IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma

Fujieda, Shigeharu; Sunaga, Hiroshi; Tsuzuki, Hideaki; Fan, Guo-Kang; Saitô, Hitoshi

doi:10.1016/s0304-3835(98)00281-x

Cited by 43 publications

(49 citation statements)

References 29 publications

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“…The results of this study are consistent with the results of the study conducted by Fujieda et al In their study, the incidence of IL-10 was observed in 82% of oral and pharyngeal SCC tumor tissues and mononuclear cells (Fujieda et al, 1999).…”

Section: Discussionsupporting

confidence: 93%

“…By preventing tumor antigen from reaching antigen-producing cells, IL-10 causes tumors to escape T-cells (Fujieda et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…But the major source of IL-10 production, in studies, is macrophages (Chandler et al, 2002;Asadullah et al, 2003;Sabatet al, 2010). IL-10 is effective on different cell populations, especially circulating and tissueresident immune cells as well as keratinocytes (Fujieda et al, 1999;Sabat et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Tissue Expression, Serum and Salivary Levels of IL-10 in Patients with Head and Neck Squamous Cell Carcinoma

Hamzavi

Andisheh-Tadbir²,

Rezvani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Head and neck SCC is a common cancer related to various factors. IL-10, a pleiotropic cytokine produced by macrophages, T-helper-2 cells, and B lymphocytes, is thought to play a potential pathogenetic or therapeutic role in a number of human conditions, such as inflammation, autoimmunity and cancer. The present study was designed to evaluate the relation between tissue expression, serum and salivary levels of IL-10 in head and neck squamous cell carcinomas (HNSCCs) and their correlation with clinicopathologic features. Materials and Methods: Samples were collected from 30 patients with HNSCCs and 24 healthy volunteers. IHC analysis was used to examine the tissue expression and ELISA was employed to measure serum and salivary levels. Results: Our study showed tissue expression of IL-10 to be significantily higher in patients (P: 0.001), but there was no relation between tissue expression , serum and salivary levels of the marker (P>0.05). Also except for a positive correlation between tissue expression of IL-10 and stage (P: 0.044), there was no relation between this marker and clinicopathologic features. There was no correlation between serum and salivary levels in either patients or controls. Conclusions: It seems there is no correlation between level of IL-10 in serum and saliva and this marker in saliva and serum does not reflect tissue expression.

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Section: Discussionsupporting

confidence: 93%

“…By preventing tumor antigen from reaching antigen-producing cells, IL-10 causes tumors to escape T-cells (Fujieda et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

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Tissue Expression, Serum and Salivary Levels of IL-10 in Patients with Head and Neck Squamous Cell Carcinoma

Hamzavi

Andisheh-Tadbir²,

Rezvani³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…126 In addition, IL-10 has been shown to downregulate immune effector mechanisms, such as CD8 C T-cell mediated tumor cell lysis. 126,127 Furthermore, IL-10 may block T helper 1 cell differentiation and proliferation and suppress production of Th1 cytokines, [128][129][130] which would negatively impact the proliferation of cytotoxic T cells. IL-10 also serves as an activator of STAT, which in turn inhibits maturation of dendritic cells and immature myeloid cells (IMCs) through STAT3 activation.…”

Section: Interleukin-10mentioning

confidence: 99%

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

et al. 2015

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“…Immunoperoxidase staining of formalin-fixed, paraffin-embedded tissue sections was performed using the conventional ABC technique, as previously described (Fujieda et al, 1998). Briefly, paraffin-embedded blocks were cut into 5-µm-thick sections, deparaffinized and rehydrated with an ethanol series.…”

Section: Immuno-histochemical Stainingmentioning

confidence: 99%

Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

et al. 1999

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p27 Kip1 , a cyclin-dependent kinase inhibitor, is a negative regulator of the cell cycle, and apoptosis is a genetically encoded program of cell death. To clarify the relationship between the cell cycle and apoptosis, we investigated expression of p27, cyclin D1 and apoptosis-related proteins (p53, Bax, Bcl-2 and c-Myc) in 60 cases of oral and oropharyngeal squamous-cell carcinoma (SCC) using an immuno-histochemical approach, and evaluated spontaneous apoptosis in vivo. Our most notable finding was that spontaneous apoptosis in the p27-positive group was significantly higher than that in the p27-negative group (p ‫؍‬ 0.028). In addition, the percentage of p27-

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IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma

Cited by 43 publications

References 29 publications

Tissue Expression, Serum and Salivary Levels of IL-10 in Patients with Head and Neck Squamous Cell Carcinoma

Tissue Expression, Serum and Salivary Levels of IL-10 in Patients with Head and Neck Squamous Cell Carcinoma

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

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