial support: CNPq, FAPERJ, CAPES, PRONEX, AUSU + Corresponding … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 13 publications
(4 citation statements)
references
References 17 publications
0
4
0
Order By: Relevance
“…Furthermore, T. vaginalis was also stimulated the secretion of GM-CSF but not IL-6 and IL-1β in pregnant women. [24] However, Han et al [25] reported that TNF-α, IL-1β, and IL-6 were significantly expressed by human macrophages on exposure to T. vaginalis in vitro. The parasite strain may also be concerned in the immunological studies of trichomoniasis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, T. vaginalis was also stimulated the secretion of GM-CSF but not IL-6 and IL-1β in pregnant women. [24] However, Han et al [25] reported that TNF-α, IL-1β, and IL-6 were significantly expressed by human macrophages on exposure to T. vaginalis in vitro. The parasite strain may also be concerned in the immunological studies of trichomoniasis.…”
Section: Discussionmentioning
confidence: 99%
“…IL-10 contributes to inhibition of Th1 immunity and favors a T helper Type 2 response. [18,24] In respect to autoantibodies, the levels of anticardiolipin (IgG and IgM) antibodies and antiphospholipid IgG were significantly elevated in women with trichomoniasis. However, antiphospholipid IgM level was non-significantly elevated in women with trichomoniasis in comparison to uninfected control women.…”
Section: Discussionmentioning
confidence: 99%
“…Molecular expression of pro-inflammatory cytokines, markers for T regulatory and T helper 17 cells, as well as heme oxygenase-1 expression in uterine tissue of BALB/c mice has demonstrated TNF-α augmentation in the uterus of infected animals. Anti-inflammatory cytokine IL-10 was also upregulated (Vilela and Benchimol 2013;Woudwyk et al 2012). These studies provide new hope for development of vaccines against trichomoniasis.…”
Section: Immunization In Humansmentioning
confidence: 77%
“…Nevertheless, some other cells can produce IL-10 (e.g., DCs and epithelial cells) [213,214]. Production of IL-10 results in an anti-inflammatory microenvironment that prevents microbe elimination.…”
Section: A Word Of Caution: Il-10-mediated Immune Evasionmentioning
confidence: 99%