İki Alman Holştayn Buzağıda Atresia Ani, Hypospadia ve Gelişmemiş Dış Genital Organlar Olgusu

Usta, Zafer

doi:10.17094/ataunivbd.347977

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…In cattle, the frequency of congenital defects is estimated to be 0.25% to 3.6% and can be caused by genetic factors, environmental factors, or genetic-environmental interaction during embryonic development [9,24,25].…”

Section: Introductionmentioning

confidence: 99%

“…Based on the literature data overview of hypospadias in large and small ruminants, it usually appears in single cases alone with urogenital anomalies (penile aplasia or hypoplasia, preputial aplasia or hypoplasia, cryptorchidism) [25,30,36], or with other abnormalities such as atresia ani, atresia recti, omphalophlebities, growth retardation, and ventricular septal defect [30], atresia of the ear and imperforated left ear [37], anorectal abnormalities, cardiovascular abnormalities, cryptorchidism [36], anuria, hermaphrodism, and rudimentary left kidney and left urethral anomaly [29,30].…”

Section: Introductionmentioning

confidence: 99%

“…In the etiology of hypospadias, there are incriminated genetic, endocrinological, environmental factors and even epigenetic alterations of the genetic material [25,28,38]. Data from the literature indicate that between 10-30% of human hypospadias cases can be at-tributed to specific gene mutations (e.g., AR gene mutation, SRD5A type II deficiency), while 70% of cases have unknown etiology, possibly a combination of genes and environmental factors [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Occurrence of Hypospadias and Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic, and Genomic Characterization

Suquet¹,

Mizeranschi

Paul

et al. 2023

Animals

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Congenital abnormalities in animals, including abnormalities of the cleft lip and jaw and hypospadias have been reported in all domesticated species. They are a major concern for breeders due to the increased economic loss they entail. In this article, we described a congenital bilateral cheilognathoschisis (cleft lip and jaw) with campylognathia in association with penile hypospadias and preputial hypoplasia with failure of preputial fusion in a Bos taurus crossbred Piedmontese × Wagyu calf. Clinical examination, computed tomography, and whole genome sequencing were performed to describe and identify a possible cause of the abnormalities. Clinical examination revealed a bilateral cheilognathoschisis of approximately 4 cm in length and 3 cm in width in the widest part, with computer tomography analyses confirming the bilateral absence of the processus nasalis of the incisive bone and the lateral deviation of the processus palatinus towards the left side. Genomic data analyses identified 13 mutations with a high impact on the products of the following overlapped genes: ACVR1, ADGRA2, BHMT2, BMPR1B, CCDC8, CDH1, EGF, F13A1, GSTP1, IRF6, MMP14, MYBPHL, and PHC2 with ADGRA2, EGF, F13A1, GSTP1, and IRF6 having mutations in a homozygous state. The whole genome investigation indicates the involvement of multiple genes in the birth defects observed in this case.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous Occurrence of Hypospadias and Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic, and Genomic Characterization

Suquet¹,

Mizeranschi

Paul

et al. 2023

Animals

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Hystological Investigation of Hypospadias in a Crossbred Calf With Syndromic Evolution

Marc,

Boldura,

Savici

et al. 2023

SGEM International Multidisciplinary Scientific GeoConference� EXPO Proceedings

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Hypospadias is a developmental abnormality in which the male urethra opens on the underside of the penis or on the perineum and can be accompanied by penile aplasia or hypoplasia, hypoplasia of the corpus cavernosum, incomplete formation of the prepuce, or cryptorchidism [1]. In animals, it rarely appears in horses, sheep, goats, cattle, dogs, and cats as isolated cases with urogenital anomaly or with other abnormalities [2,3]. The aim of this paper is to present the hystological results in a crossbred calf seen with anterior hypospadias with syndromic evolution. Clinically, the penile urethra ventrally opened at approximately 4 cm caudal of the normal opening of the urethra, also, the prepuce was incompletely developed and had failed to fuse normally. The Hematoxylin-Eosin method was used for hystological examination of the urethra. Microscopically, the urethra wall was composed of mucosa with epithelium and lamina propria, vascular layer, thin muscle layer, and adventitia, a lax connective tissue. The formation that should be the corpus cavernosum was separated from the body of the corpus spongiosum and urethra. In the center of the structure there was a connective tissue strand made of converging trabeculae. However, between the trabeculae, where the cavernous spaces should be, there was an abundance of monolocular adipocytes. In conclusion, histological examination revealed the normal structure of the urethra with adipose degeneration into the corpus cavernosum.

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İki Alman Holştayn Buzağıda Atresia Ani, Hypospadia ve Gelişmemiş Dış Genital Organlar Olgusu

Cited by 2 publications

References 9 publications

Simultaneous Occurrence of Hypospadias and Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic, and Genomic Characterization

Simultaneous Occurrence of Hypospadias and Bilateral Cleft Lip and Jaw in a Crossbred Calf: Clinical, Computer Tomographic, and Genomic Characterization

Hystological Investigation of Hypospadias in a Crossbred Calf With Syndromic Evolution

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