Hypospadias is a developmental abnormality in which the male urethra opens on the underside of the penis or on the perineum and can be accompanied by penile aplasia or hypoplasia, hypoplasia of the corpus cavernosum, incomplete formation of the prepuce, or cryptorchidism [1]. In animals, it rarely appears in horses, sheep, goats, cattle, dogs, and cats as isolated cases with urogenital anomaly or with other abnormalities [2,3]. The aim of this paper is to present the hystological results in a crossbred calf seen with anterior hypospadias with syndromic evolution. Clinically, the penile urethra ventrally opened at approximately 4 cm caudal of the normal opening of the urethra, also, the prepuce was incompletely developed and had failed to fuse normally. The Hematoxylin-Eosin method was used for hystological examination of the urethra. Microscopically, the urethra wall was composed of mucosa with epithelium and lamina propria, vascular layer, thin muscle layer, and adventitia, a lax connective tissue. The formation that should be the corpus cavernosum was separated from the body of the corpus spongiosum and urethra. In the center of the structure there was a connective tissue strand made of converging trabeculae. However, between the trabeculae, where the cavernous spaces should be, there was an abundance of monolocular adipocytes. In conclusion, histological examination revealed the normal structure of the urethra with adipose degeneration into the corpus cavernosum.